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However, the molecular perturbations induced by the SARS-CoV-2 infection remain unknown. In this paper, from the perspective of omnigenic, we analyze the properties of the neighborhood perturbed by SARS-CoV-2 in the human interactome and disclose the peripheral and core regions of virus-host network (VHN). We find that the virus-host proteins (VHPs) form a significantly connected VHN, among which highly perturbed proteins aggregate into an observable core region. The non-core region of VHN forms a large scale but relatively low perturbed periphery. We further validate that the periphery is non-negligible and conducive to identifying comorbidities and detecting drug repurposing candidates for COVID-19. We particularly put forward a flower model for COVID-19, SARS and H1N1 based on their peripheral regions, and the flower model shows more correlations between COVID-19 and other two similar diseases in common functional pathways and candidate drugs. Overall, our periphery-core pattern can not only offer insights into interconnectivity of SARS-CoV-2 VHPs but also facilitate the research on therapeutic drugs.<\/jats:p>","DOI":"10.1093\/bib\/bbab169","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T19:22:00Z","timestamp":1618255320000},"source":"Crossref","is-referenced-by-count":8,"title":["The peripheral and core regions of virus-host network of COVID-19"],"prefix":"10.1093","volume":"22","author":[{"given":"Bingbo","family":"Wang","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology, Xidian University, Xi'an 710071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianan","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Xidian University, Xi'an 710071, 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