{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:49:38Z","timestamp":1778586578146,"version":"3.51.4"},"reference-count":98,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sailing Program of Naval Medical University"},{"name":"Three-year Action Plan for Shanghai TCM Development and Inheritance Program","award":["ZY(2021-2023)-0401"],"award-info":[{"award-number":["ZY(2021-2023)-0401"]}]},{"name":"Shanghai Frontiers Science Center of TCM Chemical Biology, Shanghai Municipal Health Commission Project","award":["20204Y0326"],"award-info":[{"award-number":["20204Y0326"]}]},{"name":"Shanghai Sailing Program","award":["20YF1459000"],"award-info":[{"award-number":["20YF1459000"]}]},{"name":"Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine","award":["ZYYCXTD-D-202004"],"award-info":[{"award-number":["ZYYCXTD-D-202004"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004215"],"award-info":[{"award-number":["82004215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004003"],"award-info":[{"award-number":["82004003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141203"],"award-info":[{"award-number":["82141203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFE0200900"],"award-info":[{"award-number":["2021YFE0200900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3502000"],"award-info":[{"award-number":["2022YFC3502000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the emergence of high-throughput technologies, computational screening based on gene expression profiles has become one of the most effective methods for drug discovery. More importantly, profile-based approaches remarkably enhance novel drug\u2013disease pair discovery without relying on drug- or disease-specific prior knowledge, which has been widely used in modern medicine. However, profile-based systematic screening of active ingredients of traditional Chinese medicine (TCM) has been scarcely performed due to inadequate pharmacotranscriptomic data. Here, we develop the largest-to-date online TCM active ingredients-based pharmacotranscriptomic platform integrated traditional Chinese medicine (ITCM) for the effective screening of active ingredients. First, we performed unified high-throughput experiments and constructed the largest data repository of 496 representative active ingredients, which was five times larger than the previous one built by our team. The transcriptome-based multi-scale analysis was also performed to elucidate their mechanism. Then, we developed six state-of-art signature search methods to screen active ingredients and determine the optimal signature size for all methods. Moreover, we integrated them into a screening strategy, TCM-Query, to identify the potential active ingredients for the special disease. In addition, we also comprehensively collected the TCM-related resource by literature mining. Finally, we applied ITCM to an active ingredient bavachinin, and two diseases, including prostate cancer and COVID-19, to demonstrate the power of drug discovery. ITCM was aimed to comprehensively explore the active ingredients of TCM and boost studies of pharmacological action and drug discovery. ITCM is available at http:\/\/itcm.biotcm.net.<\/jats:p>","DOI":"10.1093\/bib\/bbad027","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T22:08:15Z","timestamp":1675202895000},"source":"Crossref","is-referenced-by-count":109,"title":["Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-190X","authenticated-orcid":false,"given":"Saisai","family":"Tian","sequence":"first","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8287-3259","authenticated-orcid":false,"given":"Jinbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"},{"name":"Tianjin Rehabilitation Center of Joint Logistics Support Force Department of Pharmacy, , Tianjin, 300110, China"}]},{"given":"Shunling","family":"Yuan","sequence":"additional","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"}]},{"given":"Chao","family":"Lv","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"}]},{"given":"Jinxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"}]},{"given":"Jiansong","family":"Fang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine Science and Technology Innovation Center, , Guangzhou, China"}]},{"given":"Lu","family":"Fu","sequence":"additional","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"}]},{"given":"Xianpeng","family":"Zu","sequence":"additional","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"},{"name":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"}]}],"member":"286","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12016-012-8332-0","article-title":"Traditional Chinese medicine and immune regulation","volume":"44","author":"Ma","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1016\/j.jacc.2017.04.041","article-title":"Traditional Chinese medicine for cardiovascular disease: evidence and potential mechanisms","volume":"69","author":"Hao","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"109570","DOI":"10.1016\/j.biopha.2019.109570","article-title":"Antitumor effects of immunity-enhancing