{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:34:32Z","timestamp":1770420872467,"version":"3.49.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12101480"],"award-info":[{"award-number":["12101480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Basic Research Program of Shaanxi","award":["2021JM-115"],"award-info":[{"award-number":["2021JM-115"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JB210715"],"award-info":[{"award-number":["JB210715"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>RNA 5-hydroxymethylcytosine (5hmC) is a kind of RNA modification, which is related to the life activities of many organisms. Studying its distribution is very important to reveal its biological function. Previously, high-throughput sequencing was used to identify 5hmC, but it is expensive and inefficient. Therefore, machine learning is used to identify 5hmC sites. Here, we design a model called R5hmCFDV, which is mainly divided into feature representation, feature fusion and classification. (i) Pseudo dinucleotide composition, dinucleotide binary profile and frequency, natural vector and physicochemical property are used to extract features from four aspects: nucleotide composition, coding, natural language and physical and chemical properties. (ii) To strengthen the relevance of features, we construct a novel feature fusion method. Firstly, the attention mechanism is employed to process four single features, stitch them together and feed them to the convolution layer. After that, the output data are processed by BiGRU and BiLSTM, respectively. Finally, the features of these two parts are fused by the multiply function. (iii) We design the deep voting algorithm for classification by imitating the soft voting mechanism in the Python package. The base classifiers contain deep neural network (DNN), convolutional neural network (CNN) and improved gated recurrent unit (GRU). And then using the principle of soft voting, the corresponding weights are assigned to the predicted probabilities of the three classifiers. The predicted probability values are multiplied by the corresponding weights and then summed to obtain the final prediction results. We use 10-fold cross-validation to evaluate the model, and the evaluation indicators are significantly improved. The prediction accuracy of the two datasets is as high as 95.41% and 93.50%, respectively. It demonstrates the stronger competitiveness and generalization performance of our model. In addition, all datasets and source codes can be found at https:\/\/github.com\/HongyanShi026\/R5hmCFDV.<\/jats:p>","DOI":"10.1093\/bib\/bbac341","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T02:08:57Z","timestamp":1660097337000},"source":"Crossref","is-referenced-by-count":18,"title":["R5hmCFDV: computational identification of RNA 5-hydroxymethylcytosine based on deep feature fusion and deep voting"],"prefix":"10.1093","volume":"23","author":[{"given":"Hongyan","family":"Shi","sequence":"first","affiliation":[{"name":"School of Mathematics and Statistics, Xidian University , Xi\u2019an 710071, P. R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-0940","authenticated-orcid":false,"given":"Shengli","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Xidian University , Xi\u2019an 710071, P. R. China"}]},{"given":"Xinjie","family":"Li","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Xidian University , Xi\u2019an 710071, P. R. China"}]}],"member":"286","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"issue":"5","key":"2022092013225886200_ref1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/cbic.201500013","article-title":"Formation and abundance of 5-hydroxymethylcytosine in RNA","volume":"16","author":"Huber","year":"2015","journal-title":"Chembiochem"},{"issue":"7","key":"2022092013225886200_ref2","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA modifications in gene expression regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"issue":"12","key":"2022092013225886200_ref3","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1261\/rna.063503.117","article-title":"The RNA modification landscape in human disease","volume":"23","author":"Jonkhout","year":"2017","journal-title":"RNA"},{"issue":"2","key":"2022092013225886200_ref4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/bioinformatics\/btz556","article-title":"MM-6mAPred: identifying DNA N6-methyladenine sites based on Markov model","volume":"36","author":"Pian","year":"2020","journal-title":"Bioinformatics"},{"key":"2022092013225886200_ref5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.omtn.2019.08.022","article-title":"iRNA-m7G: identifying N7-methylguanosine sites by fusing multiple features","volume":"18","author":"Chen","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"2022092013225886200_ref6","doi-asserted-by":"crossref","first-page":"11112","DOI":"10.1038\/s41598-019-47594-7","article-title":"PACES: prediction of N4-acetylcytidine (ac4C) modification sites in mRNA","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci Rep"},{"issue":"16","key":"2022092013225886200_ref7","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1039\/C9CC00274J","article-title":"Bisulfite-free and base-resolution analysis of 5-methylcytidine and 5-hydroxymethylcytidine in RNA with peroxotungstate","volume":"55","author":"Yuan","year":"2019","journal-title":"Chem Commun (Camb)"},{"issue":"33","key":"2022092013225886200_ref8","doi-asserted-by":"crossref","first-page":"11582","DOI":"10.1021\/ja505305z","article-title":"Tet-mediated formation of 5-hydroxymethylcytosine in RNA","volume":"136","author":"Fu","year":"2014","journal-title":"J Am Chem Soc"},{"key":"2022092013225886200_ref9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fbioe.2020.00227","article-title":"iRNA5hmC: the first predictor to identify RNA 5-hydroxymethylcytosine modifications using machine learning","volume":"8","author":"Liu","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"2022092013225886200_ref10","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1109\/ACCESS.2021.3049146","article-title":"Prediction of RNA 5-hydroxyme-thylcytosine modifications using deep learning","volume":"9","author":"Ali","year":"2021","journal-title":"IEEE Access"},{"key":"2022092013225886200_ref11","doi-asserted-by":"crossref","first-page":"107583","DOI":"10.1016\/j.compbiolchem.2021.107583","article-title":"iR5hmcSC: Identifying RNA 5-hydroxymethylcytosine with multiple features based on stacking learning","volume":"95","author":"Zhang","year":"2021","journal-title":"Comput Biol Chem"},{"issue":"23","key":"2022092013225886200_ref12","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1093\/bioinformatics\/btz408","article-title":"Iterative feature representations improve N4-methylcytosine site prediction","volume":"35","author":"Wei","year":"2019","journal-title":"Bioinformatics"},{"issue":"5","key":"2022092013225886200_ref13","article-title":"A sequence-based deep learning approach to predict CTCF-mediated chromatin loop","volume":"22","author":"Lv","year":"2021","journal-title":"Brief Bioinform"},{"issue":"10","key":"2022092013225886200_ref14","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1093\/bioinformatics\/btaa074","article-title":"PmliPred: a method based on hybrid model and fuzzy decision for plant miRNA-lncRNA interaction prediction","volume":"36","author":"Kang","year":"2020","journal-title":"Bioinformatics"},{"issue":"20","key":"2022092013225886200_ref15","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1093\/bioinformatics\/bty356","article-title":"D3NER: biomedical named entity recognition using CRF-biLSTM improved with fine-tuned embeddings of various linguistic information","volume":"34","author":"Dang","year":"2018","journal-title":"Bioinformatics"},{"issue":"6270","key":"2022092013225886200_ref16","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1126\/science.aac5253","article-title":"RNA biochemistry. 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