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Recently, much attention has been attracted to network representation learning to learn rich information from heterogeneous data. Although network representation learning algorithms have achieved success in predicting DTI, several manually designed meta-graphs limit the capability of extracting complex semantic information. To address the problem, we introduce an adaptive meta-graph-based method, termed AMGDTI, for DTI prediction. In the proposed AMGDTI, the semantic information is automatically aggregated from a heterogeneous network by training an adaptive meta-graph, thereby achieving efficient information integration without requiring domain knowledge. The effectiveness of the proposed AMGDTI is verified on two benchmark datasets. Experimental results demonstrate that the AMGDTI method overall outperforms eight state-of-the-art methods in predicting DTI and achieves the accurate identification of novel DTIs. It is also verified that the adaptive meta-graph exhibits flexibility and effectively captures complex fine-grained semantic information, enabling the learning of intricate heterogeneous network topology and the inference of potential drug\u2013target relationship.<\/jats:p>","DOI":"10.1093\/bib\/bbad474","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T02:16:34Z","timestamp":1703556994000},"source":"Crossref","is-referenced-by-count":18,"title":["AMGDTI: drug\u2013target interaction prediction based on adaptive meta-graph learning in heterogeneous network"],"prefix":"10.1093","volume":"25","author":[{"given":"Yansen","family":"Su","sequence":"first","affiliation":[{"name":"Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University , Hefei, 230601 , China"}]},{"given":"Zhiyang","family":"Hu","sequence":"additional","affiliation":[{"name":"Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University , Hefei, 230601 , China"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University , Hefei, 230601 , China"}]},{"given":"Yannan","family":"Bin","sequence":"additional","affiliation":[{"name":"Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University , Hefei, 230601 , China"}]},{"given":"Chunhou","family":"Zheng","sequence":"additional","affiliation":[{"name":"Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University , Hefei, 230601 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1137-5487","authenticated-orcid":false,"given":"Haitao","family":"Li","sequence":"additional","affiliation":[{"name":"Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University , Hefei, 230601 , China"}]},{"given":"Haowen","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University , Hunan, 410082 , China"}]},{"given":"Xiangxiang","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University , Hunan, 410082 , China"}]}],"member":"286","published-online":{"date-parts":[[2023,12,25]]},"reference":[{"issue":"5","key":"2023122602162128000_ref1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/bib\/bbt056","article-title":"Similarity-based machine learning methods for predicting drug\u2013target interactions: a brief review","volume":"15","author":"Ding","year":"2014","journal-title":"Brief Bioinform"},{"issue":"3","key":"2023122602162128000_ref2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd3078","article-title":"How to improve r&d productivity: the pharmaceutical industry\u2019s grand 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