traditional Chinese medicine","volume":"121","author":"Wang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"104743","DOI":"10.1016\/j.phrs.2020.104743","article-title":"Traditional Chinese medicine for COVID-19 treatment","volume":"155","author":"Ren","year":"2020","journal-title":"Pharmacol Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1002\/anie.201601967","article-title":"Artemisinin-a gift from traditional Chinese medicine to the world (Nobel lecture)","volume":"55","author":"Tu","year":"2016","journal-title":"Angew Chem Int Ed Engl"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1039\/C8FO01696H","article-title":"The in silico and in vivo evaluation of puerarin against Alzheimer\u2019s disease","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1021\/acsnano.0c00708","article-title":"Icaritin exacerbates mitophagy and synergizes with doxorubicin to induce immunogenic cell death in hepatocellular carcinoma","volume":"14","author":"Yu","year":"2020","journal-title":"ACS Nano"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"474267","DOI":"10.3389\/fphar.2021.474267","article-title":"The advantages of connectivity map applied in traditional Chinese medicine","volume":"12","author":"Jiang","year":"2021","journal-title":"Front Pharmacol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmpb.2018.04.002","article-title":"Exploring the molecular mechanisms of traditional Chinese medicine components using gene expression signatures and connectivity map","volume":"174","author":"Yoo","year":"2019","journal-title":"Comput Methods Programs Biomed"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fonc.2019.00224","article-title":"Antiproliferative effects of the natural oxadiazine nocuolin A are associated with impairment of mitochondrial oxidative phosphorylation","volume":"9","author":"Sousa","year":"2019","journal-title":"Front Oncol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cmet.2021.02.007","article-title":"The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity","volume":"33","author":"Chen","year":"2021","journal-title":"Cell Metab"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41598-017-00535-8","article-title":"The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMs","volume":"7","author":"Lv","year":"2017","journal-title":"Sci Rep"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41401-019-0240-x","article-title":"Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail\/Slug protein translation","volume":"40","author":"Wang","year":"2019","journal-title":"Acta Pharmacol Sin"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0229-z","article-title":"Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K\/Akt signaling pathway","volume":"51","author":"Luo","year":"2019","journal-title":"Exp Mol Med"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"E91","DOI":"10.3390\/cancers11010091","article-title":"The potential mechanism of bufadienolide-like chemicals on breast cancer via bioinformatics analysis","volume":"11","author":"Zhang","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ebiom.2018.10.041","article-title":"Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction","volume":"37","author":"Zhong","year":"2018","journal-title":"EBioMedicine"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41419-017-0247-5","article-title":"The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG","volume":"9","author":"Lv","year":"2018","journal-title":"Cell Death Dis"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.omto.2021.12.025","article-title":"Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells","volume":"24","author":"Lv","year":"2022","journal-title":"Mol Ther Oncolytics"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"899402","DOI":"10.3389\/fonc.2022.899402","article-title":"Andrographolide inhibits ER-positive breast cancer growth and enhances fulvestrant efficacy via ROS-FOXM1-ER-\u03b1 axis","volume":"12","author":"Xu","year":"2022","journal-title":"Front Oncol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/ph15020179","article-title":"Bruceine D identified as a drug candidate against breast cancer by a novel drug selection pipeline and cell viability assay","volume":"15","author":"Cipriani","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"bbab542","DOI":"10.1093\/bib\/bbab542","article-title":"TMNP: a transcriptome-based multi-scale network pharmacology platform for herbal medicine","volume":"23","author":"Li","year":"2022","journal-title":"Brief Bioinform"},{"key":"2023032004371720600_","first-page":"61","article-title":"ClassyFire: automated chemical classification with a comprehensive, computable taxonomy","volume":"8","author":"Djoumbou Feunang","year":"2016","journal-title":"J Chem"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"e71880","DOI":"10.7554\/eLife.71880","article-title":"A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer","volume":"11","author":"Yang","year":"2022","journal-title":"Elife"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1038\/s41467-018-07232-8","article-title":"Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas","volume":"9","author":"Rosario","year":"2018","journal-title":"Nat