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However, the roles of immune cell-specific lncRNAs in glioblastoma (GBM) remain largely unknown. In this study, a novel computational framework was constructed to screen the tumor-infiltrating immune cell-associated lncRNAs (TIIClnc) for developing TIIClnc signature by integratively analyzing the transcriptome data of purified immune cells, GBM cell lines and bulk GBM tissues using six machine learning algorithms. As a result, TIIClnc signature could distinguish survival outcomes of GBM patients across four independent datasets, including the Xiangya in-house dataset, and more importantly, showed superior performance than 95 previously established signatures in gliomas. TIIClnc signature was revealed to be an indicator of the infiltration level of immune cells and predicted the response outcomes of immunotherapy. The positive correlation between TIIClnc signature and CD8, PD-1 and PD-L1 was verified in the Xiangya in-house dataset. As a newly demonstrated predictive biomarker, the TIIClnc signature enabled a more precise selection of the GBM population who would benefit from immunotherapy and should be validated and applied in the near future.<\/jats:p>","DOI":"10.1093\/bib\/bbac386","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T16:32:27Z","timestamp":1663864347000},"source":"Crossref","is-referenced-by-count":78,"title":["Machine learning-based tumor-infiltrating immune cell-associated lncRNAs for predicting prognosis and immunotherapy response in patients with glioblastoma"],"prefix":"10.1093","volume":"23","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , China"},{"name":"Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University , China"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , China"},{"name":"One-third Lab, College of Bioinformatics Science and Technology, Harbin Medical University , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , China"}]},{"given":"Wantao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , China"},{"name":"Department of Oncology, Xiangya Hospital, Central South University , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , China"}]},{"given":"Ran","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester , 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Center for Geriatric Disorders, Xiangya Hospital, Central South University , China"}]},{"given":"Zaoqu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou , China"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Zhujiang Hospital, Southern Medical University , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-2045","authenticated-orcid":false,"given":"Peng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Zhujiang Hospital, Southern Medical University , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0288-6306","authenticated-orcid":false,"given":"Zhixiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 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