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Nevertheless, functional characterization of the altered RNA editing sites still remains a challenge. Here, we developed perturbations of RNA editing sites (PRES; http:\/\/bio-bigdata.hrbmu.edu.cn\/PRES\/) as the webserver for decoding functional perturbations of RNA editing sites based on editome profiling. After uploading an editome profile among samples of different groups, PRES will first annotate the editing sites to various genomic elements and detect differential editing sites under the user-selected method and thresholds. Next, the downstream functional perturbations of differential editing sites will be characterized from gain or loss miRNA\/RNA binding protein regulation, RNA and protein structure changes, and the perturbed biological pathways. A prioritization module was developed to rank genes based on their functional consequences of RNA editing events. PRES provides user-friendly functionalities, ultra-efficient calculation, intuitive table and figure visualization interface to display the annotated RNA editing events, filtering options and elaborate application notebooks. We anticipate PRES will provide an opportunity for better understanding the regulatory mechanisms of RNA editing in human complex diseases.<\/jats:p>","DOI":"10.1093\/bib\/bbac242","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:50:37Z","timestamp":1655711437000},"source":"Crossref","is-referenced-by-count":2,"title":["PRES: a webserver for decoding the functional perturbations of RNA editing sites"],"prefix":"10.1093","volume":"23","author":[{"given":"Dezhong","family":"Lv","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"given":"Kang","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"given":"Changbo","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"given":"Ya","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"given":"Weiwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"given":"Haozhe","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"},{"name":"Hainan Women and Children\u2019s Medical Center, Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Biomedical Information and Engineering, Hainan Medical University , Haikou, Hainan 571199 , China"}]},{"given":"Yangyang","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"given":"Na","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-2648","authenticated-orcid":false,"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"},{"name":"Hainan Women and Children\u2019s Medical Center, Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Biomedical Information and Engineering, Hainan Medical University , Haikou, Hainan 571199 , China"}]},{"given":"Tingting","family":"Shao","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-0727","authenticated-orcid":false,"given":"Yongsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Hainan Women and Children\u2019s Medical Center, Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Biomedical Information and Engineering, Hainan Medical University , Haikou, Hainan 571199 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3709-4165","authenticated-orcid":false,"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University , Harbin, Heilongjiang 150081 , 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