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The mechanisms behind the pathogenesis of SARS-CoV-2 are both unique and complex. Omics-scale studies are emerging rapidly and offer a tremendous potential to unravel the puzzle of SARS-CoV-2 pathobiology, as well as moving forward with diagnostics, potential drug targets, risk stratification, therapeutic responses, vaccine development and therapeutic innovation. This review summarizes various aspects of understanding multiomics integration-based molecular characterizations of COVID-19, which to date include the integration of transcriptomics, proteomics, genomics, lipidomics, immunomics and metabolomics to explore virus targets and developing suitable therapeutic solutions through systems biology tools. Furthermore, this review also covers an abridgment of omics investigations related to disease pathogenesis and virulence, the role of host genetic variation and a broad array of immune and inflammatory phenotypes contributing to understanding COVID-19 traits. Insights into this review, which combines existing strategies and multiomics integration profiling, may help further advance our knowledge of COVID-19.<\/jats:p>","DOI":"10.1093\/bib\/bbab485","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T11:07:46Z","timestamp":1635160066000},"source":"Crossref","is-referenced-by-count":36,"title":["Multiomics integration-based molecular characterizations of COVID-19"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-5010","authenticated-orcid":false,"given":"Chuan-Xing","family":"Li","sequence":"first","affiliation":[{"name":"Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7732-456X","authenticated-orcid":false,"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Heart and Lung Centre, Department of Pulmonary Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"The First School of Clinical Medicine, Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University, Lanzhou, China"},{"name":"The First School of Clinical Medicine, Lanzhou University, Lanzhou, China"},{"name":"Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"},{"name":"Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa M","family":"Wheelock","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"2022012000303520900_ref1","doi-asserted-by":"crossref","first-page":"e105896","DOI":"10.15252\/embj.2020105896","article-title":"Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage","volume":"39","author":"Chen","year":"2020","journal-title":"EMBO J"},{"key":"2022012000303520900_ref2","author":"NIH"},{"key":"2022012000303520900_ref3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cmi.2020.03.026","article-title":"COVID-19, SARS and MERS: are they closely related?","volume":"26","author":"Petrosillo","year":"2020","journal-title":"Clin Microbiol 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