{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:40:47Z","timestamp":1785796847911,"version":"3.56.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["62061034"],"award-info":[{"award-number":["62061034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["61702290"],"award-info":[{"award-number":["61702290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["61861036"],"award-info":[{"award-number":["61861036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region","award":["NJYT-18-B01"],"award-info":[{"award-number":["NJYT-18-B01"]}]},{"name":"Excellent Young Scholars of Inner Mongolia","award":["2017JQ04"],"award-info":[{"award-number":["2017JQ04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Developmental pluripotency-associated 2 (Dppa2) and developmental pluripotency-associated 4 (Dppa4) as positive drivers were helpful for transcriptional regulation of zygotic genome activation (ZGA). Here, we systematically assessed the cooperative interplay of Dppa2 and Dppa4 in regulating cell pluripotency and found that simultaneous overexpression of Dppa2\/4 can make induced pluripotent stem cells closer to embryonic stem cells (ESCs). Compared with other pluripotency transcription factors, Dppa2\/4 can regulate majorities of signaling pathways by binding on CG-rich region of proximal promoter (0\u2013500\u00a0bp), of which 85% and 77% signaling pathways were significantly activated by Dppa2 and Dppa4, respectively. Notably, Dppa2\/4 also can dramatically trigger the decisive signaling pathways for facilitating ZGA, including Hippo, MAPK and TGF-beta signaling pathways and so on. At last, we found alkaline phosphatase, placental-like 2 (Alppl2) was completely silenced when Dppa2 and 4 single- or double-knockout in ESC, which is consistent with Dux. Moreover, Alppl2 was significantly activated in mouse 2-cell embryos and 4\u20138 cells stage of human embryos, further predicted that Alppl2 was directly regulated by Dppa2\/4 as a ZGA candidate driver to facilitate pre-embryonic development.<\/jats:p>","DOI":"10.1093\/bib\/bbaa342","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T12:09:43Z","timestamp":1603886983000},"source":"Crossref","is-referenced-by-count":23,"title":["Dppa2\/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region"],"prefix":"10.1093","volume":"22","author":[{"given":"Hanshuang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunshen","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhu","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-7835","authenticated-orcid":false,"given":"Yongchun","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"2021072117010429000_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41556-019-0453-8","article-title":"Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells","volume":"22","author":"Hu","year":"2020","journal-title":"Nat Cell Biol"},{"key":"2021072117010429000_ref2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.omtn.2019.12.035","article-title":"A comparative analysis of single-cell transcriptome identifies reprogramming driver factors for efficiency improvement","volume":"19","author":"Li","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"2021072117010429000_ref3","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/ng.3858","article-title":"DUX-family transcription factors regulate zygotic genome activation in placental mammals","volume":"49","author":"De Iaco","year":"2017","journal-title":"Nat Genet"},{"key":"2021072117010429000_ref4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/ng.3844","article-title":"Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL\/HERVL retrotransposons","volume":"49","author":"Hendrickson","year":"2017","journal-title":"Nat Genet"},{"key":"2021072117010429000_ref5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ng.3846","article-title":"Conservation and innovation in the DUX4-family gene network","volume":"49","author":"Whiddon","year":"2017","journal-title":"Nat Genet"},{"key":"2021072117010429000_ref6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11244","article-title":"Embryonic stem cell potency fluctuates with endogenous retrovirus activity","volume":"487","author":"Macfarlan","year":"2012","journal-title":"Nature"},{"key":"2021072117010429000_ref7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000324","article-title":"DPPA2\/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program","volume":"17","author":"Yan","year":"2019","journal-title":"PLoS Biol"},{"key":"2021072117010429000_ref8","first-page":"8485","article-title":"Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes","volume":"47","author":"Zhang","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2021072117010429000_ref9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41588-019-0418-7","article-title":"Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development","volume":"51","author":"Chen","year":"2019","journal-title":"Nat Genet"},{"key":"2021072117010429000_ref10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13287-015-0137-7","article-title":"Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity","volume":"6","author":"Kang","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"2021072117010429000_ref11","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1128\/MCB.01970-08","article-title":"The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis","volume":"29","author":"Madan","year":"2009","journal-title":"Mol Cell Biol"},{"key":"2021072117010429000_ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1634\/stemcells.2006-0269","article-title":"Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line","volume":"25","author":"Maldonado-Saldivia","year":"2007","journal-title":"Stem Cells"},{"key":"2021072117010429000_ref13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0968-0004(99)01537-6","article-title":"SAP - a putative DNA-binding motif involved in chromosomal organization","volume":"25","author":"Aravind","year":"2000","journal-title":"Trends Biochem Sci"},{"key":"2021072117010429000_ref14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2443.2010.01382.x","article-title":"DPPA4 modulates chromatin structure via association with DNA and core histone H3 in mouse embryonic stem cells","volume":"15","author":"Masaki","year":"2010","journal-title":"Genes Cells"},{"key":"2021072117010429000_ref15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1101\/gad.321174.118","article-title":"Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program","volume":"33","author":"Eckersley-Maslin","year":"2019","journal-title":"Genes Dev"},{"key":"2021072117010429000_ref16","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201847382","article-title":"DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells","volume":"20","author":"De Iaco","year":"2019","journal-title":"EMBO Rep"},{"key":"2021072117010429000_ref17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41594-020-0445-1","article-title":"Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development","volume":"27","author":"Gretarsson","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"2021072117010429000_ref18","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41594-020-0443-3","article-title":"Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment","volume":"27","author":"Eckersley-Maslin","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"2021072117010429000_ref19","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1038\/ncomms8155","article-title":"Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry","volume":"6","author":"Engelen","year":"2015","journal-title":"Nat Commun"},{"key":"2021072117010429000_ref20","doi-asserted-by":"crossref","first-page":"33034","DOI":"10.1074\/jbc.M703245200","article-title":"Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage","volume":"282","author":"Masaki","year":"2007","journal-title":"J Biol Chem"},{"key":"2021072117010429000_ref21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.stem.2018.08.001","article-title":"Dppa2\/4 facilitate epigenetic remodeling during reprogramming to pluripotency","volume":"23","author":"Hernandez","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2021072117010429000_ref22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jcp.21440","article-title":"Identification of DPPA4 and other genes as putative Sox2 : Oct-3\/4 target genes using a combination of in silico analysis and transcription-based assays","volume":"216","author":"Chakravarthy","year":"2008","journal-title":"J Cell Physiol"},{"key":"2021072117010429000_ref23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.scr.2018.07.009","article-title":"Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer","volume":"31","author":"Klein","year":"2018","journal-title":"Stem Cell Res"},{"key":"2021072117010429000_ref24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13059-018-1461-x","article-title":"CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness","volume":"19","author":"Morgan","year":"2018","journal-title":"Genome Biol"},{"key":"2021072117010429000_ref25","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/bioinformatics\/btr189","article-title":"MEME-ChIP: motif analysis of large DNA datasets","volume":"27","author":"Machanick","year":"2011","journal-title":"Bioinformatics"},{"key":"2021072117010429000_ref26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/dgd.12335","article-title":"Roles and regulations of Hippo signaling during preimplantation mouse development","volume":"59","author":"Sasaki","year":"2016","journal-title":"Dev Growth Differ"},{"key":"2021072117010429000_ref27","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1109\/TIP.2010.2040763","article-title":"A robust fuzzy local information C-means clustering algorithm","volume":"19","author":"Krinidis","year":"2010","journal-title":"IEEE Trans Image Process"},{"key":"2021072117010429000_ref28","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2016.10","article-title":"Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing","volume":"2","author":"Liu","year":"2016","journal-title":"Cell Discov"},{"key":"2021072117010429000_ref29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature12364","article-title":"Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing","volume":"500","author":"Xue","year":"2013","journal-title":"Nature"},{"key":"2021072117010429000_ref30","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.cell.2019.01.006","article-title":"Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming","volume":"176","author":"Schiebinger","year":"2019","journal-title":"Cell"},{"key":"2021072117010429000_ref31","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41556-018-0093-4","article-title":"Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development","volume":"20","author":"Wang","year":"2018","journal-title":"Nat Cell Biol"},{"key":"2021072117010429000_ref32","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1186\/s12864-018-5091-1","article-title":"Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by single-embryo RNA sequencing","volume":"19","author":"Liu","year":"2018","journal-title":"BMC Genomics"},{"key":"2021072117010429000_ref33","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1128\/MCB.05701-11","article-title":"Essential roles of ECAT15-2\/Dppa2 in functional lung development","volume":"31","author":"Nakamura","year":"2011","journal-title":"Mol Cell Biol"},{"key":"2021072117010429000_ref34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nutres.2019.10.008","article-title":"Low folate status, and MTHFR 677C&gt;T and