{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:17:30Z","timestamp":1778523450928,"version":"3.51.4"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61973174"],"award-info":[{"award-number":["61973174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In biomedical networks, molecular associations are important to understand biological processes and functions. Many computational methods, such as link prediction methods based on graph neural networks (GNNs), have been successfully applied in discovering molecular relationships with biological significance. However, it remains a challenge to explore a method that relies on representation learning of links for accurately predicting molecular associations. In this paper, we present a novel GNN based on link representation (LR-GNN) to identify potential molecular associations. LR-GNN applies a graph convolutional network (GCN)-encoder to obtain node embedding. To represent associations between molecules, we design a propagation rule that captures the node embedding of each GCN-encoder layer to construct the LR. Furthermore, the LRs of all layers are fused in output by a designed layer-wise fusing rule, which enables LR-GNN to output more accurate results. Experiments on four biomedical network data, including lncRNA-disease association, miRNA-disease association, protein\u2013protein interaction and drug\u2013drug interaction, show that LR-GNN outperforms state-of-the-art methods and achieves robust performance. Case studies are also presented on two datasets to verify the ability to predict unknown associations. Finally, we validate the effectiveness of the LR by visualization.<\/jats:p>","DOI":"10.1093\/bib\/bbab513","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T12:18:39Z","timestamp":1636546719000},"source":"Crossref","is-referenced-by-count":65,"title":["LR-GNN: a graph neural network based on link representation for predicting molecular associations"],"prefix":"10.1093","volume":"23","author":[{"given":"Chuanze","family":"Kang","sequence":"first","affiliation":[{"name":"College of Artificial Intelligence, Nankai University, Tongyan Road, 300350, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Artificial Intelligence, Nankai University, Tongyan Road, 300350, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Artificial 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