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However, the functions of most of circRNAs remain to be unraveled, and it is time-consuming and costly to uncover those relationships between circRNAs and diseases by conventional experimental methods. Thus, identifying candidate circRNAs for human diseases offers new opportunities to understand the functional properties of circRNAs and the pathogenesis of diseases. In this study, we propose a novel network embedding-based adaptive subspace learning method (NSL2CD) for predicting potential circRNA\u2013disease associations and discovering those disease-related circRNA candidates. The proposed method first calculates disease similarities and circRNA similarities by fully utilizing different data sources and learns low-dimensional node representations with network embedding methods. Then, we adopt an adaptive subspace learning model to discover potential associations between circRNAs and diseases. Meanwhile, an integrated weighted graph regularization term is imposed to preserve local geometric structures of data spaces, and L1,2-norm constraint is also incorporated into the model to realize the smoothness and sparsity of projection matrices. The experiment results show that NSL2CD achieves comparable performance under different evaluation metrics, and case studies further confirm its ability to discover potential candidate circRNAs for human diseases.<\/jats:p>","DOI":"10.1093\/bib\/bbab177","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:07:30Z","timestamp":1618445250000},"source":"Crossref","is-referenced-by-count":27,"title":["NSL2CD: identifying potential circRNA\u2013disease associations based on network embedding and subspace learning"],"prefix":"10.1093","volume":"22","author":[{"given":"Qiu","family":"Xiao","sequence":"first","affiliation":[{"name":"Hunan Normal University and Hunan Xiangjiang Artificial Intelligence Academy, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[{"name":"Hunan Normal University, 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