{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:54:13Z","timestamp":1773971653833,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Shandong Provincial Key Research and Development Program","award":["2018GSF121001"],"award-info":[{"award-number":["2018GSF121001"]}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2018MH010"],"award-info":[{"award-number":["ZR2018MH010"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2019MH020"],"award-info":[{"award-number":["ZR2019MH020"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Youth Innovation Team of Shandong Province","award":["2019KJK017"],"award-info":[{"award-number":["2019KJK017"]}]},{"name":"Talent Program of Zibo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In view of great difficulties in the pathogenesis analysis of Alzheimer\u2019s disease (AD) presently, profiling the modifiable risk factors is crucial for early detection and intervention of AD. However, the causal associations among them have yet to be identified, and the effective integration and application of these data also remain considerable challenges due to the lack of efficient collection and analysis procedures. To address this issue, we performed comprehensive analyses by two-sample Mendelian randomization (2SMR) and established the AlzRiskMR database (https:\/\/github.com\/SDBMC\/RiskFactors2AD). Four 2SMR analysis methods, including inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode, were used for the complementary calculation to test the reliability of the results. The database currently comprises 1870 sets of data of Genome-Wide Association Studies (GWAS) from the MR-Base and NHGRI-EBI GWAS Catalog database. AlzRiskMR database not only estimates causal associations between modifiable risk factors and AD but also offers a useful and timely resource for early intervention of AD development incidence.<\/jats:p>","DOI":"10.1093\/bib\/bbaa213","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T13:26:25Z","timestamp":1597411585000},"source":"Crossref","is-referenced-by-count":6,"title":["AlzRiskMR database: an online database for the impact of exposure factors on Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"22","author":[{"given":"Zhe","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Meng","sequence":"additional","affiliation":[{"name":"Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shen","sequence":"additional","affiliation":[{"name":"Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-3590","authenticated-orcid":false,"given":"Hong-Fang","family":"Ji","sequence":"additional","affiliation":[{"name":"Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"2021052110413874800_ref1","volume-title":"World Alzheimer Report 2018-The state of the art of dementia research: New frontiers","author":"Alzheimer\u2019s disease International","year":"2018"},{"key":"2021052110413874800_ref2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1445-5994.2012.02758.x","article-title":"Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal 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