{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:14:09Z","timestamp":1774682049901,"version":"3.50.1"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["11904189"],"award-info":[{"award-number":["11904189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["52007087"],"award-info":[{"award-number":["52007087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2023J078"],"award-info":[{"award-number":["2023J078"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ningbo Top Medical and Health Research Program","award":["2022020304"],"award-info":[{"award-number":["2022020304"]}]},{"DOI":"10.13039\/100022955","name":"Fundamental Research Funds for the Provincial Universities of Zhejiang","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022955","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PhD Research Initiation Project of Lihuili Hospital","award":["2023BSKY-HFJ"],"award-info":[{"award-number":["2023BSKY-HFJ"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM145409"],"award-info":[{"award-number":["R35GM145409"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM121342"],"award-info":[{"award-number":["P20GM121342"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South Carolina Alzheimer\u2019s Disease Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The aggregation of medin forming aortic medial amyloid is linked to arterial wall degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are correlated with an increased presence of vascular amyloid-\u03b2 (A\u03b2) aggregates, a hallmark of Alzheimer\u2019s disease (AD) and vascular dementia. The cross-interaction between medin and A\u03b2 results in the formation of heterologous fibrils through co-aggregation and cross-seeding processes both in vitro and in vivo. However, a comprehensive molecular understanding of the cross-interaction between medin and A\u03b2\u2014two intrinsically disordered proteins\u2014is critically lacking. Here, we employed atomistic discrete molecular dynamics simulations to systematically investigate the self-association, co-aggregation and also the phenomenon of cross-seeding between these two proteins. Our results demonstrated that both A\u03b2 and medin were aggregation prone and their mixture tended to form \u03b2-sheet-rich hetero-aggregates. The formation of A\u03b2-medin hetero-aggregates did not hinder A\u03b2 and medin from recruiting additional A\u03b2 and medin peptides to grow into larger \u03b2-sheet-rich aggregates. The \u03b2-barrel oligomer intermediates observed in the self-aggregations of A\u03b2 and medin were also present during their co-aggregation. In cross-seeding simulations, preformed A\u03b2 fibrils could recruit isolated medin monomers to form elongated \u03b2-sheets. Overall, our comprehensive simulations suggested that the cross-interaction between A\u03b2 and medin may contribute to their pathological aggregation, given the inherent amyloidogenic tendencies of both medin and A\u03b2. Targeting medin, therefore, could offer a novel therapeutic approach to preserving brain function during aging and AD by improving vascular health.<\/jats:p>","DOI":"10.1093\/bib\/bbad526","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T18:12:07Z","timestamp":1706206327000},"source":"Crossref","is-referenced-by-count":15,"title":["Computational insights into the cross-talk between medin and A<i>\u03b2<\/i>: implications for age-related vascular risk factors in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"25","author":[{"given":"Fengjuan","family":"Huang","sequence":"first","affiliation":[{"name":"Ningbo Institute of Innovation for Combined Medicine and Engineering, Lihuili Hospital Affiliated to Ningbo University, Ningbo University , Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjie","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University , Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University , Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Sport and Exercise Science, Zhejiang University , Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangfang","family":"Lian","sequence":"additional","affiliation":[{"name":"Ningbo Institute of Innovation for Combined Medicine and Engineering, Lihuili Hospital Affiliated to Ningbo University, Ningbo University , Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Ningbo University , Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-6336","authenticated-orcid":false,"given":"Feng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, Clemson University , Clemson, SC 29634, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-7131","authenticated-orcid":false,"given":"Yunxiang","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University , Ningbo 315211, China"},{"name":"Department of Physics and Astronomy, Clemson University , Clemson, SC 29634, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"2024012518112787100_ref1","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1021\/acs.chemrev.0c01122","article-title":"Amyloid 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