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The integration of accumulative data from clinical and biomedical research will allow for the excavation of pathological proteins and related interactors. It is also important to systematically study their interacting proteins in order to find more related proteins and potential therapeutic targets. Understanding binding regions in protein interactions will help functional proteomics and provide an alternative method for predicting novel interactions. This study integrated data from biomedical research to achieve systematic mining and analysis of pathogenic proteins and their interaction network.<\/jats:p>\n               <jats:p>A workflow has been built as a solution for the collective information of proteins involved in NDs, related protein\u2013protein interactions (PPIs) and interactive visualizations. It also included protein isoforms and mapped them in a disease-related PPI network to illuminate the impact of alternative splicing on protein binding. The interacting proteins enriched by diseases and biological processes (BPs) revealed possible regulatory modules. A high-resolution network with structural affinity information was generated. Finally, Neurodegenerative Disease Atlas (NDAtlas) was constructed with an interactive and intuitive view of protein docking with 3D molecular graphics beyond the traditional 2D network. NDAtlas is available at http:\/\/bis.zju.edu.cn\/ndatlas.<\/jats:p>","DOI":"10.1093\/bib\/bbad237","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T22:10:34Z","timestamp":1687644634000},"source":"Crossref","is-referenced-by-count":4,"title":["Network integration and protein structural binding analysis of neurodegeneration-related interactome"],"prefix":"10.1093","volume":"24","author":[{"given":"Hongjun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Bioinformatics , College of Life Sciences, , Hangzhou 310058 , China"},{"name":"Zhejiang University , College of Life Sciences, , Hangzhou 310058 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-0059","authenticated-orcid":false,"given":"Yekai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Computer Science, The University of Hong Kong , Hong Kong 999077 , 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