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Previous studies attribute such bell-shaped distributions to the reduced proliferative potential in senior years but fail to explain why some cancers have their occurrence peak at 30+ or 40+. We present a computational model to offer a new explanation to such distributions. The model uses two factors to explain the observed age-dependent cancer occurrence rates: cancer risk of an organ and the availability level of the growth signals in circulation needed by a cancer type, with the former increasing and the latter decreasing with age. Regression analyses were conducted of known occurrence rates against such factors for triple negative breast cancer, testicular cancer and cervical cancer; and all achieved highly tight fitting results, which were also consistent with clinical, gene-expression and cancer-drug data. These reveal a fundamentally important relationship: while cancer is driven by endogenous stressors, it requires sufficient levels of exogenous growth signals to happen, hence suggesting the realistic possibility for treating cancer via cleaning out the growth signals in circulation needed by a cancer.<\/jats:p>","DOI":"10.1093\/bib\/bbaa349","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T12:08:51Z","timestamp":1604405331000},"source":"Crossref","is-referenced-by-count":4,"title":["Understanding the unimodal distributions of cancer occurrence rates: it takes two factors for a cancer to occur"],"prefix":"10.1093","volume":"22","author":[{"given":"Shuang","family":"Qiu","sequence":"first","affiliation":[{"name":"Cancer Systems Biology Center, China-Japan Union Hospital of Jilin University"}]},{"given":"Zheng","family":"An","sequence":"additional","affiliation":[{"name":"Cancer Systems Biology Center, China-Japan Union Hospital of Jilin University"}]},{"given":"Renbo","family":"Tan","sequence":"additional","affiliation":[{"name":"Cancer Systems Biology Center, China-Japan Union Hospital of Jilin University"}]},{"given":"Ping-an","family":"He","sequence":"additional","affiliation":[{"name":"Zhejiang Sci-Tech University"}]},{"given":"Jingjing","family":"Jing","sequence":"additional","affiliation":[{"name":"China Medical University and Jilin University First Hospital"}]},{"given":"Hongxia","family":"Li","sequence":"additional","affiliation":[{"name":"China Medical University and Jilin University First Hospital"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Changchun Normal University"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"University of Georgia and Jilin University"}]}],"member":"286","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"2021072117045026600_ref1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrc3497","article-title":"How ageing processes influence cancer","volume":"13","author":"Magalhaes","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"2021072117045026600_ref2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.1260825","article-title":"Cancer etiology. 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