{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:10:49Z","timestamp":1778782249648,"version":"3.51.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370711"],"award-info":[{"award-number":["32370711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300554"],"award-info":[{"award-number":["32300554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220530152409020"],"award-info":[{"award-number":["JCYJ20220530152409020"]}]},{"name":"Shenzhen Medical Research Fund","award":["A2303033"],"award-info":[{"award-number":["A2303033"]}]},{"name":"Clinical Research Center for General Surgery of Gansu Province","award":["20JR10FA661"],"award-info":[{"award-number":["20JR10FA661"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Portal vein thrombosis (PVT) is a significant issue in cirrhotic patients, necessitating early detection. This study aims to develop a data-driven predictive model for PVT diagnosis in chronic hepatitis liver cirrhosis patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We employed data from a total of 816 chronic cirrhosis patients with PVT, divided into the Lanzhou cohort (n\u2009=\u2009468) for training and the Jilin cohort (n\u2009=\u2009348) for validation. This dataset encompassed a wide range of variables, including general characteristics, blood parameters, ultrasonography findings and cirrhosis grading. To build our predictive model, we employed a sophisticated stacking approach, which included Support Vector Machine (SVM), Na\u00efve Bayes and Quadratic Discriminant Analysis (QDA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the Lanzhou cohort, SVM and Na\u00efve Bayes classifiers effectively classified PVT cases from non-PVT cases, among the top features of which seven were shared: Portal Velocity (PV), Prothrombin Time (PT), Portal Vein Diameter (PVD), Prothrombin Time Activity (PTA), Activated Partial Thromboplastin Time (APTT), age and Child\u2013Pugh score (CPS). The QDA model, trained based on the seven shared features on the Lanzhou cohort and validated on the Jilin cohort, demonstrated significant differentiation between PVT and non-PVT cases (AUROC\u2009=\u20090.73 and AUROC\u2009=\u20090.86, respectively). Subsequently, comparative analysis showed that our QDA model outperformed several other machine learning methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study presents a comprehensive data-driven model for PVT diagnosis in cirrhotic patients, enhancing clinical decision-making. The SVM\u2013Na\u00efve Bayes\u2013QDA model offers a precise approach to managing PVT in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bib\/bbad478","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T08:32:53Z","timestamp":1705307573000},"source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Prediction of portal vein thrombosis in chronic cirrhosis patients using data-driven precision medicine model"],"prefix":"10.1093","volume":"25","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"The First Hospital of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden"},{"name":"Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden"},{"name":"Heart and Lung Centre, Department of Pulmonary Medicine , University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"The First School of Clinical Medicine , Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xubin","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Computing and Information Technology , Great Bay University, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guole","family":"Nie","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jican","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Computing and Information Technology , Great Bay University, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"He","sequence":"additional","affiliation":[{"name":"Jilin Hepato-Biliary Diseases Hospital , Changchun , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Wheelock","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden"},{"name":"Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden"},{"name":"Department of Respiratory Medicine and Allergy, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden"},{"name":"Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shenzhen People's Hospital , The First Affiliated Hospital of Southern University of Science and Technology, , Shenzhen , China"},{"name":"The Second Clinical Medical College of Jinan University , The First Affiliated Hospital of Southern University of Science and Technology, , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University , Lanzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,13]]},"reference":[{"key":"2024052406072408500_ref1","article-title":"Consensus for management of portal vein thrombosis in liver cirrhosis (2020, Shanghai)","volume":"28","author":"Hepatobiliary Disease Study Group, Chinese Society of Gastroenterology, Chinese Medical Association","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"3","key":"2024052406072408500_ref2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-2036.2009.04182.x","article-title":"Systematic