MTR 2756A&gt;G polymorphisms associated with colorectal cancer risk in Thais: a case-control study","volume":"72","author":"Panprathip","year":"2019","journal-title":"Nutr Res"},{"key":"2021072117010429000_ref35","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1002\/jcp.26564","article-title":"Folate deficiency inhibits the PCP pathway and alters genomic methylation levels during embryonic development","volume":"233","author":"Geng","year":"2018","journal-title":"J Cell Physiol"},{"key":"2021072117010429000_ref36","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10072-019-04119-4","article-title":"Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms","volume":"41","author":"Karatoprak","year":"2019","journal-title":"Neurol Sci"},{"key":"2021072117010429000_ref37","first-page":"3488","article-title":"Methylation of the promoter region of the MTRR gene in childhood acute lymphoblastic leukemia","volume":"41","author":"Bai","year":"2019","journal-title":"Oncol Rep"},{"key":"2021072117010429000_ref38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2013.09.002","article-title":"Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development","volume":"155","author":"Padmanabhan","year":"2013","journal-title":"Cell"},{"key":"2021072117010429000_ref39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1753-4887.2000.tb01863.x","article-title":"Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis","volume":"58","author":"Kim","year":"2000","journal-title":"Nutr Rev"},{"key":"2021072117010429000_ref40","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3389\/fendo.2019.00777","article-title":"Growth hormone and insulin-like growth factor action in reproductive tissues","volume":"10","author":"Ipsa","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2021072117010429000_ref41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/BST20110609","article-title":"Cross-talk between mitogenic Ras\/MAPK and survival PI3K\/Akt pathways: a fine balance","volume":"40","author":"Aksamitiene","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"2021072117010429000_ref42","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1016\/j.celrep.2020.02.090","article-title":"Identification of ALPPL2 as a naive pluripotent state-specific surface protein essential for human naive pluripotency regulation","volume":"30","author":"Bi","year":"2020","journal-title":"Cell Rep"},{"key":"2021072117010429000_ref43","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat Protoc"},{"key":"2021072117010429000_ref44","article-title":"Using MACS to identify peaks from ChIP-Seq data","volume":"Chapter 2","author":"Feng","year":"2011","journal-title":"Curr Protoc Bioinformatics"},{"key":"2021072117010429000_ref45","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/Bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"2021072117010429000_ref46","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.celrep.2016.01.013","article-title":"Hierarchical Oct4 binding in concert with primed epigenetic rearrangements during somatic cell reprogramming","volume":"14","author":"Chen","year":"2016","journal-title":"Cell Rep"},{"key":"2021072117010429000_ref47","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"2021072117010429000_ref48","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2021072117010429000_ref49","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2021072117010429000_ref50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"2021072117010429000_ref51","doi-asserted-by":"crossref","volume-title":"Foundational and Applied Statistics for Biologists using R","author":"Aho","DOI":"10.1201\/b16126"},{"key":"2021072117010429000_ref52","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/asi.10242","article-title":"Requirements for a cocitation similarity measure, with special reference to Pearson's correlation coefficient","volume":"54","author":"Ahlgren","year":"2003","journal-title":"J Am Soc Inf Sci Tech"},{"key":"2021072117010429000_ref53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1109\/TCBB.2013.147","article-title":"A survey and comparative study of statistical tests for identifying differential expression from microarray data","volume":"11","author":"Bandyopadhyay","year":"2014","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"2021072117010429000_ref54","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10654-016-0149-3","article-title":"Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations","volume":"31","author":"Greenland","year":"2016","journal-title":"Eur J Epidemiol"},{"key":"2021072117010429000_ref55","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"UpSetR: an R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway","year":"2017","journal-title":"Bioinformatics"},{"key":"2021072117010429000_ref56","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsdottir","year":"2013","journal-title":"Brief Bioinform"},{"key":"2021072117010429000_ref57","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2016.12.016","article-title":"Cooperative binding of transcription factors orchestrates reprogramming","volume":"168","author":"Chronis","year":"2017","journal-title":"Cell"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/22\/4\/bbaa342\/39136339\/bbaa342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/22\/4\/bbaa342\/39136339\/bbaa342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T17:14:40Z","timestamp":1626887680000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbaa342\/6034044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,15]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7,20]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbaa342","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7]]},"published":{"date-parts":[[2020,12,15]]},"article-number":"bbaa342"}}