{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:57:28Z","timestamp":1776913048252,"version":"3.51.2"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62072173"],"award-info":[{"award-number":["62072173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province, China","doi-asserted-by":"crossref","award":["2020JJ4432"],"award-info":[{"award-number":["2020JJ4432"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Scientific Research Projects of Department of Education of Hunan Province","award":["20A296"],"award-info":[{"award-number":["20A296"]}]},{"name":"Key open project of Key Laboratory of Data Science and Intelligence Education"},{"DOI":"10.13039\/501100011821","name":"Ministry of Education","doi-asserted-by":"publisher","award":["DSIE202101"],"award-info":[{"award-number":["DSIE202101"]}],"id":[{"id":"10.13039\/501100011821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFB2104400"],"award-info":[{"award-number":["2020YFB2104400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical humanities and Social Sciences project of Hunan Normal University"},{"name":"Innovation & Entrepreneurship Training Program of Hunan Xiangjiang Artificial Intelligence Academy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Imaging genetics provides unique insights into the pathological studies of complex brain diseases by integrating the characteristics of multi-level medical data. However, most current imaging genetics research performs incomplete data fusion. Also, there is a lack of effective deep learning methods to analyze neuroimaging and genetic data jointly. Therefore, this paper first constructs the brain region-gene networks to intuitively represent the association pattern of pathogenetic factors. Second, a novel feature information aggregation model is constructed to accurately describe the information aggregation process among brain region nodes and gene nodes. Finally, a deep learning method called feature information aggregation and diffusion generative adversarial network (FIAD-GAN) is proposed to efficiently classify samples and select features. We focus on improving the generator with the proposed convolution and deconvolution operations, with which the interpretability of the deep learning framework has been dramatically improved. The experimental results indicate that FIAD-GAN can not only achieve superior results in various disease classification tasks but also extract brain regions and genes closely related to AD. This work provides a novel method for intelligent clinical decisions. The relevant biomedical discoveries provide a reliable reference and technical basis for the clinical diagnosis, treatment and pathological analysis of disease.<\/jats:p>","DOI":"10.1093\/bib\/bbac454","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T08:47:05Z","timestamp":1666169225000},"source":"Crossref","is-referenced-by-count":6,"title":["A novel generation adversarial network framework with characteristics aggregation and diffusion for brain disease classification and feature selection"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2715-3360","authenticated-orcid":false,"given":"Xia-an","family":"Bi","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing, and College of Information Science and Engineering in Hunan Normal University , Changsha, P.R. 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