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While many studies have engaged in modeling complex drug\u2013disease associations, they often overlook the relevance between different node embeddings. Consequently, we propose a novel weighted local information augmented graph neural network model, termed DRAGNN, for drug repositioning. Specifically, DRAGNN firstly incorporates a graph attention mechanism to dynamically allocate attention coefficients to drug and disease heterogeneous nodes, enhancing the effectiveness of target node information collection. To prevent excessive embedding of information in a limited vector space, we omit self-node information aggregation, thereby emphasizing valuable heterogeneous and homogeneous information. Additionally, average pooling in neighbor information aggregation is introduced to enhance local information while maintaining simplicity. A multi-layer perceptron is then employed to generate the final association predictions. The model\u2019s effectiveness for drug repositioning is supported by a 10-times 10-fold cross-validation on three benchmark datasets. Further validation is provided through analysis of the predicted associations using multiple authoritative data sources, molecular docking experiments and drug\u2013disease network analysis, laying a solid foundation for future drug discovery.<\/jats:p>","DOI":"10.1093\/bib\/bbad431","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T17:42:25Z","timestamp":1701279745000},"source":"Crossref","is-referenced-by-count":104,"title":["Drug repositioning based on weighted local information augmented graph neural network"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-1158","authenticated-orcid":false,"given":"Yajie","family":"Meng","sequence":"first","affiliation":[{"name":"Center of Applied Mathematics & Interdisciplinary Science, School of Mathematical & Physical Sciences, Wuhan Textile University , No. 1, Yangguang Avenue, Jiangxia District, Wuhan City, Hubei Province 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Applied Mathematics & Interdisciplinary Science, School of Mathematical & Physical Sciences, Wuhan Textile University , No. 1, Yangguang Avenue, Jiangxia District, Wuhan City, Hubei Province 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-9130","authenticated-orcid":false,"given":"Junlin","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University , Lushan Road (S), Yuelu District, Changsha, Hunan Province 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-8463","authenticated-orcid":false,"given":"Changcheng","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University , Lushan Road (S), Yuelu District, Changsha, Hunan Province 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfang","family":"Tang","sequence":"additional","affiliation":[{"name":"Center of Applied Mathematics & Interdisciplinary Science, School of Mathematical & Physical Sciences, Wuhan Textile University , No. 1, Yangguang Avenue, Jiangxia District, Wuhan City, Hubei Province 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[{"name":"Center of Applied Mathematics & Interdisciplinary Science, School of Mathematical & Physical Sciences, Wuhan Textile University , No. 1, Yangguang Avenue, Jiangxia District, Wuhan City, Hubei Province 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Applied Mathematics & Interdisciplinary Science, School of 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