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The prerequisite for designing effective miRNA therapies is accurate discovery of miRNA-disease associations (MDAs), which has attracted substantial research interests during the last 15\u00a0years, as reflected by more than 55\u00a0000 related entries available on PubMed. Abundant experimental data gathered from the wealth of literature could effectively support the development of computational models for predicting novel associations. In 2017, Chen et\u00a0al. published the first-ever comprehensive review on MDA prediction, presenting various relevant databases, 20 representative computational models, and suggestions for building more powerful ones. In the current review, as the continuation of the previous study, we revisit miRNA biogenesis, detection techniques and functions; summarize recent experimental findings related to common miRNA-associated diseases; introduce recent updates of miRNA-relevant databases and novel database releases since 2017, present mainstream webservers and new webserver releases since 2017 and finally elaborate on how fusion of diverse data sources has contributed to accurate MDA prediction.<\/jats:p>","DOI":"10.1093\/bib\/bbac397","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T11:55:05Z","timestamp":1662983705000},"source":"Crossref","is-referenced-by-count":92,"title":["Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion"],"prefix":"10.1093","volume":"23","author":[{"given":"Li","family":"Huang","sequence":"first","affiliation":[{"name":"Academy of Arts and Design, Tsinghua University , Beijing, 10084, China"},{"name":"The Future Laboratory, Tsinghua University , Beijing, 10084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Information and Control Engineering, China University of Mining and Technology , Xuzhou, 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-7174","authenticated-orcid":false,"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Information and Control Engineering, China University of Mining and Technology , Xuzhou, 221116, China"},{"name":"Artificial Intelligence Research Institute, China University of Mining and Technology , Xuzhou, 221116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"2022112111111743400_ref1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"2022112111111743400_ref2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Lagos-Quintana","year":"2001","journal-title":"Science"},{"key":"2022112111111743400_ref3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1065062","article-title":"An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis 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