{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:13:40Z","timestamp":1768587220999,"version":"3.49.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007156","name":"Hong Kong Innovation and Technology Fund","doi-asserted-by":"crossref","award":["ITF 9440236"],"award-info":[{"award-number":["ITF 9440236"]}],"id":[{"id":"10.13039\/501100007156","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The recent advance of single-cell copy number variation (CNV) analysis plays an essential role in addressing intratumor heterogeneity, identifying tumor subgroups and restoring tumor-evolving trajectories at single-cell scale. Informative visualization of copy number analysis results boosts productive scientific exploration, validation and sharing. Several single-cell analysis figures have the effectiveness of visualizations for understanding single-cell genomics in published articles and software packages. However, they almost lack real-time interaction, and it is hard to reproduce them. Moreover, existing tools are time-consuming and memory-intensive when they reach large-scale single-cell throughputs. We present an online visualization platform, single-cell Somatic Variant Analysis Suite (scSVAS), for real-time interactive single-cell genomics data visualization. scSVAS is specifically designed for large-scale single-cell genomic analysis that provides an arsenal of unique functionalities. After uploading the specified input files, scSVAS deploys the online interactive visualization automatically. Users may conduct scientific discoveries, share interactive visualizations and download high-quality publication-ready figures. scSVAS provides versatile utilities for managing, investigating, sharing and publishing single-cell CNV profiles. We envision this online platform will expedite the biological understanding of cancer clonal evolution in single-cell resolution. All visualizations are publicly hosted at https:\/\/sc.deepomics.org.<\/jats:p>","DOI":"10.1093\/bib\/bbab452","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T21:51:11Z","timestamp":1633470671000},"source":"Crossref","is-referenced-by-count":10,"title":["Somatic variant analysis suite: copy number variation clonal visualization online platform for large-scale single-cell genomics"],"prefix":"10.1093","volume":"23","author":[{"given":"Lingxi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong, China"}]},{"given":"Yuhao","family":"Qing","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong, China"}]},{"given":"Ruikang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong, China"}]},{"given":"Chaohui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong, China"}]},{"given":"Hechen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong, China"},{"name":"School of Computational Science and Engineering, Georgia Institute of Technology, Atlanta GA 30332, USA"}]},{"given":"Xikang","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Software, Northwestern Polytechnical University, Xi\u2019an, 710072, Shaanxi, China"}]},{"given":"Shuai Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong, China"}]}],"member":"286","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"issue":"8","key":"2022011921414034400_ref1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1158\/2159-8290.CD-15-0439","article-title":"Evolutionary determinants of cancer","volume":"5","author":"Greaves","year":"2015","journal-title":"Cancer Discov"},{"issue":"2","key":"2022011921414034400_ref2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbcan.2017.02.001","article-title":"Advances in understanding tumour evolution through single-cell sequencing","volume":"1867","author":"Kuipers","year":"2017","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"1","key":"2022011921414034400_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-1044-8","article-title":"Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line","volume":"3","author":"Velazquez-Villarreal","year":"2020","journal-title":"Commun Biol"},{"issue":"4","key":"2022011921414034400_ref4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nmeth.2883","article-title":"Pyclone: statistical inference of clonal population structure in cancer","volume":"11","author":"Roth","year":"2014","journal-title":"Nat Methods"},{"issue":"8","key":"2022011921414034400_ref5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003665","article-title":"Sciclone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution","volume":"10","author":"Miller","year":"2014","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"2022011921414034400_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-015-0602-8","article-title":"Phylowgs: reconstructing subclonal composition and evolution from whole-genome sequencing of tumors","volume":"16","author":"Deshwar","year":"2015","journal-title":"Genome Biol"},{"issue":"7341","key":"2022011921414034400_ref7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature09807","article-title":"Tumour