{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:48:34Z","timestamp":1769456914439,"version":"3.49.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2020B1111100002"],"award-info":[{"award-number":["2020B1111100002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973814"],"award-info":[{"award-number":["81973814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904132"],"award-info":[{"award-number":["81904132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030310129"],"award-info":[{"award-number":["2017A030310129"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010589"],"award-info":[{"award-number":["2020A1515010589"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Medicine National University Student Innovation and Entrepreneurship Training Project","award":["201810572038"],"award-info":[{"award-number":["201810572038"]}]},{"name":"National College Student Innovation and Entrepreneurship Training Project of Guangzhou University of Chinese Medicine","award":["202010572001"],"award-info":[{"award-number":["202010572001"]}]},{"name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","award":["2018XXTD003"],"award-info":[{"award-number":["2018XXTD003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The clinical consequences of SARS-CoV-2 and DENGUE virus co-infection are not promising. However, their treatment options are currently unavailable. Current studies have shown that quercetin is both resistant to COVID-19 and DENGUE; this study aimed to evaluate the possible functional roles and underlying mechanisms of action of quercetin as a potential molecular candidate against COVID-19 and DENGUE co-infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used a series of bioinformatics analyses to understand and characterize the biological functions, pharmacological targets and therapeutic mechanisms of quercetin in COVID-19 and DENGUE co-infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We revealed the clinical characteristics of COVID-19 and DENGUE, including pathological mechanisms, key inflammatory pathways and possible methods of intervention, 60 overlapping targets related to the co-infection and the drug were identified, the protein\u2013protein interaction (PPI) was constructed and TNF\u03b1, CCL-2 and CXCL8 could become potential drug targets. Furthermore, we disclosed the signaling pathways, biological functions and upstream pathway activity of quercetin in COVID-19 and DENGUE. The analysis indicated that quercetin could inhibit cytokines release, alleviate excessive immune responses and eliminate inflammation, through NF-\u03baB, IL-17 and Toll-like receptor signaling pathway.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study is the first to reveal quercetin as a pharmacological drug for COVID-19 and DENGUE co-infection. COVID-19 and DENGUE co-infection remain a potential threat to the world\u2019s public health system. Therefore, we need innovative thinking to provide admissible evidence for quercetin as a potential molecule drug for the treatment of COVID-19 and DENGUE, but the findings have not been verified in actual patients, so further clinical drug trials are needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bib\/bbab199","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T19:44:35Z","timestamp":1620071075000},"source":"Crossref","is-referenced-by-count":25,"title":["Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENV"],"prefix":"10.1093","volume":"22","author":[{"given":"Wenjiang","family":"Zheng","sequence":"first","affiliation":[{"name":"First Clinical Medical School of the Guangzhou University of Chinese Medicine, 12 Airport Road, Guangzhou 510405, PR China"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, 12 Airport Road, Guangzhou 510405, PR China"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, 12 Airport Road, Guangzhou 510405, PR China"}]},{"given":"Shaofeng","family":"Zhan","sequence":"additional","affiliation":[{"name":"First Clinical Medical School of the Guangzhou University of Chinese Medicine, 12 Airport Road, Guangzhou 510405, PR China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4795-3039","authenticated-orcid":false,"given":"Xiaohong","family":"Liu","sequence":"additional","affiliation":[{"name":"First Clinical Medical School of the Guangzhou University of Chinese Medicine, 12 Airport Road, Guangzhou 510405, PR China"}]}],"member":"286","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"2021110814410736100_ref1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review","volume":"324","author":"Wiersinga","year":"2020","journal-title":"JAMA"},{"key":"2021110814410736100_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2020.06.228","article-title":"Targeting hub genes and pathways of innate immune response in COVID-19: a network biology perspective","volume":"163","author":"Prasad","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"2021110814410736100_ref3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41586-020-2639-4","article-title":"Phase I\/II study of COVID-19 RNA vaccine BNT162b1 in 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