{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:46:19Z","timestamp":1776469579280,"version":"3.51.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Here, we will provide our insights into the usage of PharmCAT as part of a pharmacogenetic clinical decision support pipeline, which addresses the challenges in mapping clinical dosing guidelines to variants to be extracted from genetic datasets. After a general outline of pharmacogenetics, we describe some features of PharmCAT and how we integrated it into a pharmacogenetic clinical decision support system within a clinical information system. We conclude with promising developments regarding future PharmCAT releases.<\/jats:p>","DOI":"10.1093\/bib\/bbad452","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T05:31:31Z","timestamp":1701927091000},"source":"Crossref","is-referenced-by-count":4,"title":["Using the PharmCAT tool for Pharmacogenetic clinical decision support"],"prefix":"10.1093","volume":"25","author":[{"given":"Kevin","family":"Tippenhauer","sequence":"first","affiliation":[{"name":"Bern University of Applied Sciences , Quellgasse 21, 2500 Biel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwin","family":"Philips","sequence":"additional","affiliation":[{"name":"Bern University of Applied Sciences , Quellgasse 21, 2500 Biel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Largiad\u00e8r","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry at the Bern University Hospital , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-2860","authenticated-orcid":false,"given":"Murat","family":"Sariyar","sequence":"additional","affiliation":[{"name":"Bern University of Applied Sciences , Quellgasse 21, 2500 Biel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"issue":"9242","key":"2023120618565927900_ref1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S0140-6736(00)03167-6","article-title":"Pharmacogenetics and adverse drug reactions","volume":"356","author":"Meyer","year":"2000","journal-title":"Lancet"},{"issue":"2","key":"2023120618565927900_ref2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/cpt.350","article-title":"Genetic variation among 82 pharmacogenes: the PGRNseq data from the eMERGE network","volume":"100","author":"Bush","year":"2016","journal-title":"Clin Pharmacol Ther"},{"key":"2023120618565927900_ref3","author":"CPIC Guidelines"},{"issue":"3","key":"2023120618565927900_ref4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/clpt.2010.320","article-title":"Clinical Pharmacogenetics Implementation Consortium Guidelines for thiopurine methyltransferase genotype and thiopurine dosing","volume":"89","author":"Relling","year":"2011","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"2023120618565927900_ref5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/cpt.928","article-title":"PharmCAT: a pharmacogenomics clinical annotation tool","volume":"104","author":"Klein","year":"2018","journal-title":"Clin Pharmacol Ther"},{"issue":"10","key":"2023120618565927900_ref6","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.ajhg.2023.09.001","article-title":"Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank","volume":"110","author":"Li","year":"2023","journal-title":"Am J Hum Genet"},{"issue":"270","key":"2023120618565927900_ref7","first-page":"618","article-title":"Integrating pharmacogenetic decision support into a clinical information system","volume":"16","author":"Tippenhauer","year":"2020","journal-title":"Stud Health Technol Inform"},{"issue":"5","key":"2023120618565927900_ref8","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/cpt.2790","article-title":"How to run the pharmacogenomics clinical annotation tool (PharmCAT)","volume":"113","author":"Li","year":"2023","journal-title":"Clin Pharmacol Ther"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/1\/bbad452\/54017292\/bbad452.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/1\/bbad452\/54017292\/bbad452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T05:31:36Z","timestamp":1701927096000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbad452\/7458913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,11,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbad452","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,11,22]]},"article-number":"bbad452"}}