{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T21:44:15Z","timestamp":1772487855700,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Metals are present in &amp;gt;30% of proteins found in nature and assist them to perform important biological functions, including storage, transport, signal transduction and enzymatic activity. Traditional and experimental techniques for metal-binding site prediction are usually costly and time-consuming, making computational tools that can assist in these predictions of significant importance. Here we present Genetic Active Site Search (GASS)-Metal, a new method for protein metal-binding site prediction. The method relies on a parallel genetic algorithm to find candidate metal-binding sites that are structurally similar to curated templates from M-CSA and MetalPDB. GASS-Metal was thoroughly validated using homologous proteins and conservative mutations of residues, showing a robust performance. The ability of GASS-Metal to identify metal-binding sites was also compared with state-of-the-art methods, outperforming similar methods and achieving an MCC of up to 0.57 and detecting up to 96.1% of the sites correctly. GASS-Metal is freely available at https:\/\/gassmetal.unifei.edu.br. The GASS-Metal source code is available at https:\/\/github.com\/sandroizidoro\/gassmetal-local.<\/jats:p>","DOI":"10.1093\/bib\/bbac178","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T19:10:04Z","timestamp":1650913804000},"source":"Crossref","is-referenced-by-count":14,"title":["GASS-Metal: identifying metal-binding sites on protein structures using genetic algorithms"],"prefix":"10.1093","volume":"23","author":[{"given":"Vin\u00edcius A","family":"Paiva","sequence":"first","affiliation":[{"name":"Department of Computer Science , , Vi\u00e7osa , Brazil"},{"name":"Universidade Federal de Vi\u00e7osa , , Vi\u00e7osa , Brazil"}]},{"given":"Murillo V","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences , , Itabira , Brazil"},{"name":"Campus Theodomiro Carneiro Santiago, Universidade Federal de Itajub\u00e1 , , Itabira , Brazil"}]},{"given":"Sabrina A","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Computer Science , , Vi\u00e7osa , Brazil"},{"name":"Universidade Federal de Vi\u00e7osa , , Vi\u00e7osa , Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-2413","authenticated-orcid":false,"given":"David B","family":"Ascher","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences , , St Lucia, Queensland , Australia"},{"name":"University of Queensland , , St Lucia, Queensland , Australia"},{"name":"Systems and Computational Biology, Bio21 Institute, University of Melbourne , Melbourne, Victoria , Australia"},{"name":"Computational Biology and Clinical Informatics , , Melbourne, Victoria , Australia"},{"name":"Baker Heart and Diabetes Institute , , Melbourne, Victoria , Australia"},{"name":"Baker Department of Cardiometabolic Health , , Melbourne, Victoria , Australia"},{"name":"University of Melbourne , , Melbourne, Victoria , Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-2119","authenticated-orcid":false,"given":"Douglas E V","family":"Pires","sequence":"additional","affiliation":[{"name":"Systems and Computational Biology, Bio21 Institute, University of Melbourne , Melbourne, Victoria , Australia"},{"name":"Computational Biology and Clinical Informatics , , Melbourne, Victoria , Australia"},{"name":"Baker Heart and Diabetes Institute , , Melbourne, Victoria , Australia"},{"name":"School of Computing and Information Systems , , Melbourne, Victoria , Australia"},{"name":"University of Melbourne , , Melbourne, Victoria , Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-3321","authenticated-orcid":false,"given":"Sandro C","family":"Izidoro","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences , , Itabira , Brazil"},{"name":"Campus Theodomiro Carneiro Santiago, Universidade Federal de Itajub\u00e1 , , Itabira , 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