Commun"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1093\/nar\/gkt111","article-title":"Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods","volume":"41","author":"V\u00e4remo","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/bioinformatics\/btt592","article-title":"gCMAP: user-friendly connectivity mapping with R","volume":"30","author":"Sandmann","year":"2014","journal-title":"Bioinformatics"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1471-2105-9-258","article-title":"A simple and robust method for connecting small-molecule drugs using gene-expression signatures","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2307\/2982890","article-title":"Fisher\u2019s exact test","volume":"155","author":"Upton GJG","year":"1992","journal-title":"J R Stat Soc A"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00442-018-4233-0","article-title":"Underestimation of Pearson\u2019s product moment correlation statistic","volume":"189","author":"Humphreys","year":"2019","journal-title":"Oecologia"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/bioinformatics\/btr709","article-title":"Robust rank aggregation for gene list integration and meta-analysis","volume":"28","author":"Kolde","year":"2012","journal-title":"Bioinformatics"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bib\/bbz129","article-title":"A comprehensive evaluation of connectivity methods for L1000 data","volume":"21","author":"Lin","year":"2020","journal-title":"Brief Bioinform"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1110","DOI":"10.1093\/nar\/gky1021","article-title":"SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping","volume":"47","author":"Wu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1089","DOI":"10.1093\/nar\/gks1100","article-title":"TCMID: traditional Chinese medicine integrative database for herb molecular mechanism analysis","volume":"41","author":"Xue","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1117","DOI":"10.1093\/nar\/gkx1028","article-title":"TCMID 2.0: a comprehensive resource for TCM","volume":"46","author":"Huang","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","first-page":"13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J Chem"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D976","DOI":"10.1093\/nar\/gky987","article-title":"ETCM: an encyclopaedia of traditional Chinese medicine","volume":"47","author":"Xu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1217","DOI":"10.1093\/nar\/gkx1026","article-title":"NPASS: natural product activity and species source database for natural product research, discovery and tool development","volume":"46","author":"Zeng","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1118","DOI":"10.1093\/nar\/gky965","article-title":"CMAUP: a database of collective molecular activities of useful plants","volume":"47","author":"Zeng","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fphar.2020.00439","article-title":"TCMIO: a comprehensive database of traditional Chinese medicine on immuno-oncology","volume":"11","author":"Liu","year":"2020","journal-title":"Front Pharmacol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0706945","article-title":"Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation","volume":"149","author":"Chen","year":"2006","journal-title":"Br J Pharmacol"},{"key":"2023032004371720600_","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1068","DOI":"10.1093\/nar\/gkx1143","article-title":"DGIdb 3.0: a redesign and expansion of the drug\u2013gene interaction database","volume":"46","author":"Cotto","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"D1138","DOI":"10.1093\/nar\/gkaa891","article-title":"Comparative Toxicogenomics Database (CTD): update 2021","volume":"49","author":"Davis","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41587-021-01016-0","article-title":"AI drug discovery booms in China","volume":"39","author":"Cyranoski","year":"2021","journal-title":"Nat Biotechnol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"R70","DOI":"10.1186\/gb-2003-4-10-r70","article-title":"Identifying biological themes within lists of genes with EASE","volume":"4","author":"Hosack","year":"2003","journal-title":"Genome Biol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1038\/ncomms7522","article-title":"Ainsliadimer A selectively inhibits IKK\u03b1\/\u03b2 by covalently binding a conserved cysteine","volume":"6","author":"Dong","year":"2015","journal-title":"Nat Commun"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"6677687","DOI":"10.1155\/2021\/6677687","article-title":"The Cyr61 is a potential target for rotundifuran, a natural labdane-type diterpene from Vitex trifolia L., to trigger apoptosis of cervical cancer cells","volume":"2021","author":"Gong","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2020.02.022","article-title":"Acetyl-11-keto-\u03b2-boswellic acid ameliorates cognitive deficits and reduces amyloid-\u03b2 levels in APPswe\/PS1dE9 