{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:31:51Z","timestamp":1779172311644,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61532008"],"award-info":[{"award-number":["61532008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61872157"],"award-info":[{"award-number":["61872157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61932008"],"award-info":[{"award-number":["61932008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018583","name":"Wuhan Science and Technology Program","doi-asserted-by":"publisher","award":["2019010701011392"],"award-info":[{"award-number":["2019010701011392"]}],"id":[{"id":"10.13039\/501100018583","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Hubei Province","award":["2020BAB017"],"award-info":[{"award-number":["2020BAB017"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["CCNU19TD004"],"award-info":[{"award-number":["CCNU19TD004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Fund of Guangxi Key Lab of Multi-source Information Mining & Security","award":["MIMS19-02"],"award-info":[{"award-number":["MIMS19-02"]}]},{"name":"Guangxi Key Laboratory of Trusted Software","award":["kx201905"],"award-info":[{"award-number":["kx201905"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The increasing prevalence of antibiotic resistance has become a global health crisis. For the purpose of safety regulation, it is of high importance to identify antibiotic resistance genes (ARGs) in bacteria. Although culture-based methods can identify ARGs relatively more accurately, the identifying process is time-consuming and specialized knowledge is required. With the rapid development of whole genome sequencing technology, researchers attempt to identify ARGs by computing sequence similarity from public databases. However, these computational methods might fail to detect ARGs due to the low sequence identity to known ARGs. Moreover, existing methods cannot effectively address the issue of multidrug resistance prediction for ARGs, which is a great challenge to clinical treatments. To address the challenges, we propose an end-to-end multi-label learning framework for predicting ARGs. More specifically, the task of ARGs prediction is modeled as a problem of multi-label learning, and a deep neural network-based end-to-end framework is proposed, in which a specific loss function is introduced to employ the advantage of multi-label learning for ARGs prediction. In addition, a dual-view modeling mechanism is employed to make full use of the semantic associations among two views of ARGs, i.e. sequence-based information and structure-based information. Extensive experiments are conducted on publicly available data, and experimental results demonstrate the effectiveness of the proposed framework on the task of ARGs prediction.<\/jats:p>","DOI":"10.1093\/bib\/bbac052","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T12:10:02Z","timestamp":1643803802000},"source":"Crossref","is-referenced-by-count":5,"title":["A multi-label learning framework for predicting antibiotic resistance genes via dual-view modeling"],"prefix":"10.1093","volume":"23","author":[{"given":"Weizhong","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Computer, Central China Normal University, Wuhan, Hubei, 430079, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujie","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Computer, Central China Normal University, Wuhan, Hubei, 430079, PR 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