{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:29:25Z","timestamp":1774992565438,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Municipal Key Clinical Specialty, Shanghai Key Laboratory of Emergency Prevention","award":["shslczdzk02202"],"award-info":[{"award-number":["shslczdzk02202"]}]},{"name":"Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases","award":["20dz2261100"],"award-info":[{"award-number":["20dz2261100"]}]},{"name":"Innovative Research Team of High-level Local Universities in Shanghai and Shanghai Targeted Biomedical Emergency Project","award":["23DX1900300"],"award-info":[{"award-number":["23DX1900300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Coronavirus disease 2019 (COVID-19) has been wreaking havoc for 3 years. PANoptosis, a distinct and physiologically relevant inflammatory programmed cell death, perpetuates cytokine storm and multi-organ injuries in COVID-19. Although PANoptosis performs indispensable roles in host defense, further investigation is needed to elucidate the exact processes through which PANoptosis modulates immunological responses and prognosis in COVID-19. This study conducted a bioinformatics analysis of online single-cell RNA sequence (scRNA-seq) and bulk RNA-seq datasets to explore the potential of PANoptosis as an indicator of COVID-19 severity. The degree of PANoptosis in bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) indicated the severity of COVID-19. Single-cell transcriptomics identified pro-inflammatory monocytes as one of the primary sites of PANoptosis in COVID-19. The study subsequently demonstrated the immune and metabolic characteristics of this group of pro-inflammatory monocytes. In addition, the analysis illustrated that dexamethasone was likely to alleviate inflammation in COVID-19 by mitigating PANoptosis. Finally, the study showed that the PANoptosis-related genes could predict the intensive care unit admission (ICU) and outcomes of COVID-19 patients who are hospitalized.<\/jats:p>","DOI":"10.1093\/bib\/bbae124","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T03:28:26Z","timestamp":1711855706000},"source":"Crossref","is-referenced-by-count":16,"title":["PANoptosis, an indicator of COVID-19 severity and outcomes"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1062-3303","authenticated-orcid":false,"given":"Qingyuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Shanghai Jiao Tong University School of Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases , Shanghai 200025 , China"}]},{"given":"Wanmei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Shanghai Jiao Tong University School of Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases , Shanghai 200025 , China"}]},{"given":"Hanizaier","family":"Reheman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Shanghai Jiao Tong University School of Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases , Shanghai 200025 , China"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology , State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Shanghai Jiao Tong University School of Medicine , State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, , Shanghai 200025 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-544X","authenticated-orcid":false,"given":"Jieming","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Shanghai Jiao Tong University School of Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases , Shanghai 200025 , China"}]},{"given":"Yanan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Shanghai Jiao Tong University School of Medicine , Ruijin Hospital, , Shanghai 200025 , China"},{"name":"Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases , Shanghai 200025 , China"}]}],"member":"286","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"2024033103281029600_ref1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.immuni.2020.05.002","article-title":"Immunology of COVID-19: current state of the science","volume":"52","author":"Vabret","year":"2020","journal-title":"Immunity"},{"key":"2024033103281029600_ref2","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.abm8108","article-title":"The immunology and immunopathology of COVID-19","volume":"375","author":"Merad","year":"2022","journal-title":"Science"},{"key":"2024033103281029600_ref3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.immuni.2020.05.004","article-title":"Respiratory virus infections: understanding 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