mice through antioxidant and anti-inflammatory pathways","volume":"150","author":"Wei","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"173893","DOI":"10.1016\/j.ejphar.2021.173893","article-title":"Gypenoside XVII alleviates early diabetic retinopathy by regulating M\u00fcller cell apoptosis and autophagy in db\/db mice","volume":"895","author":"Luo","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"108850","DOI":"10.1016\/j.biopha.2019.108850","article-title":"Preliminary studies on the anti-osteoporosis activity of Baohuoside I","volume":"115","author":"Xi","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"104624","DOI":"10.1016\/j.phrs.2019.104624","article-title":"Nitidine chloride exerts anti-inflammatory action by targeting topoisomerase I and enhancing IL-10 production (vol 148, 104368, 2019)","volume":"153","author":"Yang","year":"2020","journal-title":"Pharmacol Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/jssc.201900229","article-title":"Comprehensive characterization of multiple components and metabolites of Xiaojin Capsule based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry","volume":"42","author":"Qi","year":"2019","journal-title":"J Sep Sci"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"153330","DOI":"10.1016\/j.phymed.2020.153330","article-title":"Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation","volume":"79","author":"Cheng","year":"2020","journal-title":"Phytomedicine"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"113460","DOI":"10.1016\/j.jep.2020.113460","article-title":"Quantitative proteomics reveals Shexiang Baoxin Pill exerts cardioprotective effects by preserving energy metabolism in a rat model of myocardial infarction","volume":"266","author":"Yu","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.chroma.2008.12.032","article-title":"Advancement in analysis of Salviae miltiorrhizae Radix et Rhizoma (Danshen)","volume":"1216","author":"Li","year":"2009","journal-title":"J Chromatogr A"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s10555-021-10006-2","article-title":"The role of metabolic ecosystem in cancer progression - metabolic plasticity and mTOR hyperactivity in tumor tissues","volume":"40","author":"Sebesty\u00e9n","year":"2021","journal-title":"Cancer Metastasis Rev"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12016-013-8402-y","article-title":"TLR2 and TLR4 in autoimmune diseases: a comprehensive review","volume":"47","author":"Liu","year":"2014","journal-title":"Clin Rev Allergy Immunol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/cmi.2013.27","article-title":"Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs","volume":"10","author":"Chen","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.euo.2021.09.006","article-title":"Epidemiology and prevention of prostate cancer","volume":"4","author":"Gandaglia","year":"2021","journal-title":"Eur Urol Oncol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pharmthera.2013.07.003","article-title":"Androgen receptors in hormone-dependent and castration-resistant prostate cancer","volume":"140","author":"Shafi","year":"2013","journal-title":"Pharmacol Ther"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1534735416645408","article-title":"In vitro and in vivo efficacy studies of Lavender angustifolia essential oil and its active constituents on the proliferation of human prostate cancer","volume":"16","author":"Zhao","year":"2017","journal-title":"Integr Cancer Ther"},{"key":"2023032004371720600_","first-page":"1","article-title":"Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis","volume":"20","author":"Zhao","year":"2020","journal-title":"Oncol Lett"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41419-018-0575-0","article-title":"Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"E380","DOI":"10.3390\/ijms19020380","article-title":"Corylin suppresses hepatocellular carcinoma progression via the inhibition of epithelial-mesenchymal transition, mediated by Long noncoding RNA GAS5","volume":"19","author":"Chen","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"153366","DOI":"10.1016\/j.phymed.2020.153366","article-title":"Effect of the isoflavone corylin from Cullen corylifolium on colorectal cancer growth, by targeting the STAT3 signaling pathway","volume":"80","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fct.2014.08.002","article-title":"Blockade of epidermal growth factor receptor\/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells","volume":"73","author":"Geng","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1016\/j.fct.2012.06.027","article-title":"Icariside II potentiates paclitaxel-induced apoptosis in human melanoma A375 cells by inhibiting TLR4 signaling pathway","volume":"50","author":"Wu","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"102154","DOI":"10.1016\/j.ctrv.2021.102154","article-title":"MYC as a target for cancer treatment","volume":"94","author":"Duffy","year":"2021","journal-title":"Cancer Treat Rev"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"113137","DOI":"10.1016\/j.ejmech.2020.113137","article-title":"Targeting