{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:26:34Z","timestamp":1782401194042,"version":"3.54.5"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Natural Science Foundation of Changsha","award":["2022ZD0213700"],"award-info":[{"award-number":["2022ZD0213700"]}]},{"name":"Natural Science Foundation of Changsha","award":["kq2202105"],"award-info":[{"award-number":["kq2202105"]}]},{"name":"High Performance Computing Center of Central South University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alternative splicing (AS) is a key transcriptional regulation pathway. Recent studies have shown that AS events are associated with the occurrence of complex diseases. Various computational approaches have been developed for the detection of disease-associated AS events. In this review, we first describe the metrics used for quantitative characterization of AS events. Second, we review and discuss the three types of methods for detecting disease-associated splicing events, which are differential splicing analysis, aberrant splicing detection and splicing-related network analysis. Third, to further exploit the genetic mechanism of disease-associated AS events, we describe the methods for detecting genetic variants that potentially regulate splicing. For each type of methods, we conducted experimental comparison to illustrate their performance. Finally, we discuss the limitations of these methods and point out potential ways to address them. We anticipate that this review provides a systematic understanding of computational approaches for the analysis of disease-associated splicing.<\/jats:p>","DOI":"10.1093\/bib\/bbad106","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T03:39:50Z","timestamp":1680147590000},"source":"Crossref","is-referenced-by-count":9,"title":["Computational approaches for detecting disease-associated alternative splicing events"],"prefix":"10.1093","volume":"24","author":[{"given":"Jiashu","family":"Liu","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, Hunan Provincial Key Lab on Bioinformatics, Central South University , Changsha, Hunan 410083 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Xiang","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Hunan Provincial Key Lab on Bioinformatics, Central South University , Changsha, Hunan 410083 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Hunan Provincial Key Lab on Bioinformatics, Central South University , Changsha, Hunan 410083 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Hunan Provincial Key Lab on Bioinformatics, Central South University , Changsha, Hunan 410083 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkui","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Hunan Provincial Key Lab on Bioinformatics, Central South University , Changsha, Hunan 410083 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Hunan Provincial Key Lab on Bioinformatics, Central South University , Changsha, Hunan 410083 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine and Bioinformatics, University of Michigan , Ann Arbor, MI 48109 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-739X","authenticated-orcid":false,"given":"Hong-Dong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Hunan Provincial Key Lab on Bioinformatics, Central South University , Changsha, Hunan 410083 , P.R. 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