{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:54:02Z","timestamp":1760954042066,"version":"3.41.2"},"reference-count":195,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62032007","61822108"],"award-info":[{"award-number":["62032007","61822108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Messenger RNA (mRNA) vaccines have shown great potential for anti-tumor therapy due to the advantages in safety, efficacy and industrial production. However, it remains a challenge to identify suitable cancer neoantigens that can be targeted for mRNA vaccines. Abnormal alternative splicing occurs in a variety of tumors, which may result in the translation of abnormal transcripts into tumor-specific proteins. High-throughput technologies make it possible for systematic characterization of alternative splicing as a source of suitable target neoantigens for mRNA vaccine development. Here, we summarized difficulties and challenges for identifying alternative splicing-derived cancer neoantigens from RNA-seq data and proposed a conceptual framework for designing personalized mRNA vaccines based on alternative splicing-derived cancer neoantigens. In addition, several points were presented to spark further discussion toward improving the identification of alternative splicing-derived cancer neoantigens.<\/jats:p>","DOI":"10.1093\/bib\/bbab553","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T12:08:01Z","timestamp":1639656481000},"source":"Crossref","is-referenced-by-count":23,"title":["Identification of alternative splicing-derived cancer neoantigens for mRNA vaccine development"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-3514","authenticated-orcid":false,"given":"Rui","family":"Cheng","sequence":"first","affiliation":[{"name":"Harbin Institute of Technology, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-5529","authenticated-orcid":false,"given":"Zhaochun","family":"Xu","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology, China"}]},{"given":"Meng","family":"Luo","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-8005","authenticated-orcid":false,"given":"Pingping","family":"Wang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology, China"}]},{"given":"Huimin","family":"Cao","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-6451","authenticated-orcid":false,"given":"Xiyun","family":"Jin","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3676-0584","authenticated-orcid":false,"given":"Wenyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-0086","authenticated-orcid":false,"given":"Lixing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology, China"}]},{"given":"Qinghua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology, China"}]}],"member":"286","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"2022031506413277300_ref1","doi-asserted-by":"crossref","first-page":"109821","DOI":"10.1016\/j.biopha.2020.109821","article-title":"Cancer immunotherapy: pros, cons and beyond","volume":"124","author":"Tan","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"7781","key":"2022031506413277300_ref2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/d41586-019-02840-w","article-title":"The advent and rise of monoclonal antibodies","volume":"575","author":"Rajewsky","year":"2019","journal-title":"Nature"},{"issue":"2","key":"2022031506413277300_ref3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMra1703481","article-title":"Immune-related adverse events associated with immune checkpoint 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