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However, a comprehensive database that consolidates both synthetically derived and naturally occurring cyclic peptides is conspicuously absent. To address this void, we introduce CyclicPepedia (https:\/\/www.biosino.org\/iMAC\/cyclicpepedia\/), a pioneering database that encompasses 8744 known cyclic peptides. This repository, structured as a composite knowledge network, offers a wealth of information encompassing various aspects of cyclic peptides, such as cyclic peptides\u2019 sources, categorizations, structural characteristics, pharmacokinetic profiles, physicochemical properties, patented drug applications, and a collection of crucial publications. Supported by a user-friendly knowledge retrieval system and calculation tools specifically designed for cyclic peptides, CyclicPepedia will be able to facilitate advancements in cyclic peptide drug development.<\/jats:p>","DOI":"10.1093\/bib\/bbae190","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T09:06:47Z","timestamp":1714295207000},"source":"Crossref","is-referenced-by-count":32,"title":["CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides"],"prefix":"10.1093","volume":"25","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University , Shanghai 200072, P. R. 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