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However, the existing tools allow one to classify only the simplest knots and cannot be used in automated sample analysis. To answer this need, we created the Topoly Python package. This package enables the distinguishing of knots, slipknots, links and spatial graphs through the calculation of different topological polynomial invariants. It also enables one to create the minimal spanning surface on a given loop, e.g. to detect a lasso motif or to generate random closed polymers. It is capable of reading various file formats, including PDB. The extensive documentation along with test cases and the simplicity of the Python programming language make it a very simple to use yet powerful tool, suitable even for inexperienced users. Topoly can be obtained from https:\/\/topoly.cent.uw.edu.pl.<\/jats:p>","DOI":"10.1093\/bib\/bbaa196","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T19:11:52Z","timestamp":1598382712000},"source":"Crossref","is-referenced-by-count":54,"title":["Topoly: Python package to analyze topology of polymers"],"prefix":"10.1093","volume":"22","author":[{"given":"Pawel","family":"Dabrowski-Tumanski","sequence":"first","affiliation":[]},{"given":"Pawel","family":"Rubach","sequence":"additional","affiliation":[]},{"given":"Wanda","family":"Niemyska","sequence":"additional","affiliation":[]},{"given":"Bartosz Ambrozy","family":"Gren","sequence":"additional","affiliation":[]},{"given":"Joanna 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