{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:16:10Z","timestamp":1765178170970,"version":"build-2065373602"},"reference-count":105,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research Funds for the Central-level Scientific Research Institute","award":["2019XK320078","BJ-2019-092"],"award-info":[{"award-number":["2019XK320078","BJ-2019-092"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["BJ-2022-155"],"award-info":[{"award-number":["BJ-2022-155"]}]},{"name":"National Research Council of Thailand and Mahidol University","award":["N42A660380"],"award-info":[{"award-number":["N42A660380"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not have the potential to encode proteins. Meanwhile, they can occupy a significant portion of the human genome and participate in gene expression regulation through various mechanisms. Gestational diabetes mellitus (GDM) is a pathologic condition of carbohydrate intolerance that begins or is first detected during pregnancy, making it one of the most common pregnancy complications. Although the exact pathogenesis of GDM remains unclear, several recent studies have shown that ncRNAs play a crucial regulatory role in GDM. Herein, we present a comprehensive review on the multiple mechanisms of ncRNAs in GDM along with their potential role as biomarkers. In addition, we investigate the contribution of deep learning-based models in discovering disease-specific ncRNA biomarkers and elucidate the underlying mechanisms of ncRNA. This might assist community-wide efforts to obtain insights into the regulatory mechanisms of ncRNAs in disease and guide a novel approach for early diagnosis and treatment of disease.<\/jats:p>","DOI":"10.1093\/bib\/bbad489","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T11:46:15Z","timestamp":1704714375000},"source":"Crossref","is-referenced-by-count":9,"title":["The role of ncRNA regulatory mechanisms in diseases\u2014case on gestational diabetes"],"prefix":"10.1093","volume":"25","author":[{"given":"Dong","family":"Gao","sequence":"first","affiliation":[{"name":"School of Life Science and Technology , Center for Informational Biology, , Chengdu 610054 , China"},{"name":"University of Electronic Science and Technology of China , Center for Informational Biology, , Chengdu 610054 , China"}]},{"given":"Liping","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Healthcare Technology, Chengdu Neusoft University , Chengdu 611844 , China"}]},{"given":"Yu-Duo","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology , Center for Informational Biology, , Chengdu 610054 , China"},{"name":"University of Electronic Science and Technology of China , Center for Informational Biology, , Chengdu 610054 , China"}]},{"given":"Nalini","family":"Schaduangrat","sequence":"additional","affiliation":[{"name":"Center for Research Innovation and Biomedical Informatics , Faculty of Medical Technology, , Bangkok 10700 , Thailand"},{"name":"Mahidol University , Faculty of Medical Technology, , Bangkok 10700 , Thailand"}]},{"given":"Xiao-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology , Center for Informational Biology, , Chengdu 610054 , China"},{"name":"University of Electronic Science and Technology of China , Center for Informational Biology, , Chengdu 610054 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3068-8849","authenticated-orcid":false,"given":"Shi-Shi","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology , Center for Informational Biology, , Chengdu 610054 , China"},{"name":"University of Electronic Science and Technology of China , Center for Informational Biology, , Chengdu 610054 , China"}]},{"given":"Yu-He","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology , Center for Informational Biology, , Chengdu 610054 , China"},{"name":"University of Electronic Science and Technology of China , Center for Informational Biology, , Chengdu 610054 , China"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine , Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, , Beijing 100730 , China"},{"name":"Chinese Academy of Medical Sciences , Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, , Beijing 100730 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-8709","authenticated-orcid":false,"given":"Watshara","family":"Shoombuatong","sequence":"additional","affiliation":[{"name":"Center for Research Innovation and Biomedical Informatics , Faculty of Medical Technology, , Bangkok 10700 , Thailand"},{"name":"Mahidol University , Faculty of Medical Technology, , Bangkok 10700 , Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-9571","authenticated-orcid":false,"given":"Hui","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology , Center for Informational Biology, , Chengdu 610054 , China"},{"name":"University of Electronic Science and Technology of China , Center for Informational Biology, , Chengdu 610054 , China"}]}],"member":"286","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"2024012514013344700_ref1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1248\/yakushi.20-00002","article-title":"Non-coding natural antisense RNA: mechanisms of