{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:03:19Z","timestamp":1780934599643,"version":"3.54.1"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["120C120"],"award-info":[{"award-number":["120C120"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Complex biological processes in cells are embedded in the interactome, representing the complete set of protein\u2013protein interactions. Mapping and analyzing the protein structures are essential to fully comprehending these processes\u2019 molecular details. Therefore, knowing the structural coverage of the interactome is important to show the current limitations. Structural modeling of protein\u2013protein interactions requires accurate protein structures. In this study, we mapped all experimental structures to the reference human proteome. Later, we found the enrichment in structural coverage when complementary methods such as homology modeling and deep learning (AlphaFold) were included. We then collected the interactions from the literature and databases to form the reference human interactome, resulting in 117\u00a0897 non-redundant interactions. When we analyzed the structural coverage of the interactome, we found that the number of experimentally determined protein complex structures is scarce, corresponding to 3.95% of all binary interactions. We also analyzed known and modeled structures to potentially construct the structural interactome with a docking method. Our analysis showed that 12.97% of the interactions from HuRI and 73.62% and 32.94% from the filtered versions of STRING and HIPPIE could potentially be modeled with high structural coverage or accuracy, respectively. Overall, this paper provides an overview of the current state of structural coverage of the human proteome and interactome.<\/jats:p>","DOI":"10.1093\/bib\/bbad496","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T10:34:23Z","timestamp":1703068463000},"source":"Crossref","is-referenced-by-count":13,"title":["Structural coverage of the human interactome"],"prefix":"10.1093","volume":"25","author":[{"given":"Kayra","family":"Kosoglu","sequence":"first","affiliation":[{"name":"Computational Sciences and Engineering, College of Engineering, Koc University , 34450 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Aydin","sequence":"additional","affiliation":[{"name":"Computational Sciences and Engineering, College of Engineering, Koc University , 34450 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Tuncbag","sequence":"additional","affiliation":[{"name":"School of Medicine, Koc University , 34450 Istanbul , Turkey"},{"name":"Department of Chemical and Biological Engineering, College of Engineering, Koc University , 34450 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, College of Engineering, Koc University , 34450 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-4049","authenticated-orcid":false,"given":"Ozlem","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, College of Engineering, Koc University , 34450 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"issue":"3","key":"2024010515575651700_ref1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.0030042","article-title":"Deciphering protein-protein interactions. 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