{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:42:42Z","timestamp":1769852562967,"version":"3.49.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centro Neurolesi Bonino-Pulejo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the newly discovered coronavirus, SARS-CoV-2. Increased severity of COVID-19 has been observed in patients with diabetes mellitus (DM). This study aimed to identify common transcriptional signatures, regulators and pathways between COVID-19 and DM. We have integrated human whole-genome transcriptomic datasets from COVID-19 and DM, followed by functional assessment with gene ontology (GO) and pathway analyses. In peripheral blood mononuclear cells (PBMCs), among the upregulated differentially expressed genes (DEGs), 32 were found to be commonly modulated in COVID-19 and type 2 diabetes (T2D), while 10 DEGs were commonly downregulated. As regards type 1 diabetes (T1D), 21 DEGs were commonly upregulated, and 29 DEGs were commonly downregulated in COVID-19 and T1D. Moreover, 35 DEGs were commonly upregulated in SARS-CoV-2 infected pancreas organoids and T2D islets, while 14 were commonly downregulated. Several GO terms were found in common between COVID-19 and DM. Prediction of the putative transcription factors involved in the upregulation of genes in COVID-19 and DM identified RELA to be implicated in both PBMCs and pancreas. Here, for the first time, we have characterized the biological processes and pathways commonly dysregulated in COVID-19 and DM, which could be in the next future used for the design of personalized treatment of COVID-19 patients suffering from DM as comorbidity.<\/jats:p>","DOI":"10.1093\/bib\/bbab262","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T03:15:26Z","timestamp":1625109326000},"source":"Crossref","is-referenced-by-count":28,"title":["Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-8714","authenticated-orcid":false,"given":"Md Rezanur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh"},{"name":"Department of Biochemistry and Biotechnology, Khwaja Yunus Ali University, Enayetpur, Sirajganj, Bangladesh"}]},{"given":"Tania","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh"}]},{"given":"Md","family":"Shahjaman","sequence":"additional","affiliation":[{"name":"Department of Statistics, Begum Rokeya University, Rangpur, Bangladesh"}]},{"given":"Md Rafiqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia"},{"name":"Department of Pharmacy, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore, Bangladesh"}]},{"given":"Salvo Danilo","family":"Lombardo","sequence":"additional","affiliation":[{"name":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, A-1090 Vienna, Austria"}]},{"given":"Placido","family":"Bramanti","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino-Pulejo\u201d, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy"}]},{"given":"Rosella","family":"Ciurleo","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino-Pulejo\u201d, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy"}]},{"given":"Alessia","family":"Bramanti","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino-Pulejo\u201d, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy"}]},{"given":"Andrey","family":"Tchorbanov","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Institute of Microbiology , Bulgarian Academy of Sciences, Sofia, Bulgaria"},{"name":"National Institute of Immunology, Sofia, Bulgaria"}]},{"given":"Francesco","family":"Fisicaro","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania CT, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6694-1992","authenticated-orcid":false,"given":"Paolo","family":"Fagone","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania CT, Italy"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania CT, Italy"}]},{"given":"Manuela","family":"Pennisi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania CT, 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correlations","volume":"37","author":"Konishi","year":"1985","journal-title":"Ann Inst Stat Math"},{"key":"2021110815070332400_ref29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/biostatistics\/kxr054","article-title":"Removing technical variability in RNA-seq data using conditional quantile normalization","volume":"13","author":"Hansen","year":"2012","journal-title":"Biostatistics"},{"key":"2021110815070332400_ref30","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2021110815070332400_ref31","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level 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transcriptomes reveals novel genes, regulators, and pathways in autism spectrum disorder","volume":"10","author":"Rahman","year":"2020","journal-title":"Brain Sci"},{"key":"2021110815070332400_ref39","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.drudis.2018.11.003","article-title":"Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets","volume":"24","author":"G\u00fcnther","year":"2019","journal-title":"Drug Discov Today"},{"key":"2021110815070332400_ref40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.drudis.2015.10.015","article-title":"Emerging therapeutic targets for the treatment of hepatic fibrosis","volume":"21","author":"Fagone","year":"2016","journal-title":"Drug Discov Today"},{"key":"2021110815070332400_ref41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/096120339600500209","article-title":"In vitro type-1 and type-2 cytokine production in systemic lupus erythematosus: lack of relationship with clinical disease activity","volume":"5","author":"Barcellini","year":"1996","journal-title":"Lupus"},{"key":"2021110815070332400_ref42","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/bcp.12958","article-title":"The therapeutic potential of mTOR inhibitors in breast