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Vir2Drug is a drug repurposing tool that uses network-based approaches to identify and rank candidate drugs for a specific pathogen, combining information obtained from: (a) ranked pathogen-to-pathogen networks based on protein similarities between pathogens, (b) taxonomy distance between pathogens and (c) drugs targeting specific pathogen\u2019s and host proteins. The underlying pathogen networks are used to screen drugs by means of specific methodologies that account for either the host or pathogen\u2019s protein targets. Vir2Drug is a useful and yet informative tool for drug repurposing against known or unknown pathogens especially in periods where the emergence for repurposed drugs plays significant role in handling viral outbreaks, until reaching a vaccine. The web tool is available at: https:\/\/bioinformatics.cing.ac.cy\/vir2drug, https:\/\/vir2drug.cing-big.hpcf.cyi.ac.cy<\/jats:p>","DOI":"10.1093\/bib\/bbac536","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:46:43Z","timestamp":1670978803000},"source":"Crossref","is-referenced-by-count":2,"title":["Vir2Drug: a drug repurposing framework based on protein similarities between pathogens"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-2208","authenticated-orcid":false,"given":"George","family":"Minadakis","sequence":"first","affiliation":[{"name":"The Cyprus Institute of Neurology & Genetics Bioinformatics Department, , 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus | PO Box 23462, 1683 Nicosia, Cyprus"},{"name":"The Cyprus School of Molecular Medicine , 6 Iroon Avenue, 2371 Ayios Dometios, PO Box 23462, 1683 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios","family":"Tomazou","sequence":"additional","affiliation":[{"name":"The Cyprus Institute of Neurology & Genetics Bioinformatics Department, , 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus | PO Box 23462, 1683 Nicosia, Cyprus"},{"name":"The Cyprus School of Molecular Medicine , 6 Iroon Avenue, 2371 Ayios Dometios, PO Box 23462, 1683 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolas","family":"Dietis","sequence":"additional","affiliation":[{"name":"University of Cyprus Medical School, , Nicosia 1678, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-3363","authenticated-orcid":false,"given":"George M","family":"Spyrou","sequence":"additional","affiliation":[{"name":"The Cyprus Institute of Neurology & Genetics Bioinformatics Department, , 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus | PO Box 23462, 1683 Nicosia, Cyprus"},{"name":"The Cyprus School of Molecular Medicine , 6 Iroon Avenue, 2371 Ayios Dometios, PO Box 23462, 1683 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"2023011917140360600_ref1","doi-asserted-by":"crossref","DOI":"10.1080\/1744666X.2021.1912596","article-title":"Perspective: the nose and the stomach play a critical role in the NZACE2-P\u0101tari*(modified ACE2) drug treatment project of SARS-CoV-2 infection","volume":"17","author":"Ameratunga","year":"2021","journal-title":"Expert Rev Clin Immunol"},{"key":"2023011917140360600_ref2","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.2174\/0929867325666180530100332","article-title":"Computational drug repurposing: current trends","volume":"26","author":"Karaman","year":"2019","journal-title":"Curr Med 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