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Due to the complex mechanism of herbal actions, it is challenging to discover effective herbal formulas for diseases by integrating the traditional experiences and modern pharmacological mechanisms of multi-target interactions. In this study, we propose a herbal formula prediction approach (TCMFP) combined therapy experience of TCM, artificial intelligence and network science algorithms to screen optimal herbal formula for diseases efficiently, which integrates a herb score (Hscore) based on the importance of network targets, a pair score (Pscore) based on empirical learning and herbal formula predictive score (FmapScore) based on intelligent optimization and genetic algorithm. The validity of Hscore, Pscore and FmapScore was verified by functional similarity and network topological evaluation. Moreover, TCMFP was used successfully to generate herbal formulae for three diseases, i.e. the Alzheimer\u2019s disease, asthma and atherosclerosis. Functional enrichment and network analysis indicates the efficacy of targets for the predicted optimal herbal formula. The proposed TCMFP may provides a new strategy for the optimization of herbal formula, TCM herbs therapy and drug development.<\/jats:p>","DOI":"10.1093\/bib\/bbad102","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T02:26:37Z","timestamp":1679365597000},"source":"Crossref","is-referenced-by-count":43,"title":["TCMFP: a novel herbal formula prediction method based on network target\u2019s score integrated with semi-supervised learning genetic algorithms"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-7985","authenticated-orcid":false,"given":"Qikai","family":"Niu","sequence":"first","affiliation":[{"name":"China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica, , Beijing 100700 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Institute of 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