action in the regulation of target gene expression and its clinical implications","volume":"140","author":"Kimura","year":"2020","journal-title":"Yakugaku Zasshi"},{"issue":"7","key":"2024012514013344700_ref2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3390\/genes14071429","article-title":"Non-coding RNAs in human health and diseases","volume":"14","author":"Good","year":"2023","journal-title":"Genes"},{"key":"2024012514013344700_ref3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCULATIONAHA.119.042474","article-title":"Regulatory RNAs in heart failure","volume":"141","author":"Gomes","year":"2020","journal-title":"Circulation"},{"key":"2024012514013344700_ref4","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1093\/eurheartj\/ehac463","article-title":"Small non-coding RNA therapeutics for cardiovascular disease","volume":"43","author":"Shah","year":"2022","journal-title":"Eur Heart J"},{"issue":"1","key":"2024012514013344700_ref5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","article-title":"Gestational diabetes mellitus","volume":"5","author":"McIntyre","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2024012514013344700_ref6","first-page":"1","article-title":"MiRNAs in gestational diabetes mellitus: potential mechanisms and clinical applications","volume":"2021","author":"Liu","year":"2021","journal-title":"J Diabetes Res"},{"issue":"19","key":"2024012514013344700_ref7","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"Group HSCR","year":"2008","journal-title":"N Engl J Med"},{"key":"2024012514013344700_ref8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.18502\/ijrm.v19i9.9715","article-title":"Gestational diabetes mellitus: major risk factors and pregnancy-related outcomes: a cohort study","volume":"19","author":"Kouhkan","year":"2021","journal-title":"Int J Reprod Biomed"},{"key":"2024012514013344700_ref9","article-title":"Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis","volume":"369","author":"Vounzoulaki","year":"2020","journal-title":"BMJ"},{"key":"2024012514013344700_ref10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.diabres.2019.03.030","article-title":"High risk of metabolic syndrome after delivery in pregnancies complicated by gestational diabetes","volume":"150","author":"Shen","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"2024012514013344700_ref11","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1001\/jama.2018.11628","article-title":"Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity","volume":"320","author":"Lowe","year":"2018","journal-title":"JAMA"},{"key":"2024012514013344700_ref12","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.2337\/dc07-s206","article-title":"Increasing prevalence of gestational diabetes mellitus","volume":"30","author":"Ferrara","year":"2007","journal-title":"Diabetes Care"},{"key":"2024012514013344700_ref13","doi-asserted-by":"crossref","first-page":"526","DOI":"10.2337\/dc11-1641","article-title":"Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel\u2013recommended criteria","volume":"35","author":"Sacks","year":"2012","journal-title":"Diabetes Care"},{"key":"2024012514013344700_ref14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jdi.12854","article-title":"Prevalence of gestational diabetes mellitus in mainland China: a systematic review and meta-analysis","volume":"10","author":"Gao","year":"2019","journal-title":"J Diabetes Investig"},{"key":"2024012514013344700_ref15","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"2. Classification and diagnosis of diabetes: standards of care in diabetes\u20142023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"2024012514013344700_ref16","article-title":"Non-coding RNAs in diabetes mellitus and diabetic cardiovascular disease","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024012514013344700_ref17","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.2147\/DMSO.S325993","article-title":"Aberrantly expressed non-coding RNAs in the placenta and their role in the pathophysiology of gestational diabetes mellitus","volume":"14","author":"Du","year":"2021","journal-title":"Diabetes Metab Syndr Obes Targets Ther"},{"key":"2024012514013344700_ref18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40781-018-0183-7","article-title":"Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review","volume":"60","author":"Dhanoa","year":"2018","journal-title":"J Anim Sci Technol"},{"key":"2024012514013344700_ref19","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res"},{"key":"2024012514013344700_ref20","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1093\/nar\/gks296","article-title":"Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs","volume":"40","author":"Moran","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2024012514013344700_ref21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"2024012514013344700_ref22","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","article-title":"Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches","volume":"96","author":"Beermann","year":"2016","journal-title":"Physiol