{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:51:28Z","timestamp":1771606288254,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2682021ZTPY110"],"award-info":[{"award-number":["2682021ZTPY110"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61976247"],"award-info":[{"award-number":["61976247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Identifying protein\u2013protein interaction (PPI) site is an important step in understanding biological activity, apprehending pathological mechanism and designing novel drugs. Developing reliable computational methods for predicting PPI site as screening tools contributes to reduce lots of time and expensive costs for conventional experiments, but how to improve the accuracy is still challenging. We propose a PPI site predictor, called Augmented Graph Attention Network Protein-Protein Interacting Site (AGAT-PPIS), based on AGAT with initial residual and identity mapping, in which eight AGAT layers are connected to mine node embedding representation deeply. AGAT is our augmented version of graph attention network, with added edge features. Besides, extra node features and edge features are introduced to provide more structural information and increase the translation and rotation invariance of the model. On the benchmark test set, AGAT-PPIS significantly surpasses the state-of-the-art method by 8% in Accuracy, 17.1% in Precision, 11.8% in F1-score, 15.1% in Matthews Correlation Coefficient (MCC), 8.1% in Area Under the Receiver Operating Characteristic curve (AUROC), 14.5% in Area Under the Precision-Recall curve (AUPRC), respectively.<\/jats:p>","DOI":"10.1093\/bib\/bbad122","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T13:32:59Z","timestamp":1680615179000},"source":"Crossref","is-referenced-by-count":44,"title":["AGAT-PPIS: a novel protein\u2013protein interaction site predictor based on augmented graph attention network with initial residual and identity mapping"],"prefix":"10.1093","volume":"24","author":[{"given":"Yuting","family":"Zhou","sequence":"first","affiliation":[{"name":"Southwest Jiaotong University School of Computing and Artificial Intelligence, , Chengdu, China"}]},{"given":"Yongquan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Southwest Jiaotong University School of Computing and Artificial Intelligence, , Chengdu, China"},{"name":"Ministry of Education Engineering Research Center of Sustainable Urban Intelligent Transportation, , China"},{"name":"Southwest Jiaotong University Artificial Intelligence Research Institute, , Chengdu, China"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Southwest Jiaotong University School of Computing and Artificial Intelligence, , Chengdu, China"},{"name":"Ministry of Education Engineering Research Center of Sustainable Urban Intelligent Transportation, , China"},{"name":"Southwest Jiaotong University Artificial Intelligence Research Institute, , Chengdu, 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