review: Portal Vein Thrombosis in cirrhosis","volume":"31","author":"Tsochatzis","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"issue":"27","key":"2024052406072408500_ref3","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.4254\/wjh.v7.i27.2774","article-title":"Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis","volume":"7","author":"Stine","year":"2015","journal-title":"World J Hepatol"},{"issue":"6","key":"2024052406072408500_ref4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.clinre.2015.02.012","article-title":"Association between Portal Vein Thrombosis and risk of bleeding in liver cirrhosis: A systematic review of the literature","volume":"39","author":"Xingshun","year":"2015","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"1","key":"2024052406072408500_ref5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/liv.13500","article-title":"Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case-control study[J]","volume":"38","author":"Stine","year":"2018","journal-title":"Liver Int"},{"issue":"6","key":"2024052406072408500_ref6","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.jhep.2021.07.020","article-title":"Predicting portal thrombosis in cirrhosis: A prospective study of clinical, ultrasonographic and hemostatic factors","volume":"75","author":"Turon","year":"2021","journal-title":"J Hepatol"},{"issue":"2","key":"2024052406072408500_ref7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.dld.2016.11.013","article-title":"Portal vein thrombosis: The role of imaging in the clinical setting","volume":"49","author":"Margini","year":"2017","journal-title":"Dig Liver Dis"},{"issue":"1","key":"2024052406072408500_ref8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2214\/AJR.18.19548","article-title":"Portal vein thrombosis: Imaging the spectrum of disease with an emphasis on MRI features","volume":"211","author":"Jha","year":"2018","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"2024052406072408500_ref9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00261-007-9200-x","article-title":"Portal vein thrombosis: CT features","volume":"33","author":"Lee","year":"2008","journal-title":"Abdom Imaging"},{"issue":"2","key":"2024052406072408500_ref10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/a-1642-0990","article-title":"Portal vein thrombosis: Diagnosis and endovascular management","volume":"194","author":"Connie","year":"2022","journal-title":"Rofo"},{"issue":"1","key":"2024052406072408500_ref11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/07853890.2022.2028893","article-title":"A practical nomogram based on systemic inflammatory markers for predicting portal vein thrombosis in patients with liver cirrhosis","volume":"54","author":"Xing","year":"2022","journal-title":"Ann Med"},{"key":"2024052406072408500_ref12","doi-asserted-by":"crossref","first-page":"9583706","DOI":"10.1155\/2020\/9583706","article-title":"Risk factors of portal vein thrombosis after devascularization treatment in patients with liver cirrhosis: A nested case-control study","volume":"2020","author":"Lu","year":"2020","journal-title":"Biomed Res Int"},{"key":"2024052406072408500_ref13","article-title":"Long non-coding RNA pairs to assist in diagnosing sepsis","volume":"22","author":"Zheng","journal-title":"BMC Genomics"},{"key":"2024052406072408500_ref14","article-title":"Improving bulk RNA-seq classification by transferring genesignature from single cells in acute myeloid leukemia","volume":"23","author":"Wang","journal-title":"Brief Bioinform"},{"key":"2024052406072408500_ref15","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad498","article-title":"MrGPS: An m6A-related gene pair signature to predict the prognosis and immunological impact of glioma patients","volume-title":"Brief Bioinform","author":"Zhang"},{"key":"2024052406072408500_ref16","article-title":"GPGPS: A robust prognostic gene pair signature of glioma ensembling IDH mutation and 1p\/19q co-deletion","volume-title":"Bioinformatics","author":"Cheng"},{"issue":"14","key":"2024052406072408500_ref17","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1093\/bioinformatics\/btac379","article-title":"meGPS: A multi-omics signature for hepatocellular carcinoma detection integrating methylome and transcriptome data","volume":"38","author":"Wu","year":"2022","journal-title":"Bioinformatics"},{"key":"2024052406072408500_ref18","article-title":"Whole transcriptome analysis reveals non-coding RNA's competing endogenous gene pairs as novel form of motifs in serous ovarian cancer","volume":"148","author":"Li","journal-title":"Comput Biol Med"},{"issue":"3","key":"2024052406072408500_ref19","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1002\/ctm2.123","article-title":"A long non-coding RNA signature for diagnostic prediction of sepsis upon ICU admission","volume":"10","author":"Liu","year":"2020","journal-title":"Clin Transl Med"},{"key":"2024052406072408500_ref20","doi-asserted-by":"crossref","DOI":"10.1109\/TCBB.2021.3107874","article-title":"A Robust and Generalizable Immune-Related Signature for