evolution inferred by single-cell sequencing","volume":"472","author":"Navin","year":"2011","journal-title":"Nature"},{"issue":"5","key":"2022011921414034400_ref8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1101\/gr.188060.114","article-title":"Optimizing sparse sequencing of single cells for highly multiplex copy number profiling","volume":"25","author":"Baslan","year":"2015","journal-title":"Genome Res"},{"issue":"2","key":"2022011921414034400_ref9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nprot.2016.005","article-title":"Highly multiplexed targeted DNA sequencing from single nuclei","volume":"11","author":"Leung","year":"2016","journal-title":"Nat Protoc"},{"issue":"2","key":"2022011921414034400_ref10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nmeth.4140","article-title":"Scalable whole-genome single-cell library preparation without preamplification","volume":"14","author":"Zahn","year":"2017","journal-title":"Nat Methods"},{"issue":"5","key":"2022011921414034400_ref11","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cell.2019.10.026","article-title":"Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing","volume":"179","author":"Laks","year":"2019","journal-title":"Cell"},{"issue":"4","key":"2022011921414034400_ref12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ccell.2020.03.008","article-title":"Advancing cancer research and medicine with single-cell genomics","volume":"37","author":"Lim","year":"2020","journal-title":"Cancer Cell"},{"issue":"7","key":"2022011921414034400_ref13","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nbt.3880","article-title":"Single-cell genome sequencing at ultra-high-throughput with microfluidic droplet barcoding","volume":"35","author":"Lan","year":"2017","journal-title":"Nat Biotechnol"},{"issue":"2","key":"2022011921414034400_ref14","article-title":"Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution","volume":"2","author":"Andor","year":"2020","journal-title":"NAR Genom Bioinform"},{"issue":"3","key":"2022011921414034400_ref15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nmeth.4154","article-title":"Sequencing thousands of single-cell genomes with combinatorial indexing","volume":"14","author":"Vitak","year":"2017","journal-title":"Nat Methods"},{"issue":"4","key":"2022011921414034400_ref16","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.molcel.2019.08.002","article-title":"High-throughput single-cell sequencing with linear amplification","volume":"76","author":"Yin","year":"2019","journal-title":"Mol Cell"},{"issue":"7853","key":"2022011921414034400_ref17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41586-021-03357-x","article-title":"Breast tumours maintain a reservoir of subclonal diversity during expansion","volume":"592","author":"Minussi","year":"2021","journal-title":"Nature"},{"issue":"1","key":"2022011921414034400_ref18","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1186\/2047-217X-1-12","article-title":"Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer","volume":"1","author":"Li","year":"2012","journal-title":"GigaScience"},{"issue":"7513","key":"2022011921414034400_ref19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nature13600","article-title":"Clonal evolution in breast cancer revealed by single nucleus genome sequencing","volume":"512","author":"Wang","year":"2014","journal-title":"Nature"},{"issue":"10","key":"2022011921414034400_ref20","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/ng.3641","article-title":"Punctuated copy number evolution and clonal stasis in triple-negative breast cancer","volume":"48","author":"Gao","year":"2016","journal-title":"Nat Genet"},{"issue":"3","key":"2022011921414034400_ref21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nm.4279","article-title":"Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples","volume":"23","author":"Martelotto","year":"2017","journal-title":"Nat Med"},{"issue":"1\u20132","key":"2022011921414034400_ref22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cell.2017.12.007","article-title":"Multiclonal invasion in breast tumors identified by topographic single cell sequencing","volume":"172","author":"Casasent","year":"2018","journal-title":"Cell"},{"issue":"4","key":"2022011921414034400_ref23","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cell.2018.03.041","article-title":"Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing","volume":"173","author":"Kim","year":"2018","journal-title":"Cell"},{"key":"2022011921414034400_ref24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51480","article-title":"Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing","volume":"9","author":"Baslan","year":"2020","journal-title":"Elife"},{"issue":"6","key":"2022011921414034400_ref25","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/cr.2014.43","article-title":"Discovery of biclonal origin and a novel oncogene slc12a5 in colon cancer by single-cell