{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:03:47Z","timestamp":1761563027650,"version":"3.41.2"},"reference-count":130,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A2C1005830"],"award-info":[{"award-number":["NRF-2022R1A2C1005830"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Veterinary systems biology is an innovative approach that integrates biological data at the molecular and cellular levels, allowing for a more extensive understanding of the interactions and functions of complex biological systems in livestock and veterinary science. It has tremendous potential to integrate multi-omics data with the support of vetinformatics resources for bridging the phenotype\u2013genotype gap via computational modeling. To understand the dynamic behaviors of complex systems, computational models are frequently used. It facilitates a comprehensive understanding of how a host system defends itself against a pathogen attack or operates when the pathogen compromises the host\u2019s immune system. In this context, various approaches, such as systems immunology, network pharmacology, vaccinology and immunoinformatics, can be employed to effectively investigate vaccines and drugs. By utilizing this approach, we can ensure the health of livestock. This is beneficial not only for animal welfare but also for human health and environmental well-being. Therefore, the current review offers a detailed summary of systems biology advancements utilized in veterinary sciences, demonstrating the potential of the holistic approach in disease epidemiology, animal welfare and productivity.<\/jats:p>","DOI":"10.1093\/bib\/bbae025","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T07:00:00Z","timestamp":1707721200000},"source":"Crossref","is-referenced-by-count":5,"title":["Veterinary systems biology for bridging the phenotype\u2013genotype gap via computational modeling for disease epidemiology and animal welfare"],"prefix":"10.1093","volume":"25","author":[{"given":"Rajesh Kumar","family":"Pathak","sequence":"first","affiliation":[{"name":"Department of Animal Science and Technology, Chung-Ang University , Anseong-si, Gyeonggi-do 17546, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-398X","authenticated-orcid":false,"given":"Jun-Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology, Chung-Ang University , Anseong-si, Gyeonggi-do 17546, Republic of Korea"}]}],"member":"286","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"2024021206595057400_ref1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/2224-3151.282996","article-title":"Animal welfare, one health and emergency preparedness and response in the Asia-Pacific region","volume":"9","author":"Gongal","year":"2020","journal-title":"WHO South East Asia J Public Health"},{"key":"2024021206595057400_ref2","doi-asserted-by":"crossref","first-page":"1008728","DOI":"10.3389\/fvets.2022.1008728","article-title":"Vetinformatics from functional genomics to drug discovery: insights into decoding complex molecular mechanisms of livestock systems in veterinary 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