Rev"},{"key":"2024012514013344700_ref23","first-page":"w14703","article-title":"The hypoxic kidney: pathogenesis and noncoding RNA-based therapeutic strategies","volume":"149","author":"Haddad","year":"2019","journal-title":"Swiss Med Wkly"},{"key":"2024012514013344700_ref24","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nsmb.2428","article-title":"Cis-acting noncoding RNAs: friends and foes","volume":"19","author":"Guil","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"2024012514013344700_ref25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","article-title":"Non-coding RNAs: classification, biology and functioning","volume":"937","author":"Hombach","year":"2016","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"2024012514013344700_ref26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/ijms17010078","article-title":"Circulating microRNAs as biomarkers for sepsis","volume":"17","author":"Benz","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2024012514013344700_ref27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of microRNA biogenesis and its crosstalk with other cellular pathways","volume":"20","author":"Treiber","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024012514013344700_ref28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.1090599","article-title":"Nuclear export of MicroRNA precursors","volume":"303","author":"Lund","year":"2004","journal-title":"Science"},{"key":"2024012514013344700_ref29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024012514013344700_ref30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2024012514013344700_ref31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1586\/14737159.2015.1053468","article-title":"miRNAs in pregnancy-related complications","volume":"15","author":"Lycoudi","year":"2015","journal-title":"Expert Rev Mol Diagn"},{"key":"2024012514013344700_ref32","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1242\/dev.02070","article-title":"microPrimer: the biogenesis and function of microRNA","volume":"132","author":"Du","year":"2005","journal-title":"Development"},{"key":"2024012514013344700_ref33","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","article-title":"Circular RNAs: characterization, cellular roles, and applications","volume":"185","author":"Liu","year":"2022","journal-title":"Cell"},{"key":"2024012514013344700_ref34","doi-asserted-by":"crossref","first-page":"e100836","DOI":"10.15252\/embj.2018100836","article-title":"Past, present, and future of circRNAs","volume":"38","author":"Patop","year":"2019","journal-title":"EMBO J"},{"issue":"12","key":"2024012514013344700_ref35","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.3390\/biom11121755","article-title":"Circular RNA-is the circle perfect?","volume":"11","author":"Caba","year":"2021","journal-title":"Biomolecules"},{"key":"2024012514013344700_ref36","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/15353702231160327","article-title":"Circulating lncRNAs NONHSAT054669.2 and ENST00000525337 can be used as early biomarkers of gestational diabetes mellitus","volume":"248","author":"Jiang","year":"2023","journal-title":"Exp Biol Med (Maywood)"},{"key":"2024012514013344700_ref37","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.2147\/IJGM.S341106","article-title":"Long non-coding RNA HOTAIR expression and clinical significance in patients with gestational diabetes","volume":"14","author":"Su","year":"2021","journal-title":"Int J Gen Med"},{"key":"2024012514013344700_ref38","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.2147\/DMSO.S319739","article-title":"LncRNA SOX2OT is upregulated in gestational diabetes mellitus (GDM) and correlated with multiple adverse events","volume":"14","author":"Ran","year":"2021","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2024012514013344700_ref39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2020.107749","article-title":"LncRNA MEG8 is upregulated in gestational diabetes mellitus (GDM) and predicted kidney injury","volume":"35","author":"Zhang","year":"2021","journal-title":"J Diabetes Complications"},{"key":"2024012514013344700_ref40","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2147\/DMSO.S263942","article-title":"lncRNA SNHG17 is downregulated in gestational diabetes mellitus (GDM) and has predictive values","volume":"14","author":"Li","year":"2021","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2024012514013344700_ref41","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/ijms19113342","article-title":"The pathophysiology of gestational diabetes mellitus","volume":"19","author":"Plows","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2024012514013344700_ref42","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/nep.14112","article-title":"Role of lncRNA-MEG8\/miR-296-3p axis in gestational diabetes mellitus","volume":"27","author":"Bian","year":"2022","journal-title":"Nephrology (Carlton)"},{"key":"2024012514013344700_ref43","doi-asserted-by":"crossref","first-page":"13224","DOI":"10.1080\/21655979.2022.2076982","article-title":"Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-5p\/wingless-type MMTV integration site