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The two categories of drugs (i.e. chemical drugs and biotech drugs) differ remarkably in molecular properties, action mechanisms, etc. Biotech drugs are up-to-comers but highly promising in modern medicine due to higher specificity and fewer side effects. However, existing DDI prediction methods only consider chemical drugs of small molecules, not biotech drugs of large molecules. Here, we build a large-scale dual-modal graph database named CB-DB and customize a graph-based framework named CB-TIP to reason event-aware DDIs for both chemical and biotech drugs. CB-DB comprehensively integrates various interaction events and two heterogeneous kinds of molecular structures. It imports endogenous proteins founded on the fact that most drugs take effects by interacting with endogenous proteins. In the modality of molecular structure, drugs and endogenous proteins are two heterogeneous kinds of graphs, while in the modality of interaction, they are nodes connected by events (i.e. edges of different relationships). CB-TIP employs graph representation learning methods to generate drug representations from either modality and then contrastively mixes them to predict how likely an event occurs when a drug meets another in an end-to-end manner. Experiments demonstrate CB-TIP\u2019s great superiority in DDI prediction and the promising potential of uncovering novel DDIs.<\/jats:p>","DOI":"10.1093\/bib\/bbad271","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T23:36:27Z","timestamp":1690587387000},"source":"Crossref","is-referenced-by-count":7,"title":["A dual-modal graph learning framework for identifying interaction events among chemical and biotech drugs"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-1489","authenticated-orcid":false,"given":"Zhongying","family":"Ru","sequence":"first","affiliation":[{"name":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"},{"name":"Polytechnic Institute, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"}]},{"given":"Yangyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"}]},{"given":"Jinning","family":"Shao","sequence":"additional","affiliation":[{"name":"Institute of Drug Metabolism and Pharmaceutical Analysis , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"},{"name":"Zhejiang University , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"}]},{"given":"Jianwei","family":"Yin","sequence":"additional","affiliation":[{"name":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"},{"name":"College of Computer Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"}]},{"given":"Linghui","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Drug Metabolism and Pharmaceutical Analysis , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"},{"name":"Zhejiang University , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-1539","authenticated-orcid":false,"given":"Xiaoye","family":"Miao","sequence":"additional","affiliation":[{"name":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. 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