{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:47:28Z","timestamp":1771512448436,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560134"],"award-info":[{"award-number":["81560134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660091"],"award-info":[{"award-number":["81660091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of Guangxi","award":["2019GXNSFBA185015"],"award-info":[{"award-number":["2019GXNSFBA185015"]}]},{"name":"National Natural Science Foundation of Guangxi","award":["2018GXNSFAA281242"],"award-info":[{"award-number":["2018GXNSFAA281242"]}]},{"name":"Taiwan Province Talented Young Scientist Program of Guangxi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19). However, anti-CRC\/COVID-19 treatment options are currently unavailable. Since niacin is a vitamin with cytoprotective and anti-inflammatory functions, this study aimed to evaluate the possible functional roles and underlying mechanisms of action of niacin as an anti-COVID-19 and -CRC therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>We used a series of network pharmacology-based and computational analyses to understand and characterize the binding capacity, biological functions, pharmacological targets and therapeutic mechanisms of niacin in CRC\/COVID-19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and main results<\/jats:title><jats:p>We revealed the clinical characteristics of CRC patients and COVID-19 patients, including predisposing genes, survival rate and prognosis. Moreover, the results of molecular docking analysis indicated that niacin exerted effective binding capacity in COVID-19. Further, we disclosed the targets, biological functions and signaling pathways of niacin in CRC\/COVID-19. The analysis indicated that niacin could help in treating CRC\/COVID-19 through cytoprotection, enhancement of immunologic functions, inhibition of inflammatory reactions and regulation of cellular microenvironment. Furthermore, five core pharmacological targets of niacin in CRC\/COVID-19 were also identified, including BCL2L1, PTGS2, IL1B, IFNG and SERPINE1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study, for the first time, revealed the niacin-associated molecular functions and pharmacological targets for treating CRC\/COVID-19, as COVID-19 remains a serious pandemic. But the findings were not validated in actual CRC patients infected with COVID-19, so further investigation is needed to confirm the potential use of niacin for treating CRC\/COVID-19.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bib\/bbaa300","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T19:09:39Z","timestamp":1602184179000},"page":"1279-1290","source":"Crossref","is-referenced-by-count":115,"title":["Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets"],"prefix":"10.1093","volume":"22","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[{"name":"Gyuilin Medical University"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Gyuilin Medical University"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Gyuilin Medical 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