family member 7A axis","volume":"13","author":"Cao","year":"2022","journal-title":"Bioengineered"},{"key":"2024012514013344700_ref44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4093\/dmj.2021.0216","article-title":"Long non-coding RNA TUG1 attenuates insulin resistance in mice with gestational diabetes mellitus via regulation of the MicroRNA-328-3p\/SREBP-2\/ERK Axis","volume":"47","author":"Tang","year":"2023","journal-title":"Diabetes Metab J"},{"key":"2024012514013344700_ref45","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s11596-023-2738-1","article-title":"LncRNA HCG27 promotes glucose uptake ability of HUVECs by MiR-378a-3p\/MAPK1 pathway","volume":"43","author":"Zhang","year":"2023","journal-title":"Curr Med Sci"},{"key":"2024012514013344700_ref46","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1055\/a-2085-6171","article-title":"Study on the regulation of trophoblast activity by abnormally expressed lncRNA CCDC144NL-AS1 in patients with gestational diabetes mellitus","volume":"55","author":"Cao","year":"2023","journal-title":"Horm Metab Res"},{"key":"2024012514013344700_ref47","doi-asserted-by":"crossref","first-page":"716","DOI":"10.21037\/cdt-21-110","article-title":"LncRNA XIST serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell via miR-497-5p\/FOXO1 axis","volume":"11","author":"Li","year":"2021","journal-title":"Cardiovasc Diagn Ther"},{"key":"2024012514013344700_ref48","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s43032-021-00687-z","article-title":"LncRNA-SNX17 promotes HTR-8\/SVneo proliferation and invasion through miR-517a\/IGF-1 in the placenta of diabetic macrosomia","volume":"29","author":"Guiyu","year":"2022","journal-title":"Reprod Sci"},{"key":"2024012514013344700_ref49","doi-asserted-by":"crossref","first-page":"903","DOI":"10.17219\/acem\/121524","article-title":"Expression and function of lncRNA MALAT1 in gestational diabetes mellitus","volume":"29","author":"Zhang","year":"2020","journal-title":"Adv Clin Exp Med"},{"key":"2024012514013344700_ref50","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1159\/000520340","article-title":"LncRNA OIP5-AS1 signatures as a biomarker of gestational diabetes mellitus and a regulator on trophoblast cells","volume":"86","author":"Li","year":"2021","journal-title":"Gynecol Obstet Invest"},{"key":"2024012514013344700_ref51","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.21037\/apm-21-2940","article-title":"LncRNA RPL13p5 gene expression promotes insulin resistance in patients with gestational diabetes","volume":"10","author":"Li","year":"2021","journal-title":"Ann Palliat Med"},{"key":"2024012514013344700_ref52","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1530\/EC-21-0227","article-title":"The association between expression of lncRNAs in patients with GDM","volume":"10","author":"Li","year":"2021","journal-title":"Endocr Connect"},{"key":"2024012514013344700_ref53","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s12884-022-04716-w","article-title":"Biological networks in gestational diabetes mellitus: insights into the mechanism of crosstalk between long non-coding RNA and N(6)-methyladenine modification","volume":"22","author":"Du","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"key":"2024012514013344700_ref54","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.928508","article-title":"First trimester plasma MicroRNA levels predict risk of developing gestational diabetes mellitus","volume":"13","author":"L\u00e9gar\u00e9","year":"2022","journal-title":"Front Endocrinol"},{"key":"2024012514013344700_ref55","doi-asserted-by":"crossref","first-page":"e002703","DOI":"10.1136\/bmjdrc-2021-002703","article-title":"First trimester plasma microRNAs levels predict Matsuda index-estimated insulin sensitivity between 24th and 29th week of pregnancy","volume":"10","author":"L\u00e9gar\u00e9","year":"2022","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2024012514013344700_ref56","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.839344","article-title":"miRNAs as predictive factors in early diagnosis of gestational diabetes mellitus","volume":"13","author":"Juchnicka","year":"2022","journal-title":"Front Endocrinol"},{"key":"2024012514013344700_ref57","doi-asserted-by":"crossref","first-page":"20295","DOI":"10.1038\/s41598-022-23816-3","article-title":"Analysis of serum circulating microRNAs level in Malaysian patients with gestational diabetes mellitus","volume":"12","author":"Jamalpour","year":"2022","journal-title":"Sci Rep"},{"key":"2024012514013344700_ref58","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/jdi.13493","article-title":"Diagnostic value of dysregulated microribonucleic acids in the placenta and circulating exosomes in gestational diabetes mellitus","volume":"12","author":"Zhang","year":"2021","journal-title":"J Diabetes Investig"},{"key":"2024012514013344700_ref59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/cells10010170","article-title":"The predictive value of miR-16, -29a and -134 for early identification of gestational diabetes: a nested analysis of the DALI