{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:17:58Z","timestamp":1783991878280,"version":"3.55.0"},"reference-count":132,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32125033"],"award-info":[{"award-number":["32125033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug resistance is increasingly among the main issues affecting human health and threatening agriculture and food security. In particular, developing approaches to overcome target mutation-induced drug resistance has long been an essential part of biological research. During the past decade, many bioinformatics tools have been developed to explore this type of drug resistance, and they have become popular for elucidating drug resistance mechanisms in a low cost, fast and effective way. However, these resources are scattered and underutilized, and their strengths and limitations have not been systematically analyzed and compared. Here, we systematically surveyed 59 freely available bioinformatics tools for exploring target mutation-induced drug resistance. We analyzed and summarized these resources based on their functionality, data volume, data source, operating principle, performance, etc. And we concisely discussed the strengths, limitations and application examples of these tools. Specifically, we tested some predictive tools and offered some thoughts from the clinician\u2019s perspective. Hopefully, this work will provide a useful toolbox for researchers working in the biomedical, pesticide, bioinformatics and pharmaceutical engineering fields, and a good platform for non-specialists to quickly understand drug resistance prediction.<\/jats:p>","DOI":"10.1093\/bib\/bbad033","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T12:10:20Z","timestamp":1675512620000},"source":"Crossref","is-referenced-by-count":10,"title":["Bioinformatics toolbox for exploring target mutation-induced drug resistance"],"prefix":"10.1093","volume":"24","author":[{"given":"Yuan-Qin","family":"Huang","sequence":"first","affiliation":[{"name":"National Key Laboratory of Green Pesticide , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"},{"name":"Guizhou University , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Green Pesticide , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"},{"name":"Guizhou University , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Green Pesticide , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"},{"name":"Guizhou University , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-3667","authenticated-orcid":false,"given":"Huan-Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Applied Science, Macao Polytechnic University , Macao 999078, SAR , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge-Fei","family":"Hao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Green Pesticide , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"},{"name":"Guizhou University , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-An","family":"Song","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Green Pesticide , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"},{"name":"Guizhou University , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, , Guiyang 550025 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,4]]},"reference":[{"key":"2023032004363121300_","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"2023032004363121300_","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nrmicro2693","article-title":"Tackling antibiotic resistance","volume":"9","author":"Bush","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"2023032004363121300_","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.aap7999","article-title":"Worldwide emergence of resistance to antifungal drugs challenges human health and food 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