{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:19:12Z","timestamp":1784132352796,"version":"3.55.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370711"],"award-info":[{"award-number":["32370711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Medical Research Funds","award":["A2303033"],"award-info":[{"award-number":["A2303033"]}]},{"name":"Shenzhen Science and Technology Program","award":["RKX20220705152810024"],"award-info":[{"award-number":["RKX20220705152810024"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220530152409020"],"award-info":[{"award-number":["JCYJ20220530152409020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>N6-methyladenosine (m6A) RNA methylation is the predominant epigenetic modification for mRNAs that regulates various cancer-related pathways. However, the prognostic significance of m6A modification regulators remains unclear in glioma. By integrating the TCGA lower-grade glioma (LGG) and glioblastoma multiforme (GBM) gene expression data, we demonstrated that both the m6A regulators and m6A-target genes were associated with glioma prognosis and activated various cancer-related pathways. Then, we paired m6A regulators and their target genes as m6A-related gene pairs (MGPs) using the iPAGE algorithm, among which 122 MGPs were significantly reversed in expression between LGG and GBM. Subsequently, we employed LASSO Cox regression analysis to construct an MGP signature (MrGPS) to evaluate glioma prognosis. MrGPS was independently validated in CGGA and GEO glioma cohorts with high accuracy in predicting overall survival. The average area under the receiver operating characteristic curve (AUC) at 1-, 3- and 5-year intervals were 0.752, 0.853 and 0.831, respectively. Combining clinical factors of age and radiotherapy, the AUC of MrGPS was much improved to around 0.90. Furthermore, CIBERSORT and TIDE algorithms revealed that MrGPS is indicative for the immune infiltration level and the response to immune checkpoint inhibitor therapy in glioma patients. In conclusion, our study demonstrated that m6A methylation is a prognostic factor for glioma and the developed prognostic model MrGPS holds potential as a valuable tool for enhancing patient management and facilitating accurate prognosis assessment in cases of glioma.<\/jats:p>","DOI":"10.1093\/bib\/bbad498","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T01:10:53Z","timestamp":1704330653000},"source":"Crossref","is-referenced-by-count":19,"title":["MrGPS: an m6A-related gene pair signature to predict the prognosis and immunological impact of glioma patients"],"prefix":"10.1093","volume":"25","author":[{"given":"Ning","family":"Zhang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People\u2019s Hospital , Shenzhen , China"},{"name":"The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University"},{"name":"Neuroscience Center, Shantou University Medical College , Shantou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxia","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People\u2019s Hospital , Shenzhen , China"},{"name":"The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University"},{"name":"Neuroscience Center, Shantou University Medical College , Shantou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People\u2019s Hospital , Shenzhen , China"},{"name":"The First Affiliated Hospital of 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University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"International Digital Economy Academy , Shenzhen , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshan","family":"Geng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People\u2019s Hospital , Shenzhen , China"},{"name":"The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Shantou University Medical College , Shantou , 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