cohort","volume":"10","author":"S\u00f8rensen","year":"2021","journal-title":"Cell"},{"key":"2024012514013344700_ref60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084276","article-title":"Identification and validation of miR-222-3p and miR-409-3p as plasma biomarkers in gestational diabetes mellitus sharing validated target genes involved in metabolic homeostasis","volume":"23","author":"Filardi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2024012514013344700_ref61","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s40291-022-00591-5","article-title":"Gestational diabetes is associated with an increased expression of miR-27a in peripheral blood mononuclear cells","volume":"26","author":"Radoji\u010di\u0107","year":"2022","journal-title":"Mol Diagn Ther"},{"key":"2024012514013344700_ref62","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/09513590.2021.1908990","article-title":"Circulating miRNAs miR-574-5p and miR-3135b are potential metabolic regulators for serum lipids and blood glucose in gestational diabetes mellitus","volume":"37","author":"Wang","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"2024012514013344700_ref63","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ejogrb.2022.03.005","article-title":"Study of serum miR-518 and its correlation with inflammatory factors in patients with gestational diabetes mellitus complicated with hypertensive disorder complicating pregnancy","volume":"272","author":"Li","year":"2022","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2024012514013344700_ref64","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1111\/jcmm.17941","article-title":"Placenta-derived exosomal miR-135a-5p promotes gestational diabetes mellitus pathogenesis by activating PI3K\/AKT signalling pathway via SIRT1","volume":"27","author":"Zhang","year":"2023","journal-title":"J Cell Mol Med"},{"key":"2024012514013344700_ref65","doi-asserted-by":"crossref","first-page":"100605","DOI":"10.1016\/j.repbio.2022.100605","article-title":"MicroRNA-195-5p facilitates endothelial dysfunction by inhibiting vascular endothelial growth factor a in gestational diabetes mellitus","volume":"22","author":"Zheng","year":"2022","journal-title":"Reprod Biol"},{"key":"2024012514013344700_ref66","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1080\/21655979.2021.1933678","article-title":"MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase","volume":"12","author":"Zhang","year":"2021","journal-title":"Bioengineered"},{"key":"2024012514013344700_ref67","doi-asserted-by":"crossref","first-page":"107959","DOI":"10.1016\/j.jdiacomp.2021.107959","article-title":"Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A","volume":"35","author":"Zhang","year":"2021","journal-title":"J Diabetes Complications"},{"key":"2024012514013344700_ref68","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.2147\/DMSO.S385774","article-title":"miR-17-5p promotes glucose uptake of HTR8\/SVneo trophoblast cells by inhibiting TXNIP\/NLRP3 Inflammasome pathway","volume":"15","author":"Jiang","year":"2022","journal-title":"Diabetes Metab Syndr Obes Targets Ther"},{"issue":"7","key":"2024012514013344700_ref69","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24557","article-title":"The downregulation of miR-22 and miR-372 may contribute to gestational diabetes mellitus through regulating glucose metabolism via the PI3K\/AKT\/GLUT4 pathway","volume":"36","author":"Li","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"2024012514013344700_ref70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3892\/etm.2022.11780","article-title":"MicroRNA-143-3p levels are reduced in the peripheral blood of patients with gestational diabetes mellitus and influences pancreatic \u03b2-cell function and viability","volume":"25","author":"Liu","year":"2022","journal-title":"Exp Ther Med"},{"key":"2024012514013344700_ref71","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/21655979.2021.2001219","article-title":"miR-134-5p promotes inflammation and apoptosis of trophoblast cells via regulating FOXP2 transcription in gestational diabetes mellitus","volume":"13","author":"Ke","year":"2021","journal-title":"Bioengineered"},{"key":"2024012514013344700_ref72","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1515\/med-2021-0247","article-title":"miR-377 inhibition enhances the survival of trophoblast cells via upregulation of FNDC5 in gestational diabetes mellitus","volume":"16","author":"Hua","year":"2021","journal-title":"Open Med"},{"key":"2024012514013344700_ref73","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3892\/etm.2021.9661","article-title":"MicroRNA-1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose-induced inhibition of trophoblast cell viability by suppressing TP53INP1","volume":"21","author":"Liu","year":"2021","journal-title":"Exp Ther Med"},{"key":"2024012514013344700_ref74","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s10528-021-10064-9","article-title":"MiR-34b-3p impaired HUVECs viability and migration via targeting PDK1 in an in vitro model of gestational diabetes mellitus","volume":"59","author":"Song","year":"2021","journal-title":"Biochem