Sepsis Diagnostics","volume-title":"IEEE\/ACM Trans Comput Biol Bioinform","author":"Yang"},{"key":"2024052406072408500_ref21","article-title":"bvnGPS: a generalizable diagnostic model for acute bacterial and viral infection using integrative host transcriptomics and pretrained neural networks","volume":"39","author":"Li","journal-title":"Bioinformatics"},{"key":"2024052406072408500_ref22","article-title":"RNA trafficking and subcellular localization-a review of mechanisms, experimental and predictive methodologies","volume":"24","author":"Wang","journal-title":"Brief Bioinform"},{"issue":"11","key":"2024052406072408500_ref23","first-page":"2408","article-title":"Chinese guidelines on the management of liver cirrhosis","volume":"35","author":"Xiaoyuan","year":"2019","journal-title":"J Clin Hepatobiliary Dis"},{"key":"2024052406072408500_ref24","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4302-5990-9_3","article-title":"Support Vector Machines for Classification","volume-title":"Efficient Learning Machines: Theories, Concepts, and Applications for Engineers and System Designers","author":"Awad"},{"key":"2024052406072408500_ref25","volume-title":"Probabilistic Graphical Models: Principles and Applications","author":"Sucar"},{"key":"2024052406072408500_ref26","article-title":"A unified approach to interpreting model predictions","volume-title":"Advances in Neural Information Processing Systems","author":"Lundberg"},{"key":"2024052406072408500_ref27","article-title":"Discriminant Analysis","volume-title":"Multivariate Analysis: An Application-Oriented Introduction","author":"Backhaus"},{"key":"2024052406072408500_ref28","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-9863-7_209","article-title":"Area under the ROC Curve","volume-title":"Encyclopedia of Systems Biology","author":"Melo"},{"issue":"2","key":"2024052406072408500_ref29","doi-asserted-by":"crossref","first-page":"101649","DOI":"10.1016\/j.clinre.2021.101649","article-title":"Efficacy and safety of anticoagulants in liver cirrhosis patients with portal vein thrombosis: A meta-analysis","volume":"45","author":"Gao","year":"2021","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"1","key":"2024052406072408500_ref30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/MEG.0000000000001237","article-title":"A prediction model for successful anticoagulation in cirrhotic portal vein thrombosis","volume":"31","author":"Rodriguez-Castro","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"2024052406072408500_ref31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3748\/wjg.v16.i2.143","article-title":"Portal vein thrombosis: Insight into physiopathology, diagnosis, and treatment","volume":"16","author":"Ponziani","year":"2010","journal-title":"World J Gastroenterol"},{"key":"2024052406072408500_ref32","article-title":"The effect of splenic vein diameter on the diagnosis of portal vein thrombosis","volume":"50","author":"Xiong","journal-title":"Med Phys"},{"issue":"4","key":"2024052406072408500_ref33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.21037\/atm-20-4912","article-title":"Increased portal vein diameter is predictive of portal vein thrombosis development in patients with liver cirrhosis","volume":"9","author":"Gang","year":"2021","journal-title":"Ann Transl Med"},{"issue":"9","key":"2024052406072408500_ref34","first-page":"1265","article-title":"Construction and validation of a nomogram for predicting the risk of portal vein thrombosis after splenectomy in patients with hepatitis B cirrhosis","volume":"40","author":"Xu","year":"2020","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"5","key":"2024052406072408500_ref35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/MEG.0000000000000325","article-title":"De-novo portal vein thrombosis in liver cirrhosis: Risk factors and correlation with the model for end-stage liver disease scoring system","volume":"27","author":"Abdel-Razik","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"2024052406072408500_ref36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1055\/s-0040-1715473","article-title":"New insights into the pathogenesis, risk factors, and treatment of portal vein thrombosis in patients with cirrhosis","volume":"46","author":"Nicoar\u0103-Farc\u0103u","year":"2020","journal-title":"Semin Thromb Hemost"},{"issue":"22","key":"2024052406072408500_ref37","doi-asserted-by":"crossref","first-page":"6769","DOI":"10.3748\/wjg.v21.i22.6769","article-title":"Portal vein thrombosis in cirrhosis: Controversies and latest developments","volume":"21","author":"Harding","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"2","key":"2024052406072408500_ref38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jhep.2013.03.036","article-title":"Evidence that low protein C contributes to the procoagulant imbalance in cirrhosis","volume":"59","author":"Tripodi","year":"2013","journal-title":"J Hepatol"},{"issue":"11","key":"2024052406072408500_ref39","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5500\/wjt.v10.i11.345","article-title":"Intraoperative thromboelastography as a tool