{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:20:37Z","timestamp":1777998037255,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cystic Fibrois Trust","award":["PHZJ_395"],"award-info":[{"award-number":["PHZJ_395"]}]},{"name":"Cystic Fibrois Trust","award":["RG 70975"],"award-info":[{"award-number":["RG 70975"]}]},{"name":"Brazilian National Counsil for Scientific and Technological Development"},{"name":"American Leprosy Mission","award":["PHZJ_576 RG92035"],"award-info":[{"award-number":["PHZJ_576 RG92035"]}]},{"name":"Wellcome Trust Investigator Award","award":["PHZJ\/489 RG83114"],"award-info":[{"award-number":["PHZJ\/489 RG83114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations in hallmark genes are believed to be the main drivers of cancer progression. These mutations are reported in the Catalogue of Somatic Mutations in Cancer (COSMIC). Structural appreciation of where these mutations appear, in protein\u2013protein interfaces, active sites or deoxyribonucleic acid (DNA) interfaces, and predicting the impacts of these mutations using a variety of computational tools are crucial for successful drug discovery and development. Currently, there are 723 genes presented in the COSMIC Cancer Gene Census. Due to the complexity of the gene products, structures of only 87 genes have been solved experimentally with structural coverage between 90% and 100%. Here, we present a comprehensive, user-friendly, web interface (https:\/\/cancer-3d.com\/) of 714 modelled cancer-related genes, including homo-oligomers, hetero-oligomers, transmembrane proteins and complexes with DNA, ribonucleic acid, ligands and co-factors. Using SDM and mCSM software, we have predicted the impacts of reported mutations on protein stability, protein\u2013protein interfaces affinity and protein\u2013nucleic acid complexes affinity. Furthermore, we also predicted intrinsically disordered regions using DISOPRED3.<\/jats:p>","DOI":"10.1093\/bib\/bbab220","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T11:07:39Z","timestamp":1623755259000},"source":"Crossref","is-referenced-by-count":16,"title":["COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets"],"prefix":"10.1093","volume":"22","author":[{"given":"Ali F","family":"Alsulami","sequence":"first","affiliation":[{"name":"Department of Biochemistry at the University of Cambridge, Cambridge CB2 1GA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro H M","family":"Torres","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Modelagem e Din\u00e2mica Molecular, Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Moghul","sequence":"additional","affiliation":[{"name":"UCL Cancer Institute, University College London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh Mohammed","family":"Arif","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda K","family":"Chaplin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundeep Chaitanya","family":"Vedithi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom 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