{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:09:14Z","timestamp":1780553354675,"version":"3.54.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801117"],"award-info":[{"award-number":["31801117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500400"],"award-info":[{"award-number":["2021YFC2500400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Municipal Health Commission Foundation","award":["RC20027"],"award-info":[{"award-number":["RC20027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Integration of accumulative large-scale single-cell transcriptomes requires scalable batch-correction approaches. Here we propose Fugue, a simple and efficient batch-correction method that is scalable for integrating super large-scale single-cell transcriptomes from diverse sources. The core idea of the method is to encode batch information as trainable parameters and add it to single-cell expression profile; subsequently, a contrastive learning approach is used to learn feature representation of the additive expression profile. We demonstrate the scalability of Fugue by integrating all single cells obtained from the Human Cell Atlas. We benchmark Fugue against current state-of-the-art methods and show that Fugue consistently achieves improved performance in terms of data alignment and clustering preservation. Our study will facilitate the integration of single-cell transcriptomes at increasingly large scale.<\/jats:p>","DOI":"10.1093\/bib\/bbac327","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T18:19:06Z","timestamp":1660155546000},"source":"Crossref","is-referenced-by-count":3,"title":["Scalable batch-correction approach for integrating large-scale single-cell transcriptomes"],"prefix":"10.1093","volume":"23","author":[{"given":"Xilin","family":"Shen","sequence":"first","affiliation":[{"name":"Tianjin Cancer Institute , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin 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University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Feng","sequence":"additional","affiliation":[{"name":"Tianjin Cancer Institute , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Hu","sequence":"additional","affiliation":[{"name":"Tianjin Cancer Institute , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilei","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Cancer Institute , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Cancer Institute , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Cancer Institute , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Cancer Institute , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, , Tianjin Medical University, Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology , The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, , Tianjin Medical University, Tianjin 300070 , China"},{"name":"Tianjin Medical University Cancer Institute and Hospital , The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, , Tianjin 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