Genet"},{"key":"2024012514013344700_ref75","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00592-022-01910-2","article-title":"Human placenta mesenchymal stem cell-derived exosome shuttling microRNA-130b-3p from gestational diabetes mellitus patients targets ICAM-1 and perturbs human umbilical vein endothelial cell angiogenesis","volume":"59","author":"Gao","year":"2022","journal-title":"Acta Diabetol"},{"key":"2024012514013344700_ref76","first-page":"1","article-title":"MiR-6869-5p induces M2 polarization by regulating PTPRO in gestational diabetes mellitus","volume":"2021","author":"Wang","year":"2021","journal-title":"Mediators Inflamm"},{"key":"2024012514013344700_ref77","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.2337\/db21-0909","article-title":"Plasma exosomal miRNAs associated with metabolism as early predictor of gestational diabetes mellitus","volume":"71","author":"Ye","year":"2022","journal-title":"Diabetes"},{"key":"2024012514013344700_ref78","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.917386","article-title":"miR-199a is upregulated in GDM targeting the MeCP2-Trpc3 pathway","volume":"13","author":"Guan","year":"2022","journal-title":"Front Endocrinol"},{"key":"2024012514013344700_ref79","article-title":"Association of miR-196a2 and miR-27a polymorphisms with gestational diabetes mellitus susceptibility in a Chinese population","volume":"14","author":"Zeng","year":"2023","journal-title":"Front Endocrinol"},{"key":"2024012514013344700_ref80","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4274\/balkanmedj.galenos.2021.2021-8-140","article-title":"Inhibiting miR-182-3p alleviates gestational diabetes mellitus by improving insulin resistance in skeletal muscle","volume":"39","author":"Rao","year":"2021","journal-title":"Balkan Med J"},{"key":"2024012514013344700_ref81","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.amjms.2020.06.032","article-title":"Effects of miR-152-mediated targeting of SOCS3 on hepatic insulin resistance in gestational diabetes mellitus mice","volume":"361","author":"Li","year":"2021","journal-title":"Am J Med Sci"},{"key":"2024012514013344700_ref82","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1615\/JEnvironPatholToxicolOncol.2022041670","article-title":"miR-210-3p impairs pancreatic \u03b2-cell function by targeting Dtx1 in gestational diabetes mellitus","volume":"41","author":"Cao","year":"2022","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"2024012514013344700_ref83","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.11942","article-title":"miR-875-5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats","volume":"23","author":"Fu","year":"2021","journal-title":"Mol Med Rep"},{"key":"2024012514013344700_ref84","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-021-03195-5","article-title":"Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM","volume":"20","author":"Jiang","year":"2022","journal-title":"J Transl Med"},{"key":"2024012514013344700_ref85","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.2147\/DMSO.S316043","article-title":"Overexpression of circACTR2 in gestational diabetes mellitus predicts intrauterine death, fetal malformation, and intrauterine infection","volume":"14","author":"Zhu","year":"2021","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2024012514013344700_ref86","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.2147\/DMSO.S334728","article-title":"CircRNA circVEGFC is highly expressed in gestational diabetes mellitus (GDM) and it is correlated with multiple adverse events","volume":"14","author":"She","year":"2021","journal-title":"Diabetes Metab Syndr Obes Targets Ther"},{"key":"2024012514013344700_ref87","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1080\/21655979.2021.1967077","article-title":"Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200\/MEOX2 axis","volume":"12","author":"Huang","year":"2021","journal-title":"Bioengineered"},{"key":"2024012514013344700_ref88","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/09513590.2021.1991911","article-title":"Hsa_circRNA_102682 is closely related to lipid metabolism in gestational diabetes mellitus","volume":"38","author":"Wu","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"2024012514013344700_ref89","doi-asserted-by":"crossref","first-page":"e24826","DOI":"10.1002\/jcla.24826","article-title":"The role of 25(OH)D3 and circRNAs in early diagnosis of gestational diabetes mellitus","volume":"37","author":"Zou","year":"2023","journal-title":"J Clin Lab Anal"},{"key":"2024012514013344700_ref90","article-title":"Downregulation of circ_0001578 promotes gestational diabetes mellitus by inducing placental inflammation via the NF-\u03baB and JNKs pathways","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Endocrinol"},{"key":"2024012514013344700_ref91","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1507\/endocrj.EJ21-0528","article-title":"Circ_FOXP1 promotes the growth and survival of high glucose-treated human trophoblast cells through the regulation of miR-508-3p\/SMAD family member 2 pathway","volume":"69","author":"Li","year":"2022","journal-title":"Endocr