{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:09:08Z","timestamp":1783476548205,"version":"3.55.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young Elite Scientist Sponsorship Program","award":["BYESS2023026"],"award-info":[{"award-number":["BYESS2023026"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["6220071694"],"award-info":[{"award-number":["6220071694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Artificial intelligence (AI) approaches in cancer analysis typically utilize a \u2018one-size-fits-all\u2019 methodology characterizing average patient responses. This manner neglects the diverse conditions in the pancancer and cancer subtypes of individual patients, resulting in suboptimal outcomes in diagnosis and treatment. To overcome this limitation, we shift from a blanket application of statistics to a focus on the explicit recognition of patient-specific abnormalities. Our objective is to use multiomics data to empower clinicians with personalized molecular descriptions that allow for customized diagnosis and interventions. Here, we propose a highly trustworthy multiomics learning (HTML) framework that employs multiomics self-adaptive dynamic learning to process each sample with data-dependent architectures and computational flows, ensuring personalized and trustworthy patient-centering of cancer diagnosis and prognosis. Extensive testing on a 33-type pancancer dataset and 12 cancer subtype datasets underscored the superior performance of HTML compared with static-architecture-based methods. Our findings also highlighting the potential of HTML in elucidating complex biological pathogenesis and paving the way for improved patient-specific care in cancer treatment.<\/jats:p>","DOI":"10.1093\/bib\/bbad378","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T13:16:50Z","timestamp":1698412610000},"source":"Crossref","is-referenced-by-count":24,"title":["Multiomics dynamic learning enables personalized diagnosis and prognosis for pancancer and cancer subtypes"],"prefix":"10.1093","volume":"24","author":[{"given":"Yuxing","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Big Data and Biomedical AI , College of Future Technology, , Beijing , China"},{"name":"Peking University , College of Future Technology, , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Big Data and Biomedical AI , College of Future 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