{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:35:52Z","timestamp":1785609352449,"version":"3.56.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770821"],"award-info":[{"award-number":["31770821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071430"],"award-info":[{"award-number":["32071430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Training Program of Innovation and Entrepreneurship for Undergraduates","award":["S202011065118"],"award-info":[{"award-number":["S202011065118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The unique chemical reactivity of cysteine residues results in various posttranslational modifications (PTMs), which are implicated in regulating a range of fundamental biological processes. With the advent of chemical proteomics technology, thousands of cysteine PTM (CysPTM) sites have been identified from multiple species. A few CysPTM-based databases have been developed, but they mainly focus on data collection rather than various annotations and analytical integration. Here, we present a platform-dubbed CysModDB, integrated with the comprehensive CysPTM resources and analysis tools. CysModDB contains five parts: (1) 70\u00a0536 experimentally verified CysPTM sites with annotations of sample origin and enrichment techniques, (2) 21\u00a0654 modified proteins annotated with functional regions and structure information, (3) cross-references to external databases such as the protein\u2013protein interactions database, (4) online computational tools for predicting CysPTM sites and (5) integrated analysis tools such as gene enrichment and investigation of sequence features. These parts are integrated using a customized graphic browser and a Basket. The browser uses graphs to represent the distribution of modified sites with different CysPTM types on protein sequences and mapping these sites to the protein structures and functional regions, which assists in exploring cross-talks between the modified sites and their potential effect on protein functions. The Basket connects proteins and CysPTM sites to the analysis tools. In summary, CysModDB is an integrated platform to facilitate the CysPTM research, freely accessible via https:\/\/cysmoddb.bioinfogo.org\/.<\/jats:p>","DOI":"10.1093\/bib\/bbac460","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T12:33:46Z","timestamp":1666960426000},"source":"Crossref","is-referenced-by-count":16,"title":["CysModDB: a comprehensive platform with the integration of manually curated resources and analysis tools for cysteine posttranslational modifications"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-9635","authenticated-orcid":false,"given":"Yanzheng","family":"Meng","sequence":"first","affiliation":[{"name":"Faculty of Biomedical and Rehabilitation Engineering, University of Health and Rehabilitation Sciences , Qingdao, China"},{"name":"School of Basic Medicine, Qingdao University , Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3902-6083","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Computer Science and Technology, Qingdao University , Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laizhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao University , Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Qingdao University , Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanwen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Computer Science and Technology, Qingdao University , Qingdao, 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