{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:47:09Z","timestamp":1779187629088,"version":"3.51.4"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical Science Data Center of Fudan University"},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1101100"],"award-info":[{"award-number":["2022YFF1101100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000470"],"award-info":[{"award-number":["32000470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370697"],"award-info":[{"award-number":["32370697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Phages can specifically recognize and kill bacteria, which lead to important application value of bacteriophage in bacterial identification and typing, livestock aquaculture and treatment of human bacterial infection. Considering the variety of human-infected bacteria and the continuous discovery of numerous pathogenic bacteria, screening suitable therapeutic phages that are capable of infecting pathogens from massive phage databases has been a principal step in phage therapy design. Experimental methods to identify phage\u2013host interaction (PHI) are time-consuming and expensive; high-throughput computational method to predict PHI is therefore a potential substitute. Here, we systemically review bioinformatic methods for predicting PHI, introduce reference databases and in silico models applied in these methods and highlight the strengths and challenges of current tools. Finally, we discuss the application scope and future research direction of computational prediction methods, which contribute to the performance improvement of prediction models and the development of personalized phage therapy.<\/jats:p>","DOI":"10.1093\/bib\/bbae117","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T02:33:55Z","timestamp":1711852435000},"source":"Crossref","is-referenced-by-count":27,"title":["Advances in phage\u2013host interaction prediction: <i>in silico<\/i> method enhances the development of phage therapies"],"prefix":"10.1093","volume":"25","author":[{"given":"Wanchun","family":"Nie","sequence":"first","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology , Shanghai, 200093 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-3923","authenticated-orcid":false,"given":"Tianyi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Science , Zhongshan Hospital; Intelligent Medicine Institute, , Shanghai, 200032 , China"},{"name":"Fudan University , Zhongshan Hospital; Intelligent Medicine Institute, , Shanghai, 200032 , China"},{"name":"Shanghai Institute of Infectious Disease and Biosecurity, Fudan University , Shanghai, 200032 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology , Shanghai, 200093 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Clinical Science , Zhongshan Hospital; Intelligent Medicine Institute, , Shanghai, 200032 , China"},{"name":"Fudan University , Zhongshan Hospital; Intelligent Medicine Institute, , Shanghai, 200032 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology , Shanghai, 200093 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology , Shanghai, 200093 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"issue":"4814","key":"2024033102334725400_ref1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0140-6736(01)20383-3","article-title":"An investigation on the nature 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