cancer","volume":"82","author":"Steelman","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"2021110815070332400_ref43","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1593\/neo.10856","article-title":"Anticancer effects of the nitric oxide-modified saquinavir derivative saquinavir-NO against multidrug-resistant cancer cells","volume":"12","author":"Rothweiler","year":"2010","journal-title":"Neoplasia"},{"key":"2021110815070332400_ref44","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3892\/mmr.2012.964","article-title":"Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease","volume":"6","author":"Guo","year":"2012","journal-title":"Mol Med Rep"},{"key":"2021110815070332400_ref45","doi-asserted-by":"crossref","first-page":"E715","DOI":"10.1073\/pnas.1111600109","article-title":"Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1","volume":"109","author":"Kanter","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"2021110815070332400_ref46","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2020.07.015","article-title":"Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1\u03b1\/glycolysis dependent axis","volume":"32","author":"Codo","year":"2020","journal-title":"Cell Metab"},{"key":"2021110815070332400_ref47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.imlet.2010.06.009","article-title":"Lymphocyte activation in type 1 diabetes mellitus: the increased significance of Kv1. 3 potassium channels","volume":"133","author":"Toldi","year":"2010","journal-title":"Immunol Lett"},{"key":"2021110815070332400_ref48","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6494795","article-title":"Role of T lymphocytes in type 2 diabetes and diabetes-associated inflammation","volume":"2017","author":"Xia","year":"2017","journal-title":"J Diabetes Res"},{"key":"2021110815070332400_ref49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2021110815070332400_ref50","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131774","article-title":"Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection","volume":"4","author":"Kulcsar","year":"2019","journal-title":"JCI insight"},{"key":"2021110815070332400_ref51","first-page":"1","article-title":"Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2. Signal Transduct","volume":"5","author":"Catanzaro","year":"2020","journal-title":"Target Ther"},{"key":"2021110815070332400_ref52","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fcimb.2019.00270","article-title":"Salmonella pathogenicity island 1 (SPI-1) and its complex regulatory network","volume":"9","author":"Lou","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"2021110815070332400_ref53","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1126\/science.1099962","article-title":"Oscillations in NF-\u03baB signaling control the dynamics of gene expression","volume":"306","author":"Nelson","year":"2004","journal-title":"Science (80-)"},{"key":"2021110815070332400_ref54","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/cen.14288","article-title":"COVID-19 and diabetes: insulin requirements parallel illness severity in critically unwell patients","volume":"93","author":"Wu","year":"2020","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021110815070332400_ref55","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.dsx.2020.08.015","article-title":"Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: a systematic review of literature","volume":"14","author":"Pal","year":"2020","journal-title":"Diabetes Metab Syndr Clin Res Rev"},{"key":"2021110815070332400_ref56","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3892\/ijmm.2014.1917","article-title":"The angiotensin-converting enzyme 2\/angiotensin (1-7)\/mas axis protects the function of pancreatic \u03b2 cells by improving the function of islet microvascular endothelial cells","volume":"34","author":"Lu","year":"2014","journal-title":"Int J Mol Med"},{"key":"2021110815070332400_ref57","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00592-009-0109-4","article-title":"Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes","volume":"47","author":"Yang","year":"2010","journal-title":"Acta Diabetol"},{"key":"2021110815070332400_ref58","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1530\/EC-17-0347","article-title":"On type 1 diabetes mellitus pathogenesis","volume":"7","author":"Paschou","year":"2018","journal-title":"Endocr Connect"},{"key":"2021110815070332400_ref59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/B978-0-12-420196-5.00010-1","article-title":"Chapter 10- Pharmacogenetics and pharmacogenomics","author":"Alfirevic","year":"2016","journal-title":"Med Heal Genomics"},{"key":"2021110815070332400_ref60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jphs.2017.06.004","article-title":"Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner","volume":"134","author":"Tsutsui-Kimura","year":"2017","journal-title":"J Pharmacol Sci"},{"key":"2021110815070332400_ref61","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/DDDT.S162810","article-title":"Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study","volume":"12","author":"Pickering","year":"2018","journal-title":"Drug Des Devel Ther"},{"key":"2021110815070332400_ref62","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1089\/adt.2011.423","article-title":"Domain-based biosensor assay to screen for epidermal growth factor receptor modulators in live cells","volume":"10","author":"Antczak","year":"2012","journal-title":"Assay Drug Dev Technol"},{"key":"2021110815070332400_ref63","doi-asserted-by":"crossref","DOI":"10.1096\/fba.2020-00015","article-title":"The role of growth factor receptors in viral infections: an opportunity for drug repurposing against emerging viral diseases such as COVID-19?","volume":"2","author":"Hondermarck","year":"2020","journal-title":"FASEB 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