J"},{"key":"2024012514013344700_ref92","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/mrd.23667","article-title":"Circular RNA SESN2 aggravates gestational trophoblast cell damage induced by high glucose by binding to IGF2BP2","volume":"90","author":"Huang","year":"2023","journal-title":"Mol Reprod Dev"},{"issue":"1","key":"2024012514013344700_ref93","first-page":"121","article-title":"The possible involvement of circRNA DMNT1\/p53\/JAK\/STAT in gestational diabetes mellitus and preeclampsia, cell death","volume":"8","author":"Bao","year":"2022","journal-title":"Discovery"},{"key":"2024012514013344700_ref94","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12967-022-03386-8","article-title":"circMAP3K4 regulates insulin resistance in trophoblast cells during gestational diabetes mellitus by modulating the miR-6795-5p\/PTPN1 axis","volume":"20","author":"Du","year":"2022","journal-title":"J Transl Med"},{"key":"2024012514013344700_ref95","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3526","article-title":"Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation","volume":"25","author":"Jiang","year":"2023","journal-title":"J Gene Med"},{"key":"2024012514013344700_ref96","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13098-021-00678-9","article-title":"Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p\/PAK1 axis","volume":"13","author":"Zhang","year":"2021","journal-title":"Diabetol Metab Syndr"},{"key":"2024012514013344700_ref97","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.774608","article-title":"Upregulation of T cell receptor signaling pathway components in gestational diabetes mellitus patients: joint analysis of mRNA and circRNA expression profiles","volume":"12","author":"Chen","year":"2022","journal-title":"Front Endocrinol"},{"key":"2024012514013344700_ref98","first-page":"1","article-title":"Exosomal circular RNA hsa_circ_0046060 of umbilical cord mesenchymal stromal cell ameliorates glucose metabolism and insulin resistance in gestational diabetes mellitus via the miR-338-3p\/G6PC2 Axis","volume":"2022","author":"Cao","year":"2022","journal-title":"Int J Endocrinol"},{"key":"2024012514013344700_ref99","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1530\/EJE-19-0206","article-title":"Early diagnosis of gestational diabetes mellitus using circulating microRNAs","volume":"181","author":"Yoffe","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"2024012514013344700_ref100","doi-asserted-by":"crossref","first-page":"11691","DOI":"10.1080\/07391102.2021.1962738","article-title":"iGluK-deep: computational identification of lysine glutarylation sites using deep neural networks with general pseudo amino acid compositions","volume":"40","author":"Naseer","year":"2021","journal-title":"J Biomol Struct Dyn"},{"key":"2024012514013344700_ref101","doi-asserted-by":"crossref","first-page":"107874","DOI":"10.1016\/j.compbiolchem.2023.107874","article-title":"DeepBCE: evaluation of deep learning models for identification of immunogenic B-cell epitopes","volume":"104","author":"Attique","year":"2023","journal-title":"Comput Biol Chem"},{"key":"2024012514013344700_ref102","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12859-022-04715-w","article-title":"MAGCNSE: predicting lncRNA-disease associations using multi-view attention graph convolutional network and stacking ensemble model","volume":"23","author":"Liang","year":"2022","journal-title":"BMC Bioinformatics"},{"key":"2024012514013344700_ref103","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.csbj.2023.03.027","article-title":"ncRPI-LGAT: prediction of ncRNA-protein interactions with line graph attention network framework","volume":"21","author":"Han","year":"2023","journal-title":"Comput Struct Biotechnol J"},{"key":"2024012514013344700_ref104","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.3390\/cells11213457","article-title":"Chemerin-induced down-regulation of placenta-derived exosomal miR-140-3p and miR-574-3p promotes umbilical vein endothelial cells proliferation, migration, and tube formation in gestational diabetes mellitus","volume":"11","author":"Zhang","year":"2022","journal-title":"Cell"},{"key":"2024012514013344700_ref105","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s12967-021-02999-9","article-title":"Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus","volume":"19","author":"Nair","year":"2021","journal-title":"J Transl Med"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/1\/bbad489\/56256034\/bbad489.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/1\/bbad489\/56256034\/bbad489.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T17:01:51Z","timestamp":1706202111000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbad489\/7512646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,11,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbad489","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"type":"print","value":"1467-5463"},{"type":"electronic","value":"1477-4054"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,11,22]]},"article-number":"bbad489"}}