sequencing","volume":"24","author":"Yu","year":"2014","journal-title":"Cell Res"},{"issue":"8","key":"2022011921414034400_ref26","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1101\/gr.209973.116","article-title":"Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer","volume":"27","author":"Leung","year":"2017","journal-title":"Genome Res"},{"issue":"50","key":"2022011921414034400_ref27","doi-asserted-by":"crossref","first-page":"17947","DOI":"10.1073\/pnas.1420822111","article-title":"Dissecting the clonal origins of childhood acute lymphoblastic leukemia by single-cell genomics","volume":"111","author":"Gawad","year":"2014","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"2022011921414034400_ref28","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1101\/gr.217331.116","article-title":"Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia","volume":"27","author":"Wang","year":"2017","journal-title":"Genome Res"},{"key":"2022011921414034400_ref29","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2018-5348","article-title":"Single-cell analysis of mutational heterogeneity in acute myeloid leukemia tumors with high-throughput droplet microfluidics","volume-title":"Cancer Res","author":"Eastburn","year":"2018"},{"issue":"8","key":"2022011921414034400_ref30","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1158\/2159-8290.CD-18-1453","article-title":"Clonal selection with ras pathway activation mediates secondary clinical resistance to selective flt3 inhibition in acute myeloid leukemia","volume":"9","author":"McMahon","year":"2019","journal-title":"Cancer Discov"},{"issue":"1","key":"2022011921414034400_ref31","first-page":"1","article-title":"Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics","volume":"11","author":"Morita","year":"2020","journal-title":"Nat Commun"},{"issue":"7834","key":"2022011921414034400_ref32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41586-020-2864-x","article-title":"Single-cell mutation analysis of clonal evolution in myeloid malignancies","volume":"587","author":"Miles","year":"2020","journal-title":"Nature"},{"issue":"5","key":"2022011921414034400_ref33","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1158\/1078-0432.CCR-16-1069","article-title":"Genomic amplification of cd274 (pd-l1) in small-cell lung cancer","volume":"23","author":"George","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"11","key":"2022011921414034400_ref34","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nmeth.3578","article-title":"Interactive analysis and assessment of single-cell copy-number variations","volume":"12","author":"Garvin","year":"2015","journal-title":"Nat Methods"},{"issue":"6","key":"2022011921414034400_ref35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nmeth.4303","article-title":"E-scape: interactive visualization of single-cell phylogenetics and cancer evolution","volume":"14","author":"Smith","year":"2017","journal-title":"Nat Methods"},{"issue":"W1","key":"2022011921414034400_ref36","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaa371","article-title":"Oviz-Bio: a web-based platform for interactive cancer genomics data visualization","volume":"48","author":"Jia","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"7382","key":"2022011921414034400_ref37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature10738","article-title":"Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"issue":"7","key":"2022011921414034400_ref38","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ng.3573","article-title":"Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer","volume":"48","author":"McPherson","year":"2016","journal-title":"Nat Genet"},{"issue":"7547","key":"2022011921414034400_ref39","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature14347","article-title":"The evolutionary history of lethal metastatic prostate cancer","volume":"520","author":"Gundem","year":"2015","journal-title":"Nature"},{"issue":"D1","key":"2022011921414034400_ref40","doi-asserted-by":"crossref","first-page":"D745","DOI":"10.1093\/nar\/gky1113","article-title":"Ensembl 2019","volume":"47","author":"Cunningham","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"2022011921414034400_ref41","doi-asserted-by":"crossref","first-page":"D853","DOI":"10.1093\/nar\/gky1095","article-title":"The UCSC genome browser database: 2019 update","volume":"47","author":"Haeussler","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2022011921414034400_ref42","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baq020","article-title":"Genecards version 3: the human gene integrator","volume":"2010","author":"Safran","year":"2010","journal-title":"Database"},{"issue":"6","key":"2022011921414034400_ref43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"issue":"5","key":"2022011921414034400_ref44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cels.2020.03.005","article-title":"Scope: A normalization and copy-number estimation