to predict postoperative thrombosis during liver transplantation","volume":"10","author":"Pietri","year":"2020","journal-title":"World J Transplant"},{"issue":"12","key":"2024052406072408500_ref40","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/lt.25630","article-title":"Development of a model to predict portal vein thrombosis in liver transplant candidates: the portal vein thrombosis risk index","volume":"25","author":"Gaballa","year":"2019","journal-title":"Liver Transpl"},{"issue":"3","key":"2024052406072408500_ref41","first-page":"288","article-title":"Analysis of risk factors for portal vein thrombosis in 591 patients with liver cirrhosis","volume":"44","author":"Ling","year":"2017","journal-title":"Fudan Univ J Med Sci"},{"issue":"8","key":"2024052406072408500_ref42","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s11739-016-1416-8","article-title":"Portal vein thrombosis relevance on liver cirrhosis: Italian venous thrombotic events registry","volume":"11","author":"Violi","year":"2016","journal-title":"Intern Emerg Med"},{"issue":"5","key":"2024052406072408500_ref43","first-page":"407","article-title":"Analysis of risk factors and prognosis of portal vein thrombosis in cirrhosis","volume":"5","author":"Chaiming","year":"2019","journal-title":"J Vasc Endovasc Surg"},{"issue":"4","key":"2024052406072408500_ref44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.23736\/S0392-9590.17.03820-2","article-title":"Interrelationship between venous and arterial thrombosis","volume":"36","author":"Poredo\u0161","year":"2017","journal-title":"Int Angiol"},{"issue":"11","key":"2024052406072408500_ref45","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.dld.2015.06.003","article-title":"Portal vein aneurysm: What to know","volume":"47","author":"Laurenzi","year":"2015","journal-title":"Dig Liver Dis"},{"issue":"6","key":"2024052406072408500_ref46","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/bjs.7002","article-title":"Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension","volume":"97","author":"Kinjo","year":"2010","journal-title":"Br J Surg"},{"issue":"5","key":"2024052406072408500_ref47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.surg.2008.06.030","article-title":"Diameter of splenic vein is a risk factor for portal or splenic vein thrombosis after laparoscopic splenectomy","volume":"145","author":"Danno","year":"2009","journal-title":"Surgery"},{"issue":"5","key":"2024052406072408500_ref48","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/jamainternmed.2015.90","article-title":"Should the term coagulopathy in cirrhosis be abandoned?","volume":"175","author":"Violi","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"9","key":"2024052406072408500_ref49","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.306853","article-title":"Cross talk pathways between coagulation and inflammation","volume":"118","author":"Foley","year":"2016","journal-title":"Circ Res"},{"issue":"4","key":"2024052406072408500_ref50","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/s-0033-1334144","article-title":"Clotting activation and hyperfibrinolysis in cirrhosis: Implication for bleeding and thrombosis","volume":"39","author":"Violi","year":"2013","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"2024052406072408500_ref51","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0046-8177(98)90071-5","article-title":"Alterations in colonic mucosal vessels in patients with cirrhosis and noncirrhotic portal hypertension","volume":"29","author":"Lamps","year":"1998","journal-title":"Hum Pathol"},{"issue":"3","key":"2024052406072408500_ref52","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MEG.0000000000001526","article-title":"Systemic inflammation and portal vein thrombosis in cirrhotic patients with gastroesophageal varices","volume":"32","author":"Huang","year":"2020","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024052406072408500_ref53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2147\/CEG.S172663","article-title":"D-dimer plasmatic levels as a marker for diagnosis and prognosis of hepatocellular carcinoma patients with portal vein thrombosis","volume":"11","author":"Malaguarnera","year":"2018","journal-title":"Clin Exp Gastroenterol"},{"issue":"1","key":"2024052406072408500_ref54","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11239-016-1401-0","article-title":"Increased soluble GPVI levels in cirrhosis: Evidence for early in vivo platelet activation","volume":"43","author":"Egan","year":"2017","journal-title":"J Thromb Thrombolysis"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/1\/bbad478\/57789082\/bbad478.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/1\/bbad478\/57789082\/bbad478.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T07:39:03Z","timestamp":1716536343000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbad478\/7529151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,11,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbad478","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,11,22]]},"article-number":"bbad478"}}