MYC: from understanding its biology to drug discovery","volume":"213","author":"Ross","year":"2021","journal-title":"Eur J Med Chem"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"e87003","DOI":"10.1371\/journal.pone.0087003","article-title":"Regulation of MYC expression and differential JQ1 sensitivity in cancer cells","volume":"9","author":"Fowler","year":"2014","journal-title":"PLoS One"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","article-title":"BET bromodomain inhibition as a therapeutic strategy to target c-Myc","volume":"146","author":"Delmore","year":"2011","journal-title":"Cell"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/2040620715576662","article-title":"Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidence","volume":"6","author":"Chaidos","year":"2015","journal-title":"Ther Adv Hematol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.it.2020.10.004","article-title":"Mechanisms of SARS-CoV-2 transmission and pathogenesis","volume":"41","author":"Harrison","year":"2020","journal-title":"Trends Immunol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cytogfr.2020.05.002","article-title":"COVID-19: pathogenesis, cytokine storm and therapeutic potential of interferons","volume":"53","author":"Nile","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.clnu.2013.03.001","article-title":"Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease","volume":"33","author":"Mayneris-Perxachs","year":"2014","journal-title":"Clin Nutr"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1128\/AAC.00041-07","article-title":"Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis","volume":"51","author":"Swarup","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fsi.2019.10.055","article-title":"Antiviral activity of palmitic acid via autophagic flux inhibition in zebrafish (Danio rerio)","volume":"95","author":"Libr\u00e1n-P\u00e9rez","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1080\/22221751.2020.1767512","article-title":"Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors","volume":"9","author":"Hsieh","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"153317","DOI":"10.1016\/j.phymed.2020.153317","article-title":"Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication","volume":"85","author":"Kumar","year":"2021","journal-title":"Phytomedicine"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1080\/14756366.2018.1493472","article-title":"Rapidly screening of \u03b1-glucosidase inhibitors from Dioscorea opposita Thunb. peel based on rGO@Fe3O4 nanocomposites microreactor","volume":"33","author":"Zhang","year":"2018","journal-title":"J Enzyme Inhib Med Chem"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1042\/BST20200505","article-title":"\u03b1-Glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19","volume":"48","author":"Williams","year":"2020","journal-title":"Biochem Soc Trans"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.apsb.2020.10.002","article-title":"Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening","volume":"11","author":"Chen","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1186\/s13054-020-03120-0","article-title":"Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19","volume":"24","author":"Ni","year":"2020","journal-title":"Crit Care"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/med.21776","article-title":"Therapeutic targets and potential agents for the treatment of COVID-19","volume":"41","author":"Wu","year":"2021","journal-title":"Med Res Rev"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/biom11040607","article-title":"SARS-CoV-2 Mpro: a potential target for peptidomimetics and small-molecule inhibitors","volume":"11","author":"Citarella","year":"2021","journal-title":"Biomolecules"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cell.2022.01.001","article-title":"Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2","volume":"185","author":"Han","year":"2022","journal-title":"Cell"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41594-020-0469-6","article-title":"Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2","volume":"27","author":"Huo","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"e70658","DOI":"10.7554\/eLife.70658","article-title":"Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics","volume":"10","author":"Barton","year":"2021","journal-title":"Elife"},{"key":"2023032004371720600_","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/24\/2\/bbad027\/49560626\/bbad027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/24\/2\/bbad027\/49560626\/bbad027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T18:26:53Z","timestamp":1679336813000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbad027\/7017365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":98,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3,19]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbad027","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3]]},"published":{"date-parts":[[2023,1,31]]},"article-number":"bbad027"}}