method for single-cell DNA sequencing","volume":"10","author":"Wang","year":"2020","journal-title":"Cell Syst"},{"issue":"2","key":"2022011921414034400_ref45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ng.3468","article-title":"Co-occurrence of myc amplification and tp53 mutations in human cancer","volume":"48","author":"Ulz","year":"2016","journal-title":"Nat Genet"},{"issue":"378","key":"2022011921414034400_ref46","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai8312","article-title":"Loss of tumor suppressor kdm6a amplifies prc2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of ezh2","volume":"9","author":"Ler","year":"2017","journal-title":"Sci Transl Med"},{"issue":"18","key":"2022011921414034400_ref47","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1158\/0008-5472.CAN-14-3702","article-title":"Kat6b is a tumor suppressor histone h3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer","volume":"75","author":"Sim\u00f3-Riudalbas","year":"2015","journal-title":"Cancer Res"},{"issue":"12","key":"2022011921414034400_ref48","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/s41587-019-0336-3","article-title":"Visualizing structure and transitions in high-dimensional biological data","volume":"37","author":"Moon","year":"2019","journal-title":"Nat Biotechnol"},{"key":"2022011921414034400_ref49","doi-asserted-by":"crossref","DOI":"10.2172\/6930282","volume-title":"Looking at Large Data Sets Using Binned Data Plots","author":"Carr","year":"1990"},{"issue":"7","key":"2022011921414034400_ref50","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/bioinformatics\/btz907","article-title":"schex avoids overplotting for large single-cell RNA-sequencing datasets","volume":"36","author":"Freytag","year":"2020","journal-title":"Bioinformatics"},{"issue":"6","key":"2022011921414034400_ref51","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/bib\/bbq090","article-title":"Principal component analysis based methods in bioinformatics studies","volume":"12","author":"Ma","year":"2011","journal-title":"Brief Bioinform"},{"issue":"4\u20135","key":"2022011921414034400_ref52","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0893-6080(00)00026-5","article-title":"Independent component analysis: algorithms and applications","volume":"13","author":"Hyv\u00e4rinen","year":"2000","journal-title":"Neural Netw"},{"key":"2022011921414034400_ref53","first-page":"556","volume-title":"Advances in Neural Information Processing Systems 13 (NIPS)","author":"Lee","year":"2001"},{"issue":"1","key":"2022011921414034400_ref54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"11","key":"2022011921414034400_ref55","article-title":"Visualizing data using t-SNE","volume":"9","author":"Van der Maaten","year":"2008","journal-title":"J Mach Learn Res"},{"issue":"23","key":"2022011921414034400_ref56","first-page":"1","article-title":"Deepmf: deciphering the latent patterns in omics profiles with a deep learning method","volume":"20","author":"Chen","year":"2019","journal-title":"BMC Bioinform"},{"issue":"1","key":"2022011921414034400_ref57","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1186\/s12864-016-3195-z","article-title":"Visualizing tumor evolution with the fishplot package for r","volume":"17","author":"Miller","year":"2016","journal-title":"BMC Genomics"},{"issue":"12","key":"2022011921414034400_ref58","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1093\/annonc\/mdx517","article-title":"Clonevol: clonal ordering and visualization in cancer sequencing","volume":"28","author":"Dang","year":"2017","journal-title":"Ann Oncol"},{"issue":"1","key":"2022011921414034400_ref59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nm.4239","article-title":"Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer","volume":"23","author":"Carter","year":"2017","journal-title":"Nat Med"},{"issue":"4","key":"2022011921414034400_ref60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2011-12-4-r41","article-title":"Gistic2. 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers","volume":"12","author":"Mermel","year":"2011","journal-title":"Genome Biol"},{"issue":"1","key":"2022011921414034400_ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-14256-1","article-title":"Single-cell analysis reveals new evolutionary complexity in uveal melanoma","volume":"11","author":"Durante","year":"2020","journal-title":"Nat Commun"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/23\/1\/bbab452\/42231360\/bbab452.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/23\/1\/bbab452\/42231360\/bbab452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T21:43:57Z","timestamp":1642628637000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbab452\/6406714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,17]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbab452","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1]]},"published":{"date-parts":[[2021,10,20]]},"article-number":"bbab452"}}