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However, the identified signature is reported to be highly inconsistent, and there is little overlap among the signatures identified from different biological datasets. Such inconsistency raises doubts about the reliability of reported signatures and significantly hampers its biological and clinical applications. Herein, an online tool, ConSIG, was constructed to realize consistent discovery of gene\/protein signature from any uploaded transcriptomic\/proteomic data. This tool is unique in a) integrating a novel strategy capable of significantly enhancing the consistency of signature discovery, b) determining the optimal signature by collective assessment, and c) confirming the biological relevance by enriching the disease\/gene ontology. With the increasingly accumulated concerns about signature consistency and biological relevance, this online tool is expected to be used as an essential complement to other existing tools for OMIC-based signature discovery. ConSIG is freely accessible to all users without login requirement at https:\/\/idrblab.org\/consig\/<\/jats:p>","DOI":"10.1093\/bib\/bbac253","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T10:37:23Z","timestamp":1656326243000},"source":"Crossref","is-referenced-by-count":60,"title":["ConSIG: consistent discovery of molecular signature from OMIC data"],"prefix":"10.1093","volume":"23","author":[{"given":"Fengcheng","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"},{"name":"Zhejiang University School of Medicine , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"}]},{"given":"Jiayi","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"},{"name":"Zhejiang University School of Medicine , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"}]},{"given":"Mingkun","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"},{"name":"Zhejiang University School of Medicine , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"}]},{"given":"Qingxia","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"},{"name":"Zhejiang University School of Medicine , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"}]},{"given":"Zhenyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University , Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110 , China"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University , Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110 , China"}]},{"given":"Zhaorong","family":"Li","sequence":"additional","affiliation":[{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University , Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110 , China"}]},{"given":"Yunqing","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, , 79 QingChun Road, Hangzhou, Zhejiang 310000 , China"},{"name":"Zhejiang University , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, , 79 QingChun Road, Hangzhou, Zhejiang 310000 , China"}]},{"given":"Haibin","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"},{"name":"Zhejiang University School of Medicine , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"}]},{"given":"Yuzong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics , Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, , Shenzhen 518055 , China"},{"name":"Tsinghua University , Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, , Shenzhen 518055 , China"},{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences , Institute of Drug Discovery Technology, , Ningbo 315211 , China"},{"name":"Ningbo University , Institute of Drug Discovery Technology, , Ningbo 315211 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0053","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"},{"name":"Zhejiang University School of Medicine , The Second Affiliated Hospital, , Zhejiang University, Hangzhou 310058 , China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University , Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110 , 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