{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:37:53Z","timestamp":1780317473311,"version":"3.54.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007114","name":"Ralph W. and Grace M. 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Existing computational approaches developed for prioritizing noncoding variants produce inconsistent and even conflicting results. To address these challenges, we propose a novel statistical learning framework, which directly integrates the precomputed functional scores from representative scoring methods. It will maximize the usage of integrated methods by automatically learning the relative contribution of each method and produce an ensemble score as the final prediction. The framework consists of two modes. The first \u2018context-free\u2019 mode is trained using curated causal regulatory variants from a wide range of context and is applicable to predict regulatory variants of unknown and diverse context. The second \u2018context-dependent\u2019 mode further improves the prediction when the training and testing variants are from the same context. By evaluating the framework via both simulation and empirical studies, we demonstrate that it outperforms integrated scoring methods and the ensemble score successfully prioritizes experimentally validated regulatory variants in multiple risk loci.<\/jats:p>","DOI":"10.1093\/bib\/bbab189","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T15:24:09Z","timestamp":1619191449000},"source":"Crossref","is-referenced-by-count":8,"title":["WEVar: a novel statistical learning framework for predicting noncoding regulatory variants"],"prefix":"10.1093","volume":"22","author":[{"given":"Ye","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Computational Biology and Bioinformatics, Indiana 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