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Precise identification of RNA modification sites is thus crucial for understanding the related molecular functions and specific regulatory circuitry. To date, a number of computational approaches have been developed for in silico identification of RNA modification sites; however, most of them require learning from base-resolution epitranscriptome datasets, which are generally scarce and available only for a limited number of experimental conditions, and predict only a single modification, even though there are multiple inter-related RNA modification types available. In this study, we proposed AdaptRM, a multi-task computational method for synergetic learning of multi-tissue, type and species RNA modifications from both high- and low-resolution epitranscriptome datasets. By taking advantage of adaptive pooling and multi-task learning, the newly proposed AdaptRM approach outperformed the state-of-the-art computational models (WeakRM and TS-m6A-DL) and two other deep-learning architectures based on Transformer and ConvMixer in three different case studies for both high-resolution and low-resolution prediction tasks, demonstrating its effectiveness and generalization ability. In addition, by interpreting the learned models, we unveiled for the first time the potential association between different tissues in terms of epitranscriptome sequence patterns. AdaptRM is available as a user-friendly web server from http:\/\/www.rnamd.org\/AdaptRM together with all the codes and data used in this project.<\/jats:p>","DOI":"10.1093\/bib\/bbad105","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T05:56:32Z","timestamp":1679118992000},"source":"Crossref","is-referenced-by-count":19,"title":["Multi-task adaptive pooling enabled synergetic learning of RNA modification across tissue, type and species from low-resolution epitranscriptomes"],"prefix":"10.1093","volume":"24","author":[{"given":"Yiyou","family":"Song","sequence":"first","affiliation":[{"name":"Department of Biological Sciences"},{"name":"Department of Computer Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, School of AI and Advanced Computing"},{"name":"Department of Computer Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiyun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences"},{"name":"AI University Research Centre, Xi'an Jiaotong-Liverpool University , Suzhou 215123 , PR China"},{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool L69 7ZB , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"2023052021592195600_ref1","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.csbj.2020.06.010","article-title":"Bioinformatics approaches for deciphering the epitranscriptome: recent progress and emerging topics","volume":"18","author":"Liu","year":"2020","journal-title":"Comput Struct Biotechnol J"},{"issue":"5","key":"2023052021592195600_ref2","first-page":"e1595","article-title":"Naturally occurring modified ribonucleosides. 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