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Now, although a few drugs and vaccines have been proved for its treatment and prevention, little systematic comments are made to explain its susceptibility to humans. A few scattered studies used bioinformatics methods to explore the role of microRNA (miRNA) in COVID-19 infection. Combining these timely reports and previous studies about virus and miRNA, we comb through the available clues and seemingly make the perspective reasonable that the COVID-19 cleverly exploits the interplay between the small miRNA and other biomolecules to avoid being effectively recognized and attacked from host immune protection as well to deactivate functional genes that are crucial for immune system. In detail, SARS-CoV-2 can be regarded as a sponge to adsorb host immune-related miRNA, which forces host fall into dysfunction status of immune system. Besides, SARS-CoV-2 encodes its own miRNAs, which can enter host cell and are not perceived by the host\u2019s immune system, subsequently targeting host function genes to cause illnesses. Therefore, this article presents a reasonable viewpoint that the miRNA-based interplays between the host and SARS-CoV-2 may be the primary cause that SARS-CoV-2 accesses and attacks the host cells.<\/jats:p>","DOI":"10.1093\/bib\/bbab062","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T12:21:43Z","timestamp":1614428503000},"page":"1137-1149","source":"Crossref","is-referenced-by-count":128,"title":["The miRNA: a small but powerful RNA for COVID-19"],"prefix":"10.1093","volume":"22","author":[{"given":"Song","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences in Zhejiang University and the First Affiliated Hospital of Zhejiang University School of Medicine, China"}]},{"given":"Kuerbannisha","family":"Amahong","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences in Zhejiang University, China"}]},{"given":"Xiuna","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences in Zhejiang University, China"}]},{"given":"Xichen","family":"Lian","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences in Zhejiang University, China"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences in Zhejiang University, China"}]},{"given":"Huaicheng","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences in Zhejiang University, China"}]},{"given":"Yan","family":"Lou","sequence":"additional","affiliation":[{"name":"Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, the First Affiliated Hospital, Zhejiang University School of Medicine, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0053","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences in Zhejiang University, China"}]},{"given":"Yunqing","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, the First Affiliated Hospital, Zhejiang University School of Medicine, China"}]}],"member":"286","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"2021032314364522500_ref1","volume-title":"Coronavirus Disease (COVID-19) Pandemic","author":"World Health Organization"},{"key":"2021032314364522500_ref2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat 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