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With the development of artificial intelligence (AI) technology, it is key for NP to develop network-based AI methods to reveal the treatment mechanism of complex diseases from massive omics data. In this review, focusing on the TCM-NP, we summarize involved AI methods into three categories: network relationship mining, network target positioning and network target navigating, and present the typical application of TCM-NP in uncovering biological basis and clinical value of Cold\/Hot syndromes. Collectively, our review provides researchers with an innovative overview of the methodological progress of NP and its application in TCM from the AI perspective.<\/jats:p>","DOI":"10.1093\/bib\/bbad518","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:03:53Z","timestamp":1704877433000},"source":"Crossref","is-referenced-by-count":546,"title":["Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-207X","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute for TCM-X , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"},{"name":"Tsinghua University , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0469-1263","authenticated-orcid":false,"given":"Dingfan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for TCM-X , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"},{"name":"Tsinghua University , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-3751","authenticated-orcid":false,"given":"Wuai","family":"Zhou","sequence":"additional","affiliation":[{"name":"China Mobile Information System Integration Co., Ltd , Beijing 100032 , China"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for TCM-X , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"},{"name":"Tsinghua University , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"}]},{"given":"Boyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for TCM-X , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"},{"name":"Tsinghua University , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"}]},{"given":"Tingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for TCM-X , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"},{"name":"Tsinghua University , MOE Key Laboratory of Bioinformatics\/Bioinformatics Division, BNRIST, Department of Automation, , Beijing 100084 , China"}]},{"given":"Shao","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for TCM-X , MOE Key Laboratory of 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