{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:22:54Z","timestamp":1773444174025,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB31000000"],"award-info":[{"award-number":["XDB31000000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB38030300"],"award-info":[{"award-number":["XDB38030300"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Informatization Plan of Chinese Academy of Sciences","award":["CAS-WX2021SF-0101"],"award-info":[{"award-number":["CAS-WX2021SF-0101"]}]},{"name":"Informatization Plan of Chinese Academy of Sciences","award":["CAS-WX2021SF-0111"],"award-info":[{"award-number":["CAS-WX2021SF-0111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Drug\u2013drug interaction (DDI) prediction can discover potential risks of drug combinations in advance by detecting drug pairs that are likely to interact with each other, sparking an increasing demand for computational methods of DDI prediction. However, existing computational DDI methods mostly rely on the single-view paradigm, failing to handle the complex features and intricate patterns of DDIs due to the limited expressiveness of the single view. To this end, we propose a Hierarchical Triple-view Contrastive Learning framework for Drug\u2013Drug Interaction prediction (HTCL-DDI), leveraging the molecular, structural and semantic views to model the complicated information involved in DDI prediction. To aggregate the intra-molecular compositional and structural information, we present a dual attention-aware network in the molecular view. Based on the molecular view, to further capture inter-molecular information, we utilize the one-hop neighboring information and high-order semantic relations in the structural view and semantic view, respectively. Then, we introduce contrastive learning to enhance drug representation learning from multifaceted aspects and improve the robustness of HTCL-DDI. Finally, we conduct extensive experiments on three real-world datasets. All the experimental results show the significant improvement of HTCL-DDI over the state-of-the-art methods, which also demonstrates that HTCL-DDI opens new avenues for ensuring medication safety and identifying synergistic drug combinations.<\/jats:p>","DOI":"10.1093\/bib\/bbad324","type":"journal-article","created":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T03:49:22Z","timestamp":1695527362000},"source":"Crossref","is-referenced-by-count":37,"title":["HTCL-DDI: a hierarchical triple-view contrastive learning framework for drug\u2013drug interaction prediction"],"prefix":"10.1093","volume":"24","author":[{"given":"Ran","family":"Zhang","sequence":"first","affiliation":[{"name":"Computer Network Information Center, Chinese Academy of Sciences , Beijing, 100083 , China"},{"name":"University of Chinese Academy of Sciences , Beijing, 100049 , China"}]},{"given":"Xuezhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Computer Network Information Center, Chinese 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